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並前往http://holford.fmhs.auckland.ac.nz/research/nlmixr/warfarin/warf_simtr2_PKPD_vpc_ui_saem_foce_B-18-v3_PDF.html

Warfarin PKPD - Professor Nick Holford

The VPC and GOF plots shows the immediate effect model describes the data poorly. ... CEF <- nlmixr(pd.ce.emax, data.pd, est="focei", control=list(print=0 ...

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