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#1EIF4F - 維基百科，自由的百科全書
eIF4F （eukaryotic translation initiation factor 4F，真核起始因子4F）是一種在真核翻譯起始中發揮重要功能的複合物。 eIF4F由eIF4A、eIF4E、eIF4G三個起始因子組成 ...
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#2Initiation Factor 4F - an overview | ScienceDirect Topics
In eukaryotes, mature mRNAs are exported from the nucleus to the cytosol after splicing. The cap-binding eukaryotic initiation factor 4F (eIF4F), a complex that ...
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#3eIF4 initiation factors: effectors of mRNA recruitment ... - PubMed
由 AC Gingras 著作 · 1999 · 被引用 2554 次 — Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA. This event is the rate-limiting ...
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#4Molecular Pathways: The eIF4F Translation Initiation Complex ...
由 H Malka-Mahieu 著作 · 2017 · 被引用 60 次 — Abstract. The eIF4F complex regulates the cap-dependent mRNA translation process. · Background. Among the different steps in gene expression, ...
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#5eIF4E3 forms an active eIF4F complex ... - Oxford Academic
eIF4G is a member of the eIF4F trimolecular complex that assembles on the 5′ cap and carries the eIF4E cap-binding protein and the eIF4A DEAD-box helicase (5).
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#6Regulation of the Translation Initiation Factor eIF4F by ...
eIF4F is a complex of cellular polypeptides (2) whose core is composed of a cap binding protein (eIF4E), a large scaffolding subunit (eIF4G), ...
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#8eIF4F: A Retrospective* - Journal of Biological Chemistry
A hypothesis that requires the disassembly of eIF4F during translation initiation to yield free subunits (eIF4A,. eIF4E, and eIF4G) is presented.
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#9Targeting eIF4F translation initiation complex with SBI-756 ...
Upon release, eIF4E binds the scaffolding protein eIF4G1 and the RNA helicase, eIF4A, to form the eIF4F protein translation initiation ...
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#10Toward the mechanism of eIF4F-mediated ribosomal ...
eIF4F comprises the cap-binding protein eIF4E, the DEAD-box RNA helicase eIF4A (which also exists in a free form), and the eIF4G scaffold, which interacts with ...
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#11eIF4E3 Forms an Active eIF4F Complex during ... - bioRxiv
The formation of the eIF4F complex can be disrupted by the 4E binding proteins (4EBPs) that compete with eIF4G for eIF4E because of their common ...
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#12Inhibition of eIF4F complex loading inhibits the survival of ...
eIF4E can be combined with the scaffolding protein eIF4G and the ATP-dependent RNA helicase eIF4A to form the eIF4F complex (7), ...
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#13Reversing chemoresistance by small molecule inhibition of ...
eIF4F is composed of: eIF4E, the cap-binding protein; eIF4A, a DEAD-box RNA helicase; and eIF4G, a scaffolding protein that bridges the ...
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#14Monitoring flux in signalling pathways through measurements ...
The eIF4F complex is frequently dysregulated in human tumours due to activating mutations in critical genes in the PI3K/AKT and RAS/ERK ...
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#15EIF4E Gene - GeneCards | IF4E Protein | IF4E Antibody
Aliases for EIF4E Gene · GeneCards Symbol: EIF4E · Eukaryotic Translation Initiation Factor 4E · EIF4EL1 · EIF4E1 · EIF4F · MRNA Cap-Binding Protein.
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#16Targeting the eIF4F Translation Initiation ... - ResearchGate
... A central component in this molecular organization is the heterotrimeric "eIF4F" complex formed between eIF4G, the mRNA cap-binding protein eIF4E and the ...
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#17Targeting EIF4F complex in non-small cell lung cancer cells
The translation initiation EIF4F complex has been shown to play important roles in cancer progression, but its functional role and ...
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#18Translation initiation complex eIF4F is a therapeutic target for ...
Treatment with the active -site dual mTOR inhibitor CC214-1 reduced the level of the eIF4F complex by decreasing the cap bound fraction of eIF4G and increasing ...
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#19Translation - Regulation of EIF4F activity Pathway Map
eIF4F complex consists of Eukaryotic translation initiation factor 4 gamma, factor 4E and factor 4A (eIF4G, eIF4E, eIF4A). eIF4G serves as a scaffold ...
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#20Multiple components of eIF4F are required for protein ...
In addition to mRNA cap binding via eIF4E, the eIF4F complex also contains eIF4A, an RNA helicase critical for cap-dependent translation (Raught ...
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#21The eIF4F and eIFiso4F Complexes of Plants: An Evolutionary ...
Translation initiation in eukaryotes requires a number of initiation factors to recruit the assembled ribosome to mRNA. The eIF4F complex plays a key role ...
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#22Identification of a Highly Deregulated eIF4F Translation ...
Identification of a Highly Deregulated eIF4F Translation Initiation Complex in Drug-Resistant BCR-ABL + Cells By a Phospho-Proteomic Antibody ...
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#23The Translation Repressor 4E-BP2 Is Critical for eIF4F ...
Replacement of 4E-BP with eIF4G leads to formation of the eIF4F complex and promotes translation initiation. eIF4F complex-associated eIF4E is ...
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#24EIF4E - Eukaryotic translation initiation factor 4E - UniProt
Post-translational modification i. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.7 Publications.
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#25The mTORC1‐eIF4F axis controls paused pluripotency
由 X Xu 著作 — Abstract Mouse embryonic stem cells (mESCs) can self-renew indefinitely and maintain pluripotency. Inhibition of mechanistic target of ...
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#26Plant Cap-binding Complexes Eukaryotic Initiation Factors ...
eIF4F is comprised of the subunits eIF4G and eIF4E and often the helicase, eIF4A. The eIF4G subunit serves as an assembly point for other initiation factors, ...
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#27The Regulation of eIF4F During Cell Growth and Cell Death
Initiation Factor Translation Initiation Factor Eukaryotic Initiation Factor Internal Ribosome Entry Site Activity eIF4F Complex.
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#28eIF4F-like complexes formed by cap-binding homolog ...
eIF4F -like complexes formed by cap-binding homolog. TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma ...
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#29Characterization of Arabidopsis thaliana translation initiation ...
Two vital components of this system are eukaryotic initiation factors (eIF) 4E and 4G, which together form the complex eIF4F. eIF4E is the cap-binding ...
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#30Plant eIF4B, eIF4F, and eIF(iso)4F Differentially Promote
eIF4F but is composed of the genetically distinct sub- ... Differential Translation of mRNA by eIF4B and eIF4F Isoforms. Plant Physiol. Vol. 150, 2009.
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#31Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G ... - JoVE
Critical for the assembly of active eIF4F complexes is the protein-protein interaction between eIF4E and eIF4G proteins. In this article, we ...
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#32Formation of the cap-binding eIF4F complex - Reactome ...
eIF4A interacts with eIF4G, and eIF4E interacts with the amino-terminal domain of eIF4G to form the cap-binding complex eIF4F. Literature References ...
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#33Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G ...
eIF4F is a cap-binding complex involved in the mRNA-ribosome recruitment phase of translation initiation. In many cellular and pre-clinical model of cancers, ...
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#34The CXCR4-LASP1-eIF4F Axis Promotes Translation of ...
Suppression of eIF4F can also affect the maintenance, progression, and metastasis of breast cancer in in vivo models (36–38). Elevated protein ...
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#35Dynamic changes in eIF4F-mRNA ... - Research Explorer
Abstract Background Translation factors eIF4E and eIF4G form eIF4F, which interacts with the messenger RNA (mRNA) 5′ cap to promote ribosome recruitment and ...
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#36Bunyavirus N: eIF4F surrogate and cap-guardian - Taylor ...
N has an activity that mimics or circumvents the cellular cap-binding complex, eIF4F, in the initial stages of translation initiation.
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#37RNA-binding protein FXR1 drives cMYC translation ... - X-MOL
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. Cell Rep. Pub Date : 2021-11-02
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#38Dynamic changes in eIF4F-mRNA interactions revealed by ...
BACKGROUND: Translation factors eIF4E and eIF4G form eIF4F, which interacts with the messenger RNA (mRNA) 5' cap to promote ribosome ...
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#39Targeting eIF4F Translation Initiation Complex in order to ...
One of the most frequently transformed signaling networks in cancer is the PI3K/mTOR /eIF4F signaling pathway. Through harmonized regulation of mTOR and ...
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#40mTORC1 and CK2 coordinate ternary and eIF4F complex ...
Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation and the ...
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#41Many roads from mTOR to eIF4F - Portland Press
The eIF4F mRNA cap-binding complex is also a conserved and ubiquitous ... The core components of eIF4F are: eIF4E, a protein that directly ...
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#42Disruption of the eIF4F translation initiation complex as a ...
8082 Background: Enzastaurin (enza) is in ph 3 registration trials for DLBCL patients at high risk of relapse following R-CHOP therapy.
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#43Hantavirus protein replaces eIF4F - virology blog
Hantavirus protein replaces eIF4F. 22 January 2009. eif4f The cellular translation machinery is frequently modified in virus-infected cells.
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#44eIF4F 與致癌蛋白的相互作用 - 每日頭條
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer ... the eIF4E–eIF4G interactions shows that eIF4F complex formation is ...
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#45Targeting protein translation initiation for cancer therapy
The eIF4F complex, consisting of: (i) eIF4E, the cap-binding protein responsible for binding of eIF4F to the mRNA cap structure; (ii) eIF4A, ...
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#46Inhibition of eukaryotic host translation factors by virus
eIF4F consists of the cap-binding protein eIF4E, the RNA helicase eIF4A, and the adapter protein eIF4G. Viruses have evolved ways of interacting with the host ...
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#47eIF4E Antibody#9742 - Cell Signaling Technology
eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 ...
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#48eIF4E/eIF4G Interaction Inhibitor II, 4E1RCat - Calbiochem
... of eukaryotic translation initiation factor (eIF) 4F complex (eIF4F) as well as disrupts preformed eIF4F by competing against eIF4G for eIF4E binding.
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#49翻訳開始過程を標的としたタンパク質合成のファイン ... - 生化学
真核生物において，このeIF4F複合体はタンパク質の鋳型となるすべてのmRNA上に形成される高次複合体である．eIF4Eによる5′末端のcap構造認識に始まるeIF4F ...
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#50Translation Factors - Bio-Rad Antibodies
eIF4F is composed of the 5' mRNA cap binding protein (eIF4E), the scaffolding protein (eIF4G) and RNA helicase (eIF4A) (Bhat et al.
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#51eIF4E Protein Overview: Sequence, Structure, Function and ...
The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, ...
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#52eFFECTOR Therapeutics Provides Pipeline and ... - BioSpace
The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT and RAS-MEK pathways, ...
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#54eFFECTOR Therapeutics Provides Pipeline and Business ...
The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT and RAS-MEK pathways, ...
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#55eFFECTOR Therapeutics (EFTR) Issues Pipeline and ...
The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT and RAS-MEK pathways, ...
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#56Cfvi price target. Despite the recent correction, CFVI and ...
This industrial laser company's products go into a lot of exciting fields, including biomedical Its STRI product candidates target the eIF4F complex and its ...
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