雖然這篇eIF4A鄉民發文沒有被收入到精華區：在eIF4A這個話題中，我們另外找到其它相關的精選爆讚文章
eif4a 在 張子蕾 TzuLei Chang Instagram 的最佳解答
2020-05-09 19:22:26
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[爆卦]eIF4A是什麼？優點缺點精華區懶人包
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#1eIF4A - 維基百科，自由的百科全書
真核起始因子4A（英語：eukaryotic translation Initiation Factor 4A，簡稱為eIF4A）是一種ATP依賴性RNA結合蛋白，一種RNA依賴性ATP酶，和一種RNA解旋酶，它在真核 ...
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#2The DEAD-box helicase eIF4A - NCBI
由 AZ Andreou 著作 · 2013 · 被引用 126 次 — The translation initiation factor eIF4A is the founding member of the DEAD-box protein family, and one of the few examples of DEAD-box proteins that consist of ...
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#3EIF4A1 - Eukaryotic initiation factor 4A-I - UniProt
In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding ...
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#4Eukaryotic initiation factor 4A (eIF4A) during viral infections
The helicase eIF4A is part of the cellular eIF4F translation initiation complex. The main functions of eIF4A are to remove secondary complex ...
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#5eIF4A (C32B4) Rabbit mAb#2013 - Cell Signaling Technology
eIF4A, an eIF4 complex component that acts as an ATP-dependent RNA helicase, unwinds the secondary structure of the 5' mRNA untranslated region to mediate ...
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#6The RNA Helicase eIF4A Is Required for Sapovirus Translation
The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5′ untranslated region (UTR) of mRNAs.
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#7EIF4A1 Gene - GeneCards | IF4A1 Protein
EIF-4A-I; EIF4A-I; Eukaryotic Translation Initiation Factor 4A, ... In the current model of translation initiation, eIF4A unwinds RNA ...
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#8Initiation Factor 4A - an overview | ScienceDirect Topics
The eIF4F Complex. eIF4F comprises the cap binding protein, eIF4E, the helicase eIF4A, and the large scaffolding protein eIF4G (Figure 281.1).
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#9AT1G54270(EIF4A-2) - TAIR
Other names: EIF4A-2. Description (?) member of eIF4A - eukaryotic initiation factor 4A. Other Gene Models (?) AT1G54270.2 (splice variant) ...
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#10Structural basis for the enhancement of eIF4A helicase activity ...
The eukaryotic translation initiation factors 4A (eIF4A) and 4G (eIF4G) are crucial for the assembly of the translationally active ribosome.
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#11A helicase-independent activity of eIF4A in promoting mRNA ...
We show that, unexpectedly, mRNA recruitment is dependent on both the eukaryotic initiation factor (eIF) 4A DEAD-box helicase and ATP. This ...
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#12RNA-tethering assay and eIF4G:eIF4A obligate dimer design ...
As well, transcription of eIF4A1 is under MYC regulation, whereas that of eIF4A2 is not (12). eIF4A2 has also been identified as a host factor ...
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#13RNA G-quadruplexes cause eIF4A-dependent oncogene ...
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism ...
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#14Yeast eIF4A enhances recruitment of mRNAs regardless of ...
eIF4A is a DEAD-box RNA-dependent ATPase thought to unwind RNA secondary structure in the 5'-untranslated regions (UTRs) of mRNAs to promote ...
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#15Modulation of RNA Condensation by the DEAD-Box Protein ...
eIF4A reduces the formation of stress granules in cells d. Recombinant eIF4A1 inhibits RNA condensation in vitro in an. ATP-dependent manner.
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#16Dmel\eIF4A - FlyBase Gene Report
eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor.
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#176XKI: Crystal structure of eIF4A-I in complex with RNA bound ...
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.
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#18eIF4A, a target of siRNA derived from rice stripe virus ... - PLOS
eif4a1 mutants display slow growth, reduced lateral root formation, delayed flowering, and abnormal ovule development [2]. A T-DNA mutation of ...
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#19eIF4A Inhibitors Suppress Cell-Cycle Feedback Response ...
eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer.
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#20Discovery of an eIF4A Inhibitor with a Novel Mechanism of ...
Inhibition of eIF4A through this unique mechanism may offer new ... eIF4A is an ATP-dependent DEAD-box RNA helicase that binds and unwinds ...
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#21eif4a - List of Frontiers' open access articles
Original Research demonstrated that inhibition of the emerging drug target eIF4A with Rocaglamide A (RocA) was efficacious against. Published on Dec 6, 2019.
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#22Interaction of Translation Initiation Factor eIF4G with eIF4A in ...
The eIF4A-binding site was mapped to amino acids 542–883 of yeast eIF4G1. Expression in yeast cells of the eIF4G1 domain that binds eIF4A results in cell growth ...
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#23Rabbit anti-Human Eukaryotic initiation factor 4A-II Polyclonal ...
Buy anti-eIF4A-I antibody, Rabbit anti-Human Eukaryotic initiation factor 4A-II Polyclonal Antibody-NP_001958.2 (MBS715216) product datasheet at MyBioSource ...
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#24Transcriptome-wide characterization of the ... - Genome Biology
Using Silvestrol, a selective eIF4A inhibitor, we identify 284 genes that rely on eIF4A for efficient translation. Our screen confirmed several ...
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#25Eukaryotic initiation factor 4A (eIF4A) during viral infections
PDF | The helicase eIF4A is part of the cellular eIF4F translation initiation complex. The main functions of eIF4A are to remove secondary complex.
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#26Eukaryotic initiation factor eIF4A - Agrisera
eIF4A | Eukaryotic initiation factor eIF4A. AS19 4251 | Clonality: Polyclonal | Host: Rabbit | Reactivity: Arabidopsis thaliana, Lactuca sativa, ...
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#27Plasmids related to eIF4A - Addgene
Log in to subscribe to Addgene Alerts. Description eukaryotic translation initiation factor 4A. Also known as Dmel_CG9075, 2439, 9075, CG9075, Dm-eIF4A, ...
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#28The diverse roles of the eIF4A family: you are the company ...
The eIF4A (eukaryotic initiation factor 4A) proteins belong to the extensive DEAD-box RNA helicase family, the members of which are involved ...
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#29eIF4A moonlights as an off switch for TORC1 - EMBO Press
Upon eIF4A knockdown, cells fail to inactivate TORC1 signaling when amino acids are removed from the growth medium. eIF4A inhibits TORC1 in response to removal ...
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#30Thesis | Modulation of translation initiation by eIF4A | ID
La protéine helicase eIF4A défait les structures secondaires de l'ARNm pour faciliter l'attachement de la sous unité ribosomique 40S. eIF4A a ...
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#31Dynamic Phosphorylation of Yeast eIF4A Drives Changes in ...
The eukaryotic translation initiation factor 4A (eIF4A) supports mRNA recruitment to the ribosomal preinitiation complex through activity of ...
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#32Full article: eIF4B stimulates eIF4A ATPase and unwinding ...
The ATPase and helicase activities of eIF4A are jointly stimulated by eIF4G and the translation initiation factor eIF4B. Yeast eIF4B mediates recruitment of the ...
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#33Wheat Eukaryotic Initiation Factor 4B Organizes Assembly of ...
eIF4A serves as an RNA helicase thought to unwind any secondary structure ... In addition to stimulating eIF4A activity, eIF4B mediates mRNA binding to ...
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#34eIF4A RNA Helicase Associates with Cyclin-Dependent ...
Eukaryotic initiation factor 4A (eIF4A) is a highly conserved RNA-stimulated ATPase and helicase involved in the initiation of.
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#35Investigation of the Biological Effect of eIF4A Reduction and ...
One protein involved in this process is the eukaryotic initiation factor 4A (eIF4A), an RNA helicase that is integral for cap-dependent translation ...
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#36Role of eIF4A in mRNA recruitment to the initiating ribosome
Next, we attempted to connect eIF4A ATPase with mRNA unwinding but despite numerous approaches, we could not directly monitor eIF4A helicase activity in the ...
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#37Targeting the DEAD-Box RNA Helicase eIF4A with ... - MDPI
Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics · Gaspar Taroncher ...
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#38Broad-spectrum Antiviral Activity of eIF4a Inhibitors - Memorial ...
CR-31B, one such Silvestrol analog, targets eIF4A, an RNA helicase and translation initiation factor. Researchers from MSK and the University of Marburg ...
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#39The requirement for eukaryotic initiation factor 4A (eIF4A) in ...
The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure - Volume 7 ...
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#40A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated ...
Most notably, we discovered that eIF4A, an RNA helicase, elicits potent non-canonical effects on the LEF1 IRES.
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#41Inhibiting eIF4A in liposarcoma to identify key regulators using ...
We focused specifically on the activity of eIF4A RNA helicase, a key translational factor in the eIF4F complex of the cap-dependent translation.
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#42eIF4A inhibition circumvents uncontrolled DNA replication ...
Importantly, targeting protein synthesis by eIF4A inhibitors circumvents PDAC resistance to mTOR inhibition. Introduction. Pancreatic ductal ...
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#43Targeting eIF4A Using MZ-735 Potently Induces Cell Death in ...
Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C- ...
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#44Anti-EIF4A Antibody Products | Biocompare
EIF4A is a reported alias name for the human gene EIF4A2, or 'eukaryotic translation initiation factor 4A2'. The 407-amino acid protein is a member ...
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#45Eukaryotic translation initiation factor 4A - Society for ...
eIF4A and eIF3 are stringently required for translation of the ecdysone target Mical, and this depends on the 5' UTR of Mical mRNA. Functional ...
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#46Structural Studies on the eIF4A-eIF4G Interaction in ...
Protein synthesis is an important cellular process, and the RNA helicase eIF4A plays a vital role in unwinding messenger RNA and scanning during translation ...
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#47Analysis and use of the tobacco eIF4A-10 promoter elements ...
The eIF4A gene family codes for proteins which unwind secondary structures of mRNA during translational initiation. The tobacco eIF4A-10 promoter is one of ...
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#48eIF4A | Cardio-Oncology and Medicinal Chemistry
The helicase eiF4A belongs to the eIF4F complex that regulates cap-dependent mRNA translation and represents an emerging target in oncology.
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#49Glucose depletion inhibits translation initiation via eIF4A loss ...
The mechanism and consequences of the translational inhibition caused by glucose depletion in yeast are characterized. eIF4A is lost from ...
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#50Factor-dependent processivity in human eIF4A DEAD-box ...
eIF4A has been thought to unwind structures formed in the untranslated 5′ region via a nonprocessive mechanism. Using a single-molecule assay, we found that ...
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#51eIF4A阻害の多様なメカニズム - 生化学
eIF4A を介する翻訳阻害. 翻訳開始因子は生物にとって必須な因子であるので，遺伝学的な解析が難しい側面がある．しかし ...
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#52小分子rocaglateは翻訳開始因子eIF4AをRNA配列に対し選択的 ...
真核生物翻訳開始因子のひとつeIF4AはDEADボックス型RNAヘリカーゼであり，5'側非翻訳領域においてRNAの2次構造を解きほぐすことによりリボソーム小サブユニットによる ...
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#53Role of Exosomes in Immune Microenvironment of ... - Hindawi
lncRNA SENP3-EIF4A [33. J. Wang, J. Pu, Y. Zhang et al., “Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular ...
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#54plitidepsin clinical trials. 2022-1-11 · MADRID, Jan - Boutique ...
Zotatifin inhibits the eukaryotic translation initiation factor 4A (eIF4A) (2). 2021-1-27 · The preclinical efficacy shown in this study and in a phase 1/2 ...
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#55eiq software. Prior to this, Jamie lead System Optimization ...
Here, we present the crystal structures of an N-terminal-truncated Pdcd4 in free form and in complex with eIF4A Whatever you need, Cubase helps you to reach ...
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#56isis initiation process. For we are but “a little lower than the ...
The 43S pre-initiation complex—formed of the 40S ribosomal eIF4A-mediated unwinding of 5' UTR higher-order structures as part of the eIF4F complex and ...
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#57prime factors of 185. Using the fraction 8/12 from above, we ...
Two highly homologous forms of functional EIF4A genes, Eif4a1 (602641) and Eif4a2, have been isolated in mice (Nielsen and Trachsel, 1988); yeast cells also ...
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#58bp3 protein. 3. 9 kDa cysteine-rich secreted protein. J:47951 ...
... the 5′ cap binding protein; eIF4A, an ATP-dependent RNA helicase; and eIF4G, a large Insulin-like Growth Factor-Binding Protein 3 (IGF-BP3) belongs to ...
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#59plitidepsin clinical trials. The trial met the primary safety ...
Zotatifin inhibits the eukaryotic translation initiation factor 4A (eIF4A) (2). Initially, plitidepsin underwent a large clinical development program in ...
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#60eiq software. EIQ-244KMHDR. electriQ. r. The company has ...
Here, we present the crystal structures of an N-terminal-truncated Pdcd4 in free form and in complex with eIF4A Whatever you need, Cubase helps you to reach ...
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#61無題
26, 2015 /PRNewswire/ -- Isis Pharmaceuticals, Inc. The 43S pre-initiation complex—formed of the 40S ribosomal eIF4A-mediated unwinding of 5' UTR ...
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