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#1Properdin - Wikipedia
Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying humans ...
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#2Properdin - an overview | ScienceDirect Topics
Properdin is the only gene of the complement system that is encoded on the X chromosome. Properdin stabilizes the alternative pathway C3 and C5 convertases by ...
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#3Structural Basis for Properdin Oligomerization and Convertase ...
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in ...
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#4Properdin: emerging roles of a pattern-recognition ... - PubMed
由 C Kemper 著作 · 2010 · 被引用 256 次 — Properdin, a plasma component that is also released by activated neutrophils, is critical in the stabilization of alternative pathway convertases. Recently, it ...
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#5Properdin: a tightly regulated critical inflammatory modulator
Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and positively regulate alternative ...
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#6CFP - Properdin precursor - Homo sapiens (Human) - UniProt
A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase ...
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#7Structure and function of a family of tick-derived complement ...
Properdin natively forms oligomers (Supplementary Fig. 1) which promote assembly of the C3bB proconvertase and stablise the AP C3 convertase ...
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#8300383 - COMPLEMENT FACTOR PROPERDIN; CFP - OMIM
Properdin (factor P) is a plasma protein that is active in the alternative complement pathway of the innate immune system. It is a positive regulatory ...
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#9Properdin homeostasis requires turnover of the ... - PNAS
At inflammatory sites it can bind bacteria and apoptotic bodies to trigger alternative pathway (AP) activation. Principles governing properdin homeostasis are ...
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#10The role of properdin in complement-mediated renal diseases
Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by ...
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#11Recombinant Human Properdin Protein, CF - R&D Systems
Human Properdin protein (8216-PR) is manufactured by R&D Systems, over 95% purity. Reproducible results in bioactivity assays. Learn More...
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#12Anti-Properdin Antibody (C-4): sc-365664 - Santa Cruz ...
Properdin Antibody (C-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml; raised against amino acids 289-469 mapping at the ...
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#13Properdin, Human, ELISA kit | Hycult Biotech
Properdin, or factor P, is a single-chain plasma glycoprotein (apparent molecular mass 52-55 kDa), consisting of six thrombospondin repeat sequences between ...
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#14Functional and structural insight into properdin control of ...
Properdin (FP) is an essential positive regulator of the complement alternative pathway (AP) providing stabilization of the C3 and C5 convertases, ...
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#15Properdin Antibody (PA5-95544) - Thermo Fisher
Invitrogen Anti-Properdin Polyclonal, Catalog # PA5-95544. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications.
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#16Properdin Definition & Meaning - Merriam-Webster
The meaning of PROPERDIN is a blood serum protein that participates in the activation of complement in a pathway which does not involve the presence of ...
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#17The Role of Properdin in the Assembly of the Alternative ...
Properdin is a positive regulator of complement activation that stabilizes the alternative pathway convertases (C3bBb).
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#18Human Properdin Protein, His Tag - ACROBiosystems
Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- ...
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#19The Role of Properdin in C5 Convertase Activity and C5b-9 ...
The Role of Properdin in C5 Convertase Activity and C5b-9 Formation in the Complement Alternative Pathway. Marloes A. H. M. Michels, Rianne ...
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#20A Novel Antibody against Human Properdin Inhibits ... - PLOS
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin ...
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#21AN ALTERNATIVE MECHANISM FOR THE PROPERDIN ...
Evidence is presented that phenomena ascribed to the properdin system may be explained in terms of classical antibody (Ab) in combination with three of the ...
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#22Properdin oligomers adopt rigid extended conformations ...
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of ...
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#23Factor P (Properdin) - Complement Technology
Complement factor P (properdin) is purified from normal human serum. Factor P is a 53,000 dalton cationic protein that circulates in blood in the form of ...
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#24Primary Immunodeficiency Diseases: Definition, Diagnosis, ...
Properdin stabilizes the C3bBb complex. This complex may activate many C3 molecules, which can combine with factor B, be activated by factor D and thus form ...
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#25Properdin Level Assay - Molecular Otolaryngology and Renal ...
Properdin Level Assay Properdin is a single chain plasma glycoprotein (MW: 58 kDa) mainly secreted by white blood cells including monocytes, lymphocytes and ...
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#26Blocking Properdin Prevents Complement-Mediated ...
Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia. Yoshiyasu Ueda, Takashi Miwa, Damodar Gullipalli, Sayaka ...
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#27Anti-Properdin/PFC antibody (ab186834) | Abcam
Rabbit polyclonal Properdin/PFC antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Independently reviewed in 1 review(s).
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#28Properdin Protein Overview: Sequence, Structure, Function ...
Properdin (factor P) is a plasma protein that is active in the alternative complement pathway of the innate immune system. It is a positive regulatory ...
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#29Anti-Properdin Antibody | ABF185 - Merck Millipore
This Anti-Properdin Antibody is validated for use in Western Blotting for the detection of Properdin. - Find MSDS or SDS, a COA, data sheets and more ...
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#30Properdin Definition & Meaning | Dictionary.com
Properdin definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
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#31Local release of properdin in the cellular microenvironment
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway (AP) convertases and as a ...
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#32Role of properdin in complement-mediated kidney diseases
Properdin was discovered in 1954 and is composed of six to seven thrombospondin repeats. By its interaction with C3b and Bb, it stabilizes the C3 convertase ...
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#33Properdin: Emerging Roles of a Pattern-Recognition Molecule
Importantly, properdin binding is independent of complement activation because concomitant C3b deposition is not observed. Minimal properdin is ...
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#346RUS: Structure of a functional properdin monomer - RCSB PDB
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in ...
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#35Anti-Properdin Antibody from rabbit, purified by affinity ...
Anti-Properdin Antibody from rabbit, purified by affinity chromatography; Synonyms: Complement factor P, Properdin; find Sigma-Aldrich-ABF185 MSDS, ...
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#36Recruitment of properdin by bi-specific nanobodies activates ...
Properdin (FP) functions as a positive complement regulator by stabilizing the alternative pathway C3 convertase. Here, we explore a novel strategy for direct ...
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#37PROPERDIN AND NATURAL IMMUNITY - JAMA Network
The protein is a euglobin with a molecular weight about eight times that of the gamma globulins, and it has been named properdin. On assaying the serum of ...
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#38The role of properdin in infection and inflammation - UKRI ...
Properdin is a key molecule of the innate immune response. It stabilises inherently labile convertases of the alternative pathway of complement activation and ...
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#39Properdin - Svar Life Science
Investigation of complement deficiency. Properdin should always be analyzed in patients with meningococcal disease. Immunoelectrophoresis Results are given ...
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#40Properdin | Profiles RNS
Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
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#41IHC-plus™ Properdin / CFP Polyclonal Antibody Rabbit anti ...
IHC-plus™ Properdin / CFP Antibody LS-B6914 is a pathologist validated IHC antibody Rabbit anti-Human Properdin / CFP. Validated for IHC,WB.
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#42Targeting properdin - Structure and function of a novel family ...
Targeting properdin - Structure and function of a novel family of tick-derived complement inhibitors. Katharina Braunger, Jiyoon Ahn, ...
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#43Human Properdin Recombinant Protein - Boster Bio
Recombinant human Properdin protein expressed in E.coli with His-Tag. Sequence domain: 28-469aa. Suitable applications: SDS-PAGE, Denatured.
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#44Properdin definition and meaning | Collins English Dictionary
Properdin definition: a protein present in blood serum that, acting with complement , is involved in the... | Meaning, pronunciation, translations and ...
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#45Activation of the Properdin Pathway of Complement in ...
Levels of properdin, factor B and C3, C5, C6, and C9 were significantly (p < 0.05) decreased in patients with shock in comparison with those ...
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#46Cfp (complement factor properdin) - Rat Genome Database
Predicted to be located in extracellular space; plasma membrane; and secretory granule. Human ortholog(s) of this gene implicated in X-linked properdin ...
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#47The complement factor properdin induces formation of platelet ...
Both the complement system and platelet-leukocyte aggregates are involved in chronic and acute stages of atherosclerosis. Properdin, a positive regulator of ...
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#48Activator-specific requirement of properdin in the initiation and ...
The current understanding of properdin function is that it facilitates AP complement activation by stabilizing the C3 convertase C3bBb.
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#49Recombinant monomeric human Properdin - SASDB59
Functional and structural insight into properdin control of complement alternative pathway amplification. Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, ...
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#50Combination of Factor H Mutation and Properdin Deficiency ...
Purpose : Both factor H (fH) and properdin (fP) regulate complement. fH is a complement inhibitor, while fP activates the alternative pathway (AP).
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#51II. Interaction of the Properdin System with Polysaccharides
HESTRIN, S, INFECTION-PROMOTING ACTIVITY OF LEVAN AND DEXTRAN AS A FUNCTION OF DEGREE OF POLYMERIZATION, BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY 35: 107 (1954) ...
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#52| List of sources of properdin. | Download Table - ResearchGate
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway (AP) convertases and as a ...
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#53Properdin factor B - RCPA
Properdin factor B. Specimen: 10 mL blood in plain tube. Specimen transported on melting ice. Method ...
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#54Neisseria meningitidis inside neutrophils, revealing properdin ...
et al. Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils.
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#55Linkage Specificity and Role of Properdin in Activation of the ...
Finally, properdin binding to glucan particles (GP) and zymosan in serum required active C3. Properdin colocalized with bound C3, suggesting ...
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#56Cfp MGI Mouse Gene Detail - MGI:97545 - complement factor ...
complement factor properdin. Synonyms. Pfc. Feature Type. protein coding gene. IDs. MGI:97545. NCBI Gene: 18636. Alliance.
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#57Myeloperoxidase Directs Properdin-Mediated Complement ...
Properdin can also bind to nonapoptotic/necrotic cells, such as the surface of viable stimulated neutrophils, allowing for complement activation ...
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#58Properdin Deficiency disease - MalaCards
An important gene associated with Properdin Deficiency is CFP (Complement Factor Properdin). Affiliated tissues include monocytes, kidney and ...
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#59Complement Properdin Determines Disease Activity in MRL ...
Properdin is the only known positive regulator of complement activation, but its role in the severity of lupus nephritis has not been studied yet.
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#60Properdin System and Immunity. II. Interaction and the ... - jstor
abnormal red cells (5). The observation that zymosan (6), an insoluble carbohy- drate complex derived from yeast cell walls, combines with the properdin at.
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#61Properdin binds independent of complement activation in an ...
To better understand the role of properdin in vivo, we used an experimental model of acute anti-glomerular basement membrane disease with wild- ...
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#62Properdin - wikidoc
Properdin is a gamma globulin protein composed of multiple identical protein subunits with a separate ligand-binding site. Native properdin ...
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#63Prognostic Value of Complement Properdin in Cancer - Italian ...
In addition, properdin promotes the phagocytic uptake of apoptotic T cells by macrophages and dendritic cells without activating the ...
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#64Metabolism of properdin in normal subjects and patients with ...
Properdin deposition has been recognized in glomeruli of patients with acute and chronic nephritis and lupus nephritis, and low serum properdin levels have ...
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#65Human Properdin Released By Infiltrating Neutrophils Can ...
Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads to the formation of C5 convertase, ...
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#66Properdin has an ascendancy over factor H regulation in ...
... of complement AP activation in patients with renal tubular damage by focusing on the balance between properdin (P) and factor H (fH).
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#67Targeting properdin in the treatment of atypical haemolytic ...
Targeting properdin in the treatment of atypical haemolytic uraemic syndrome: better than eculizumab? Kate Smith-Jackson, Kevin J. Marchbank ...
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#68PROPERDIN English Definition and Meaning | Lexico.com
'It has developed proprietary monoclonal antibodies to properdin that are potent in vitro and in vivo inhibitors of the complement alternative pathway.'.
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#69Properdin - The Free Dictionary
properdin. (ˈprəʊpədɪn). n. (Medicine) immunol a protein present in blood serum that, acting with complement, is involved in the destruction ...
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#70Properdin - DocCheck Flexikon
Properdin ist ein Gammaglobulin, das eine wichtige Rolle bei der Steuerung des Komplementsystems spielt. Es stabilisiert die Proteasen der alternativen ...
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#71CONCERNING THE NATURE OF THE PROPERDIN SYSTEM
The properdin system, which is composed of properdin, magnesium and complement, has a variety of activities in vitro. Among these are the lysis of certain ...
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#72Medline ® Abstract for Reference 48 of 'Mechanisms of ...
48: PubMed |; TI: Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. AU: Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, ...
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#73Primary Immunodeficiency Disorders: A Historic and ...
The zymosan appeared to interact with a previously undescribed serum protein that they termed properdin. Properdinmediated C3 activation occurred in the ...
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#74[PDF] THE PROPERDIN SYSTEM AND IMMUNITY - Semantic ...
It is demonstrated that the removal of properdin from serum also removes bactericidal activity, and that, in addition to properdin, the four components of ...
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#75Properdin Is a Key Player in Lysis of Red Blood Cells and ...
Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation.
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#76CFP is a prognostic biomarker and correlated with immune ...
Complement factor properdin (CFP), encodes plasma glycoprotein, is a critical gene that regulates the complement pathway of the innate immune system.
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#77Macromolecular Structure Underlying Recognition in Innate ...
FIGURE 8 | Carboxymethyl cellulose-coated carbon nanotubes (CMC-CNTs) coated with properdin or thrombospondin type I repeat (TSR) 4 + 5 cause translocation ...
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#78Prognostic Value of Complement Properdin in Cancer - Brunel ...
Keywords: properdin;innate immunity;bioinformatics analysis;cancer;prognostic marker. Issue Date: 19-Jan-2020. Publisher: Frontiers Media S.A..
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#79Complement Deficiencies
Properdin makes it possible for the amplification loop of the alternative pathway to set up a very efficient mechanism for putting lots of C3b onto the surface ...
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#80Bibliography of Medical Reviews - 第 6 卷 - 第 330 頁 - Google 圖書結果
Curr Ther Res 2 : 199-226 , Jun 60 Propanol see ALCOHOL , PROPYL LEGRAMANTE A , COSSU M : [ Biological importance of properdin and its clinical value ] Clin ...
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#81Germfree Life And Gnotobiology - 第 378 頁 - Google 圖書結果
Properdin, Pillemer (1956) found properdin to be present in the serum of germfree rats. This experiment was elaborated by Wagner (1959b), whose data (Table ...
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#82Cytolytic Lymphocytes and Complement Effectors of the Immune ...
... I, and properdin, and the membrane-associated proteins DAF and CR1. All of these regulators are inhibitors of activation except properdin.
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#83Change of total protein, protein fractions, sialic acid level, and ...
Change of total protein, protein fractions, sialic acid level, and properdin in calves' blood serum after immunization = [1981]. Nriev, G. G.; ...
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#84Complement System - Piet Gros Lab
Activation states of C3; Serine protease factor B; Convertase formation; C3 convertase activity and specificity; Enhancing complement activity by properdin ...
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#85Issues in Immunology Research: 2011 Edition
Investigators publish new data in the report 'Properdin: emerging roles of a pattern-recognition molecule.' “Complement is an innate immune system that is a ...
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#86Cumulated Index Medicus - 第 16 卷 - 第 5372 頁 - Google 圖書結果
Br J Obstet Gynaecol 82 ( 4 ) : 285-8 , Apr 75 PROPERDIN cun Pharmacol Ther 17 ( 4 ) : 400-8 , Apr 75 The effect of intravenous ritodrine on the acid - base ...
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#87Rene - Patologia generale - 608199 - Università di Foggia
18 osservati depositi di solo C3 e properdina, privi degli elementi precoci della cascata (C4 C2). Presenza di Fattore nefritico (del tipo II) in alcuni ...
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