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[爆卦]IRF5是什麼？優點缺點精華區懶人包
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#1IRF5 - Wikipedia
Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. ... The IRF family is a group of transcription factors that are involved ...
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#2IRF5 gene: MedlinePlus Genetics
The protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) ...
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#3IRF5 Gene - GeneCards | IRF5 Protein | IRF5 Antibody
IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and ...
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#4IRF5 - Interferon regulatory factor 5 - Homo sapiens (Human)
"A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus ...
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#53663 - Gene ResultIRF5 interferon regulatory factor 5 [ (human)]
2022年2月6日 — IRF5 is an important tumor suppressor that regulates multiple cellular processes involved in the conversion of normal mammary epithelial cells ...
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#6Specific detection of interferon regulatory factor 5 (IRF5) - Nature
The interferon regulatory factor 5 (IRF5) gene encodes proteins that bind to DNA and regulate the transcription of genes important for innate ...
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#7Advances and challenges in targeting IRF5, a ... - FEBS Press
Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and ...
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#8Therapeutic Targeting of IRFs: Pathway-Dependence or ...
IRF5 was identified as a key regulatory factor for macrophage polarization. The activation of IRF5 expression in macrophages decides their fate ...
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#9RAW-Lucia™ ISG-KO-IRF5 Cells | IFN reporter macrophages
IRF5 can also be activated by the IKKβ kinase downstream of the MAVS adaptor associated with RIG-I or MDA5 [2]. IRF5 plays a key role in numerous inflammatory ...
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#10The Interferon Regulatory Factor, IRF5, Is a Central Mediator ...
由 A Schoenemeyer 著作 · 2005 · 被引用 450 次 — TLR7 and TLR8 Activate IRF5 and IRF7 but Not IRF3— Double-stranded RNA and LPS induce type I IFN gene expression via the adapter molecule TRIF and the ...
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#11607218 - INTERFERON REGULATORY FACTOR 5; IRF5
INTERFERON REGULATORY FACTOR 5 ; IRF5. HGNC Approved Gene Symbol: IRF5. Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,937,031-128,950,037 ...
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#12Regulation and role of the transcription factor IRF5 in innate ...
Abstract. The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the ...
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#13IRF5 protein expression summary
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory ...
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#14Inhibition of IRF5 hyperactivation protects from lupus onset ...
IRF5 was originally identified as a regulator of type I IFNs (IFNs) and IFN-stimulated genes (ISGs) in response to virus infection (1–3). Subsequent studies ...
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#15Interferon regulatory factor 5 (IRF5) gene variants are ...
Background: IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been ...
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#16IRF5 Promotes Influenza Virus-Induced Inflammatory ...
Thus, IRF5 acts as a regulator of myeloid cell inflammatory cytokine production during IAV infection in mice and humans and drives immune- ...
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#17MGI:1350924 - interferon regulatory factor 5 - Mouse Genome ...
View mouse Irf5 Chr6:29526624-29541870 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression.
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#18IRF5 Antibody (PA5-79518) - Thermo Fisher
Invitrogen Anti-IRF5 Polyclonal, Catalog # PA5-79518. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Immunohistochemistry (Paraffin) (IHC ...
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#19Human IRF5 Antibody AF4508 - R&D Systems
Detects human IRF5 in Western blots. Source. Polyclonal Sheep IgG. Purification. Antigen Affinity-purified. Immunogen. E.
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#20IKKβ is an IRF5 kinase that instigates inflammation | PNAS
Similar to IRF3 and IRF7, IRF5 contains a DNA-binding domain (DBD), an IRF-association domain (IAD), and a serine-rich region (SRR) at the C ...
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#21IRF-5 (E1N9G) Rabbit mAb #13496 - Cell Signaling Technology
Monoclonal Antibody for studying IRF-5 in the research area.
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#22Rabbit anti-IRF5 Antibody - Fortis Life Sciences
Rabbit anti-IRF5 Antibody. ... Interferon regulatory factor 5 (IRF5) is a member of the IRF family of transcription factors that plays a critical role in ...
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#23Purified anti-IRF5 Antibody anti-IRF-5 - 11F4A09 - BioLegend
Purified anti-IRF5 Antibody - IRF-5 is a transcription factor belonging to the interferon regulatory factor family.
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#24Interferon regulatory factor 5 (IPR029838) - InterPro entry
Variations of the IRF5 gene affects the susceptibility of a few diseases, such as inflammatory bowel disease 14 (IBD14) ·, systemic lupus erythematosus 10 ( ...
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#25irf5 - ZFIN Gene
irf5. ID: ZDB-GENE-040426-2587; Name: interferon regulatory factor 5; Symbol: irf5 Nomenclature History; Previous Names. im:7155364; zgc:76986.
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#26Activation of Interferon Regulatory Factor 5 by Site Specific ...
Interferon regulatory factor 5 (IRF5), a risk factor for systemic lupus erythematosus, is activated in response to pathogen recognition receptor ...
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#27IRF5 (human) - PhosphoSite
IRF5 Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 ...
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#28Gene: IRF5 (ENSG00000128604) - Summary - Ensembl
Gene: IRF5 ENSG00000128604 . twitter logo Twitter facebook logo Facebook email logo Email. Description. interferon regulatory factor 5 [Source:HGNC Symbol ...
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#29Human IRF5 ELISA Kit - MyBioSource
Buy IRF5 elisa kit, Human IRF5 ELISA Kit-NP_001229381.1 (MBS2507418) product datasheet at MyBioSource, ELISA Kits.
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#30Inhibition of IRF5 cellular activity with cell-penetrating peptides
The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream of Toll-, nucleotide-binding ...
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#31IRF5 antibody (10547-1-AP) | Proteintech
Cited in 29 publications. IRF5 antibody for FC, IF, IHC, IP, WB, ELISA and reacts with human, mouse, rat.
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#32IRF5 | SpringerLink
IRF5 is a critical mediator of the cellular response to extracellular stressors including virus, DNA damage, pathogenic stimuli (i.e., TLR ligands), and death ...
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#33Human IRF5 ELISA Kit (ab282878) | Abcam
Human IRF5 ELISA Kit is a single-wash 90-min SimpleStep ELISA® for the quantitative measurement of Human IRF5 in Cell Lysate samples.
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#34Irf5 siRNA-loaded biodegradable lipid nanoparticles ...
The therapeutic potential of Irf5 siRNA-loaded LNPs in inflammatory diseases was tested in a concanavalin A (Con A)-induced hepatitis model, ...
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#35Human Gene IRF5 (ENST00000489702.6) from GENCODE V38
PTM: 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation. DISEASE: Genetic variations in IRF5 are associated with susceptibility to ...
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#36IRF5 (interferon regulatory factor 5) - Atlas of Genetics and ...
IRF5 (interferon regulatory factor 5), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
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#37IRF5 (NM_032643) Human Tagged ORF Clone – RC200458
IRF5 (Myc-DDK-tagged)-Human interferon regulatory factor 5 (IRF5), transcript variant 2.
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#38Targeting IRF5 Activation for the Treatment of Lupus - Journal ...
One such transcription factor is interferon regulatory factor 5 (IRF5). Polymorphisms in the IRF5 gene have been one of the most strongly associated factors ...
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#39Expression IRF5-Mediated Proinflammatory Cytokine ...
Many of these genes have been shown to be regulated by transcription factors of the IFN regulatory factor (IRF) family. Recent studies from IRF5 knockout mice ...
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#40IRF5 Overexpression Lysate (NBL1-12034) - Novus Biologicals
Transient overexpression lysate of interferon regulatory factor 5 (IRF5), transcript variant 2 The lysate was created in HEK293T cells, using Plasmid ID ...
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#41HIV-2 Vpx Protein Interacts with Interferon Regulatory Factor 5 ...
Activation of IRF5 results in the production of pro-inflammatory cytokines such as TNFα, IL6, and IL12, as well as type I interferons.
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#42Irf5 (interferon regulatory factor 5) - Rat Genome Database
Symbol: Irf5. Name: interferon regulatory factor 5. RGD ID: 1310447. Description: Predicted to enable several functions, including DNA-binding transcription ...
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#433DSH: Crystal structure of dimeric interferon regulatory factor ...
3DSH ; Mutation(s): 1 ; Gene Names · IRF5 ; UniProt & NIH Common Fund Data Resources. Find proteins for Q13568 (Homo sapiens). Explore Q13568. Go to ...
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#44IRF5 is required for late-phase TNF secretion by human ...
We demonstrate that DCs but not macrophages have high levels of IRF5 protein, and that IRF5 is responsible for the late-phase expression of TNF, ...
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#45IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
Previously, our laboratory identified the transcription factor interferon regulatory factor 5 (IRF5) as the master regulator of the M1 macrophage polarisation.
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#46Interferon regulatory factor 5 genetic variants are associated ...
Three IRF5 polymorphisms (rs2004640, rs2070197 and rs10954213) representative of each haplotype group were genotyped by performing TaqMan ...
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#47Polyclonal Antibody - IRF5 | MRC-PPU Reagents
Full Name: IRF5 phospho Ser 462 ; Long Name Text: interferon regulatory factor 5 ; Immuno Sequence: IRLQIS*NPDLK [residues 457 - 467 of human] ; Phosphopeptide:.
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#48Anti-IRF5 Antibody (HPA046700)
Rabbit Polyclonal Anti-IRF5 Antibody against Human interferon regulatory factor 5. Validated for Western Blot.
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#49IRF5 - LSBio
IRF5 is a member of the interferon regulatory factor (IRF) ... IRF5 Antibody - IHC of paraffin-embedded Human Kidney tissue using ...
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#50IRF5 monoclonal antibody, clone 10T1 - (MAB1068) - Products
Mouse monoclonal antibody raised against partial recombinant IRF5. Recombinant protein corresponding to amino acids 176-240 of human IRF5.
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#51Expression of interferon regulatory factor 5 is regulated by the ...
Abstract. The transcription factor, interferon regulatory factor 5 (IRF5), is important in the induction of type I.
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#52Association of the IRF5 SNP rs2004640 with Systemic ...
Systemic sclerosis (SSc) is a complex disease involving multiple genetic factors. An association of the IRF5 polymorphism with SSc was reported in Caucasian ...
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#53IRF5 CRISPR guide RNA - GenScript
The IRF5 CRISPR guide RNA sequences were designed by GenScript's proprietary algorithm to target a single locus in the endogenous genome.
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#54IRF5 is associated with adverse postoperative prognosis of ...
Research Papers: IRF5 is associated with adverse postoperative prognosis of patients with non-metastatic clear cell renal cell carcinoma.
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#55IRF5 Protein Human Recombinant | IRF-5 Antigen - Prospec Bio
IRF5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids and having a molecular mass of 10.7kDa.
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#56| The canonical IRF5 signaling pathway and its negative ...
(B) A negative feedback loop may also be involved in the suppression of IRF5-mediated inflammatory gene transcription. TAK1 initiates a series of ...
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#57IRF5 is increased in labouring myometrium and regulates pro ...
To determine if IRF5 regulates pro-labour mediators, transfection of primary myometrial cells with siRNA was performed as previously ...
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#58Interferon Regulatory Factor 5 (IRF5) Interacts with ... - bioRxiv
Consistent with this notion, we report the ability of IRF5 to control gene expression at the level of mRNA translation. Our findings demonstrate ...
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#59Symbol report for IRF5 - HUGO Gene Nomenclature Committee
IRF5. Approved name. interferon regulatory factor 5. Locus type. gene with protein product. HGNC ID. HGNC:6120. Symbol status. Approved. Alias symbols.
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#60Inflammation and Immunity in Cancer - 第 93 頁 - Google 圖書結果
transplantation experiments revealed that IRF5 is required in cells of the hematopoietic origin for the control of tumor metastasis.
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#61Cancer: New Insights for the Healthcare Professional: 2011 ...
When compared with C57BL/6 mice, Irf5(-/-) mice show higher susceptibility to viral infection and decreased serum levels of type I IFN and the inflammatory ...
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#62Antigen-Presenting Cells: Advances in Research and ...
Data on mononuclear phagocyte system reported by researchers at College of Science, Kennedy Institute of Rheumatology A report, 'IRF5 is required for ...
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#63Issues in Genetic Medicine: 2013 Edition - 第 131 頁 - Google 圖書結果
This defect is due to the intrinsic deletion of IRF-5 in B cells, as SCID mice reconstituted with Irf5-/-B cells show a decrease in IgG2a/c expression after ...
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#64LynはToll様受容体-MyD88シグナル伝達経路において転写因子 ...
IRF5 は自然免疫応答において重要な転写因子である一方，自己免疫疾患である全身性エリテマトーデスの発症に関与することがヒトおよびマウスにおいて知られている．Src ...
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#65Reprogramming Interferon Regulatory Factor Signaling in ...
IRF5D blocks the expression and translocation of IRF5, the expression of ICAM-1, and the infiltration of myocardial inflammatory cells, ...
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#66The Immunology of Sepsis – Understanding Host ...
IRF5, a transcription factor implicated in M1 polarization, increases in the cytoplasm and in the nucleus during monocyte to M1 macrophage differentiation.
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#67Human and Oncoviral Noncoding RNAs as Modulators of Cancer ...
IRF5 -mediated immune responses and its implications in immunological disorders. Int Rev Immunol. (2018) 37:229–48. doi: 10.1080/08830185.2018.1469629 24.
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#68Nucleic Acid-Associated Inflammation - 第 61 頁 - Google 圖書結果
IRF5 -deficient mice or SLE model mice treated with an IRF5 inhibitor attenuated lupus pathology (180, 181). Ex vivo human studies demonstrated that an IRF5 ...
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#69Sjogren Syndrome: New Insights for the Healthcare ...
IRF5. in. primary. Sjogren's. syndrome ... by NewsRx correspondents, research stated, “The transcription factor interferon regulatory factor 5 (IRF5), ...
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#70Sjögren’s Syndrome: Practical Guidelines to Diagnosis and ...
Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE). Annl Hum Genet.
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#72自然免疫の過剰な反応を防ぐ新たなしくみを発見し - 大学 ...
研究成果のポイント・SrcファミリーキナーゼLynは、自然免疫応答を引き起こす役割を持つ転写因子IRF5の活性を阻害する。このことは免疫が過度に働くの ...
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#73New treatment for people with asthma, food allergies?
IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice. Timothy B. Oriss et al., ...
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#74José Luiz Proença Módena - Biblioteca Virtual da FAPESP
Professor livre docente (MS5.1) de Virologia do Departamento de Genética, Evolução, Microbiologia e Imunologia do Instituto de Biologia (IB) da Universidade ...
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#75C4550D107SV120RFSA2116.384MHZ ... - Datasheet
由于是大功率的，通过IRF540的电流会很大，必须给IRF5...[详细] · C51单片机与PC串口通信的单片机部分程序. 注意波特率是9600 功能：电脑通过串口给单片机发一个字节， ...
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