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[爆卦]irf5 macrophage是什麼？優點缺點精華區懶人包
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#1IRF5 promotes inflammatory macrophage polarization and ...
Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune ...
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#2IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
To conclude, this study clearly demonstrates that IRF5 is highly expressed in murine proinflammatory macrophages and may be utilised as a reliable marker for ...
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#3IRF5 Is a Key Regulator of Macrophage Response to ... - NCBI
IRF5, a transcription factor implicated in M1 polarization, increases in the cytoplasm and in the nucleus during monocyte to M1 macrophage ...
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#4IRF5 Is Required for Bacterial Clearance in Human M1 ...
We found that IRF5 was required for optimal bacterial clearance in PRR-stimulated, M1-differentiated human macrophages. Mechanisms regulated by ...
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#5IRF5 and IRF5 Disease-Risk Variants Increase ... - Cell Press
Interferon regulatory factor 5 (IRF5) regulates in- flammatory M1 macrophage polarization, and dis- ease-associated IRF5 genetic variants ...
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#6IRF5 promotes inflammatory macrophage polarization and ...
High levels of IRF5 are characteristic of M1 macrophages, in which it directly activates transcription of IL-12p40/p35, IL-23p19 genes and represses IL-10 gene.
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#7IRF5 promotes inflammatory macrophage polarization and ...
IRF5 promotes inflammatory macrophage polarization and T H 1-T H 17 responses Krausgruber, T.?nbsp;et al. Nat. Immunol.?nbsp;12, 231-2...
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#8Reprogramming macrophage orientation ... - ScienceDirect.com
由 L Peng 著作 · 2016 · 被引用 38 次 — Interleukin 10-induced miR-146b plays a critical role in the regulation of macrophage polarization and colitis development by targeting IRF5.
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#9IRF5 guides monocytes toward an inflammatory ... - Science
Interferon regulatory factor 5 (IRF5) is a transcription factor previously shown to play a key role in maintaining the inflammatory phenotype of macrophages.
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#10IRF5 regulates airway macrophage metabolic responses to ...
Recent work has shown that macrophage activation and plasticity are under metabolic control. Interferon regulatory factor 5 (IRF5) is a key transcription factor ...
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#11Macrophage-specific IRF5 deficiency stabilizes atherosclerotic ...
Interferon regulatory factor (IRF) 5 is a transcription factor promoting inflammatory macrophage polarization (M1 type).
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#12Interferon Regulatory Factor‐5 in Resident Macrophage ...
IFN regulatory factor 5 (IRF5) is a transcription factor that has recently been identified as a mediator of proinflammatory cytokine production ...
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#13In Vivo Silencing of the Transcription Factor ... - DSpace@MIT
Results Infarct macrophages expressed high levels of IRF5 during the early inflammatory wound-healing stages (day 4 after coronary ligation), whereas expression ...
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#14IRF5 governs liver macrophage activation that promotes ...
We have recently documented that the fifth member of the IRFs, IRF5, is expressed in myeloid cells and responsible for M1 macrophage ...
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#15IRF5 promotes inflammatory macrophage polarization and ...
Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases.
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#16IRF5 controls both acute and chronic inflammation | PNAS
We have shown that the transcription factor IFN regulatory factor 5 (IRF5) polarizes macrophages toward an inflammatory phenotype.
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#17Modulation of macrophage subtypes by IRF5 determines ...
Abstract Bone-resorbing osteoclasts are differentiated from macrophages (MΦ) by M-CSF and RANKL. MΦ can be mainly classified into M1 and M2 ...
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#18IRF5 Promotes Influenza Virus-Induced Inflammatory ...
IRF5 is expressed predominantly by myeloid cells such as dendritic cells (DCs) and macrophages, in addition to B cells (13, 18).
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#19IRF5 regulates lung macrophages M2 polarization during ...
Lung macrophages expressed high levels of IRF5 as M1 phenotype during the early acute pancreatitis stages. Reduction of IRF5 expression by IRF5 ...
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#20In vivo silencing of the transcription factor IRF5 reprograms the ...
Macrophage Phenotype and Improves Infarct Healing. ... Interferon Regulatory Factor 5 (IRF5) in cardiac macrophages improves infarct healing ...
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#21IRF5 Is a Key Regulator of Macrophage Response to ...
Newborn monocytes differentiated into M1 and M2 macrophages with similar ... of newborn macrophages and identify IRF5 as a key regulator of macrophage TNF ...
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#22RAW-Lucia™ ISG-KO-IRF5 Cells | IFN reporter macrophages
RAW-Lucia™ ISG-KO-IRF5 cells were generated from the mouse RAW-Lucia™ ISG macrophage cell line by stable knockout of the interferon regulatory factor 5 ...
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#23IRF5 promotes inflammatory macrophage polarization and...
This paper is interesting, since it reports the implication of the transcription factor IRF5 (interferon regulatory factor 5) in the control of macrophage ...
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#24Interferon regulatory factor-5-dependent CD11c+ ... - X-MOL
... (IRF5) drives macrophages towards a pro-inflammatory state. ... used to mine associations between major macrophage associated genes and ...
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#25181 m1 macrophages and irf5 exacerbate atherosclerotic ...
Interferon Regulatory Factor 5 (IRF5) has been shown to be instrumental for M1 macrophage polarisation. We aimed to establish the occurrence of macrophage ...
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#26BCG Increased Membrane Expression of TRIM59 Through the ...
... we showed that Bacillus Calmette-Guerin (BCG)- activated macrophages have the ... of TRIM59 Through the TLR2/ TLR4/IRF5 Pathway in RAW264.7 Macrophages.
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#27In Vivo Silencing of the Transcription Factor ... - JACC Journals
IRF5 augments inflammatory gene expression in macrophages, and this transcription factor regulates macrophage polarization (13). Its expression in myocardial ...
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#28Mangiferin inhibits macrophage classical activation via ...
Macrophage classical activation is important role in the process of bronchial airway inflammation, and interferon regulatory factor 5 (IRF5) ...
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#29Thalidomide Attenuates Colitis and Is Associated with the ...
Thalidomide controls M1 macrophage polarization by targeting the transcription factor IRF5. Finally, by using the classical AOM/DSS model, we ...
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#30The IKZF1–IRF4/IRF5 Axis Controls Polarization of Myeloma ...
Therefore, it is important to develop means for targeting the multiple myeloma bone marrow microenvironment. Myeloma-associated macrophages (MAM) in the bone ...
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#31Reprogramming macrophage orientation by ... - VTechWorks
Our data show that miR-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR-146b deficient mice developed intestinal ...
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#32Repetitive Intermittent Hyperglycemia Drives the M1 ... - MDPI
The role of IRF5 in proinflammatory M1 macrophage polarization has been well documented [16,17]. Macrophages are regarded as the central ...
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#33IRF5 Is a Key Regulator of Macrophage Response to ... - Serval
In line with a functional role for IRF5, adenoviral-mediated IRF5 overexpression in newborn M1 macrophages restored lipopolysaccharide-induced ...
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#34PYK2 controls intestinal inflammation via activation of IRF5 in ...
A screen of a protein kinase inhibitor library in macrophages revealed a list of putative IRF5 kinases. Among the top hits validated in ...
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#35IRF5 is increased in labouring myometrium and regulates pro ...
Interferon regulatory factor 5 (IRF5) has recently emerged as an important ... 2016 IRF5 governs liver macrophage activation that promotes ...
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#36IRF5 promotes inflammatory macrophage - ProQuest
Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization ...
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#37Mechanism of Iron Oxide-Induced Macrophage Activation
This result demonstrated that magnetite-induced M1 macrophages only achieved phenotype from IRF5 activation but not from iNOS, ...
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#38IRF5 and Macrophage Activation Syndrome in systemic ...
MAS secondary to sJIA and to viral infection is associated with variants in the gene encoding IRF5, a transcription factor activated downstream of TLR signaling ...
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#39Review of: "Myeloid cell-specific Irf5 deficiency ... - Qeios
Moreover, bone marrow-derived macrophage accumulation, proliferation and lipid uptake was decreased in plaque macrophages (Leipner et al., 2021). The here used ...
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#40Science子刊：IRF5促進炎症性巨噬細胞的產生以調控腸道炎症
①小鼠的IRF5缺失不影響穩態下的結腸生理，但可在腸道炎症中起到保護性作用。 ② IRF5不影響骨髓及血液中的單核細胞發育，對穩態下的CD11c+腸道巨噬細胞也 ...
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#41Interferon Regulatory Factor 5 Controls Necrotic Core ...
IRF5 is detrimental in atherosclerosis by promoting the maintenance of proinflammatory CD11c + macrophages within lesions and controlling the ...
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#42Association of IRF5 Polymorphisms with Susceptibility to ...
Objective. Systemic-onset juvenile idiopathic arthritis (systemic JIA) and macrophage activation syndrome (MAS), the most devastating ...
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#43Research Article IRF5 Is a Specific Marker of Inflammatory ...
inflammatory M2 macrophages. Previously, our laboratory identified the transcription factor interferon regulatory factor 5 (IRF5).
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#44Understanding the PROtectiVe Inflammation in DiabEtes | ANR
We observed that specific pathways controlled by IRF5 in macrophages orchestrate a “protective” immune response in adipose tissue and might have a similar ...
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#45Monocyte differentiation and macrophage polarization
Monocyte, macrophage, differentiation, polarization, inflammatory M1 phenotype, ... and nuclear translocation of transcription factors IRF5 and NF-κB.
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#46Mini-review: Macrophage Polarization - Bio-Rad Antibodies
Macrophage polarization review exploring the function and phenotype of M1, ... M1 macrophages have been shown to upregulate IRF5, which is critical for M1 ...
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#47IRF5 promotes inflammatory macrophage polarization and T ...
IRF5 promotes inflammatory macrophage polarization and T H1-TH17 ... Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory ...
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#48M2 to M1; macrophage reprogramming can be done! - ACIR.org
To reprogram macrophages from an M2 to an M1 phenotype, ... regulatory factor 5 (IRF5), which can drive macrophage polarization towards M1.
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#49Macrophage Polarization in Inflammatory Diseases
Those include the activation of STAT1 mediated by IFN-γ receptor, increase in IRF5, NF-κB, as well as AP1 expression mediated by Toll-like receptor 4 (TLR4), ...
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#50The Pivotal Role of Macrophages in Metabolic Distress
It was also shown that IRF5 promotes inflammatory macrophage polarization by activating the transcription of IL-12 and repressing IL-10 [55].
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#52Macrophages: Biology and Role in the Pathology of Diseases
... Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA (2011) IRF5 promotes inflammatory macrophage polarization and TH1–TH17 responses.
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#53High expression of RRM1 mediated by ncRNAs correlates
... including B cells, CD8+T cells, CD4+T cells, macrophages, ... M1 macrophage (NOS2, IRF5, and PTGS2), M2 macrophage (VSIG4 and MS4A4A), ...
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#54Translational Research in Breast Cancer: Biomarker ...
... maturation and macrophage polarization in the tumor microenvironment. ... Udalova IA (2011) IRF5 promotes inflammatory macrophage polarization and ...
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#55Lupus ban đỏ hệ thống – Wikipedia tiếng Việt
Những gen khác có thể chứa đựng nguy cơ cho bệnh là IRF5, PTPN22, STAT4, ... Đại thực bào Tingible body (Tingible body macrophage-TBM) – loại thực bào lớn ...
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#56Identification of polarized macrophage subsets in zebrafish
Activation, morphology, and behaviour of TNF-α + macrophages in (tnfa:eGFP-F/mpeg1:mCherry-F) transgenic larvae upon wound-induced inflammation.
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#57Advances and Challenges for Understanding Macrophages in ...
Exploring the plasticity of tumor-associated macrophages (TAMs) and challenges in distinguishing M1- versus M2-polarized macrophages.
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#58Immune Rebalancing: The Future of Immunosuppression
Initiation and modulation of macrophage polarization towards M1 or M2 encompass tissue-generated ... Transcription factors IRF3 and IRF5 are also critically ...
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#59Macrophage Targeted Delivery Systems: Basic Concepts and ...
Receptors overexpressed in macrophages activin, 127 CD44 receptor, 128 GPCRs, ... 162 IL-12-loaded nanoparticles, 160 iNOS concentration, 160 IRF5/IKKβ, ...
irf5 在 コバにゃんチャンネル Youtube 的精選貼文
irf5 在 大象中醫 Youtube 的精選貼文
irf5 在 大象中醫 Youtube 的精選貼文