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#1Separase - Wikipedia
Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for ...
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#2Separase - an overview | ScienceDirect Topics
Separase orthologs exist in proliferating cells of presumably all eukaryotes. · Besides Scc1, budding yeast separase is known to cleave the Rec8 subunit of a ...
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#3Structure and function of the separase-securin complex - PMC
Separase is a large cysteine protease in eukaryotes and has crucial roles in many cellular processes, especially chromosome segregation during mitosis and ...
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#4separase - [染色分體][分]離蛋白酶 - 國家教育研究院雙語詞彙
separase. 學門: 細胞生物. 以separase 進行詞彙精確檢索結果. 出處/學術領域, 英文詞彙, 中文詞彙. 學術名詞 生命科學名詞, separase, [染色分體][分]離蛋白酶 ...
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#5Separase-triggered apoptosis enforces minimal length of mitosis
由 S Hellmuth 著作 · 2020 · 被引用 16 次 — Separase is the essential trigger protease of all eukaryotic anaphases. Once activated in metaphase, it opens the DNA-embracing cohesin ring ...
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#6Biology and insights into the role of cohesin protease ...
Separase, an enzyme that resolves sister chromatid cohesion during the metaphase-to-anaphase transition, plays a pivotal role in chromosomal ...
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#7Processing, localization, and requirement of human separase ...
In all eukaryotes, anaphase is triggered by the activation of a protease called separase. Once activated, separase cleaves a subunit of cohesin, ...
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#8Identification of Bioactive Small Molecule Inhibitors of Separase
Separase, a cysteine protease of the CD clan, triggers chromosome segregation during mitosis by cleaving the cohesin ring entrapping the two ...
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#9Cohesin Cleavage by Separase Required for Anaphase and ...
We have identified two separase cleavage sites in the human cohesin subunit SCC1 and have conditionally expressed noncleavable SCC1 mutants in human cells. Our ...
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#10Separin - Homo sapiens (Human) - ESPL1 gene & protein
Search reactions for this EC number in Rhea. ) Alternative name(s):. Caspase-like protein ESPL1. Extra spindle poles-like 1 protein. Separase.
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#11Handbook of Proteolytic Enzymes - 第 2346 頁 - Google 圖書結果
kinase 1 also enhances cleavage of Scc1 by human separase [17], but the critical phosphorylation sites in human Scc1 have not been identified yet.
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#12The Golgi Apparatus and Centriole: Functions, Interactions ...
Separase or Separin is a cysteine protease that promotes anaphase entry in mitotic cells by cleaving Ssc1, which is part of the synaptonemal complex.
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#13Separase: a universal trigger for sister chromatid disjunction ...
Separase is a protease whose liberation from its inhibitory chaperone Securin triggers sister chromatid disjunction at anaphase onset in ...
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#14Separase Is Required for Homolog and Sister Disjunction ...
Loss of cohesin or separase function results in chromosome segregation errors due to premature separation of sister chromatids or failure of ...
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#157NJ1: CryoEM structure of the human Separase-Securin ...
Separation of chromosomes during anaphase is triggered by separase-a large cysteine endopeptidase that cleaves the cohesin subunit SCC1 ...
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#16Local activation of mammalian separase in interphase ...
Separase halves eukaryotic chromosomes in M-phase by cleaving cohesin complexes holding sister chromatids together. Whether this essential protease ...
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#17Separase | Sigma-Aldrich
The universal triggering event of eukaryotic chromosome segregation is cleavage of centromeric cohesin by separase. Prior to anaphase, most separase is kept ...
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#18Conservation of the separase regulatory domain - Biology Direct
We report a protein sequence analysis of the cell cycle regulatory protease, separase. The sequence and structural conservation of the ...
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#19Separase definition and meaning | Collins English Dictionary
Example sentences. separase · After the bipolar spindle attachments on the kinetochores, the separase becomes active and cleaves the cohesion complex allowing ...
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#20Anti-Separase Antibody (B-4): sc-390314 - Santa Cruz ...
Separase Antibody (B-4) is a monoclonal anti-Separase antibody that detects human Separase by WB, IP, IF and ELISA. Cited in 1 publications.
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#21Anti-Separase antibody [XJ11-1B12] (ab16170) - Abcam
Separase antibodies can be used as a specific marker for centrosomes of mitotic cells. The staining of separase in centrosomes can be detected from prophase ...
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#22Critical Differences between Isoforms of Securin Reveal ...
Separase is responsible for cleaving the cohesin in the centromeric region, allowing sister chromatid separation at the onset of anaphase (2).
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#23Separase Monoclonal Antibody (XJ11-1B12) - Thermo Fisher
Invitrogen Anti-Separase Monoclonal (XJ11-1B12), Catalog # MA1-16595. Tested in Western Blot (WB) applications. This antibody reacts with Human samples.
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#24Detection of Separase Activity Using a Cleavage Sensor in ...
Separase proteolytically removes cohesin complexes from sister chromatid arms in meiosis I, which is essential for chromosome segregation.
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#25ANAPHASE PROMOTING COMPLEX, SEPARASE, COHESINS
ANAPHASE PROMOTING COMPLEX, SEPARASE, COHESINS. 16,334 views16K views. Jul 31, 2016. 149. Dislike. Share. Save. Walter Jahn. Walter Jahn.
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#26separase (human) - PhosphoSite
separase Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the ...
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#27Separase Antibody (NB110-85460) - Novus Biologicals
This Separase antibody is useful for Western blot, where bands are seen at ~230 kDa and ~66 kDa. The observed molecular weight of the protein may vary from ...
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#28separase - Wiktionary
NounEdit. separase (countable and uncountable, plural separases). A cysteine protease responsible for triggering anaphase by hydrolysing cohesin. Synonyms ...
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#29Separase-triggered apoptosis enforces minimal length of mitosis
Separase, a cysteine protease and trigger of all eukaryotic anaphases, has a caspase-like catalytic domain but has not previously been ...
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#30Separase - Society for Developmental Biology
Chromosome segregation in meiosis is controlled by a conserved pathway that culminates in Separase-mediated cleavage of the alpha-kleisin, Rec8, ...
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#31Arabidopsis Separase Functions beyond the Removal of ...
Abstract. Separase is a capase family protease that is required for the release of sister chromatid cohesion during meiosis and mitosis.
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#32Characterisation of cohesin and separase of Trypanosoma ...
書名：Characterisation of cohesin and separase of Trypanosoma brucei，語言：英文，ISBN：9783659500046，頁數：256，作者：Bessat Mohamed，出版日期：2014/01/08 ...
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#33Separase is Required at Multiple Pre-Anaphase Cell Cycle ...
The yeast separase proteins Esp1 and Cut1 are required for loss of sister chromatid cohesion that occurs at the moment of anaphase onset. Circumstantial ...
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#34Separase-Securin complex | SGD - Saccharomyces Genome ...
Complex formation both activates and inhibits the protease activity of separase which is responsible for cleaving the MCD1/SCC1 (Q12158) subunit of the ...
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#35Positive and Negative Regulation of Vertebrate Separase by ...
Upon entry into mitosis, Cdk1-cyclin B1-dependent phosphorylation of Ser-1126 renders separase prone to inactivation by aggregation/ ...
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#36Securin' a new role for separase | Journal of Cell Science
Separase is a protease that triggers separation of sister chromatids at mitosis by cleaving the cohesin complex that holds them together.
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#37Molecular mechanism of separase dependent PP2ACdc55 ...
The initial objective of this project was to elucidate the mechanism by which Separase promotes PP2ACdc55 inactivation at anaphase onset...
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#38Characterization of a novel separase-interacting protein and ...
Securins are key regulators of separase, an enzyme essential for chromosome segregation. However, securins are divergent in sequence and ...
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#39A mutation in separase causes genome instability and ...
cds has mitotic cells with increased size of pH3 foci and increased apoptosis and polyploidy, and is caused by a mutation in the zebrafish separase gene. (A) ...
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#40Separase cleaves the kinetochore protein Meikin to ... - bioRxiv
We demonstrate that the protease Separase rewires key cell division processes at the meiosis I/II transition by cleaving the ...
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#41Solving the separase–securin complex - - Diamond Light Source
Separase is an enzyme that is responsible for cleaving the kleisin subunits (Scc1 and Rec8) of the cohesin ring that holds sister chromatids together during ...
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#42Novel Roles of Separase in Hematopoiesis | Blood - ASH ...
Abstract. Separase, an enzyme that resolves sister chromatid cohesion during the metaphase-to-anaphase transition, plays a pivotal role in ...
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#43The Metabolism of Separase Inhibitor Sepin-1 in Human ...
Separase, a known oncogene, is widely overexpressed in numerous human tumors of breast, bone, brain, blood, and prostate.
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#44Separase (ESPL1) (NM_012291) Human Tagged ORF Clone
The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister ...
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#45pcDNA5 FRT TO myc Separase C2029A (Plasmid #59822)
Plasmid pcDNA5 FRT TO myc Separase C2029A from Dr. Stephen Taylor's lab contains the insert Separase and is published in J Cell Sci.
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#46Peptidase C50, separase (IPR005314) - InterPro entry - EMBL ...
This group of cysteine peptidases belong to MEROPS peptidase family C50 (separase family, clan CD). The active site residues for members of this family and ...
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#47New aspects of separase regulation by securin, Cdk1, PP2A ...
At the metaphase-to-anaphase transition, the protease separase is activated via the. APC/CCdc20-mediated degradation of its inhibitor proteins securin and ...
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#48ESPL1 (Separase) cleaves centromeric cohesin - Reactome
ESPL1 (separin i.e. separase) cleaves RAD21 (SCC1) subunit of centromeric cohesin at two sites that conform to the consensus separase recognition site ...
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#49Detection of Separase activity using a cleavage sensor in live ...
Separase proteolytically removes Cohesin complexes from sister chromatid arms, which is essential for chromosome segregation.
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#50Structural basis of cohesin cleavage by separase - OSTI.GOV
Separase is absolutely essential for cohesion dissolution in organisms from yeast to man. 1,2 . It cleaves the kleisin subunit of cohesin.
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#51Separase and Securin; their roles in the developing human ...
During mitosis, temporal release of separase from its inhibitor securin results in cohesin cleavage, thereby promoting anaphase. The developing fetal brain ...
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#523.4.22.49 Separase - ENZYME
Separase. Alternative Name(s). Separin. Reaction catalysed. All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in ...
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#53The Separase Project - Liang Tong Lab at Columbia University
Separase is a large (140-250 kD) eukaryotic endopeptidase belonging to the CD clan of cysteine proteases, which also includes caspases and gingipain.
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#54A closed conformation of the Caenorhabditis ... - Journals
由 G Bachmann 著作 · 被引用 10 次 — elegans separase–securin complex contrasts with the more elongated structure previously described for the Homo sapiens complex, which could ...
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#55Structural biology of the separase–securin complex ... - X-MOL
The cysteine protease separase opens the cohesin ring by cleaving its kleisin subunit and is a pivotal cell cycle factor for the transition from metaphase ...
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#56Identification and Characterization of Separase Inhibitors ...
Separase is an endopeptidase that cleaves cohesin subunit Rad21, facilitating the repair of DNA damage during interphase and the resolution ...
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#57Information on EC 3.4.22.49 - separase - BRENDA Enzyme ...
Information on EC 3.4.22.49 - separase · 3.4.22.49 · chromatid · anaphase · cohesin · sister · mitosis · securin · spindle.
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#58Regulation of cohesin cleavage by separase in Saccharomyces ...
Separase cleaves Scc1, the central subunit of the "cohesin" complex that is required for holding together the sister chromatids in metaphase. In budding yeast, ...
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#59"Role of Securin, Separase and Cohesins in female meiosis and ...
Chromosome segregation in meiosis is controlled by a conserved pathway that culminates in Separase-mediated cleavage of the α-kleisin Rec8, ...
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#60Rephrasing anaphase: separase FEARs shugoshin
Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has ...
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#61Shugoshin-PP2A counteracts Casein Kinase 1-dependent ...
Shugoshin-PP2A counteracts Casein Kinase 1-dependent cleavage of Rec8 by separase. (Tadashi Ishiguro, Koichi Tanaka, Takeshi Sakuno and Yoshinori Watanabe.
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#62教科書級的工作丨揭開分離酶在程序性細胞死亡及其活性調節新 ...
分離酶（Separase）是一種半胱氨酸蛋白酶，是所有真核細胞分裂末期過渡的觸發因子，具有類似caspase的催化結構域，但以前從未發現與細胞凋亡過程 ...
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#63Separase – A cysteine protease responsible for triggering ...
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS. Antibodies | Assay Kits | Biology Cells | cDNA | Clia ...
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#64Guillermina Valdés contó quien tomó la decisión de separase ...
Guillermina Valdés contó quien tomó la decisión de separase de Marcelo Tinelli. La reconocida modelo y empresaria rompió el silencio tras su ...
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#65Tras separase de Gerard Piqué, Shakira se mudaría a ... - Pulzo
Descripción y fotos de la casa a la que Shakira se mudaría luego de separarse de Gerard Piqué, futbolista con el que vivió en Barcelona.
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#66Solved A cell is paused in metaphase because one chromatid
Separase destroys cohesin CDC20 MAD .NO il 6. Chromatids separate, and mitosis proceeds to anaphase Separase 2. When all kinetochores are attached MAD ...
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#67Lecture 21 - The Cell Cycle Flashcards - Quizlet
What holds the sister chromatids together? · How is securin removed so that separase can degrade the cohesion protein complex? · What protein trigger DNA ...
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#68Facebook copiará a TikTok para competir con él y someterá al ...
... y haber optado por transitar otros caminos: así, años después de que Facebook se separase de su propio servicio de mensajería Messenger, ...
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#69La paternidad más allá del divorcio - Reporte Indigo
Ximena tenía dos años cuando Víctor y Ana decidieron separase, derivado de los problemas que Víctor Hugo tenía con las drogas.
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#70Tom Hanks estalla en plena calle para defender a su esposa ...
Tras separase de Lewes, el actor se casó con Wilson, con quien que ya ha celebrado 34 años de casados. En este tiempo la pareja ha tenido ...
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#71BTS anuncia su separación y se despiden con emotivo video
A pesar de que no se sabe cuándo fue que los integrantes de BTS decidieron separase, se especula que podría ser un breve break en el que ...
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#72Shakira habría sido TRAICIONADA por detectives que ...
... y aunque aún no se han revelado los verdaderos motivos que los llevó a separase, desde un principio se ha especulado que la razón fue un ...
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#73Ana Belén y Víctor Manuel, medio siglo de amor entre dos ...
... de que el rodaje se iba a acabar, de que igual no nos volveríamos a ver». Pero «al final cayó» y ya no hubo quien los separase.
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#74La tristeza, la acedia, la avaricia y la ira - Podcast - Radio Maria
... en la preocupación por conservarlas, en la dificultad que se experimenta en separase de ellas, en la pena que se siente al darlos.
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#75Ex de Britney Spears es arrestado por irrumpir en su boda
... Villalobos se gastó en sus 4 bodas con Sebastián Caicedo · Jada Pinkett y Will Smith estarían por separase y este sería multimillonario.
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#76destapan furia del entorno de Benjamín Vicuña con China ...
Aunque en un principio la idea era separase en buena, los cruces de declaraciones entre China Suárez y Benjamín Vicuña se convirtieron en ...
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#77Sara Carbonero, enamorada de nuevo: las fotos ... - MARCA
Desde que se separase de Iker Casillas, allá por el año por marzo de 2021, a Sara Carbonero no se le ha relacionado con alguien.
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#78Britney Spears y Sam Asghari: esto quedó establecido en el ...
... un acuerdo prenupcial con su actual esposo que impide que éste tenga acceso su fortuna en el caso que decidan separase en un futuro.
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#79Omar Sánchez, tajante al hablar de Anabel Pantoja - Hola
... relacionado estos últimos meses a Omar Sánchez ha sido Alexia Rivas, sobre todo desde que se separase de la sobrina de Isabel Pantoja.
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#80Ben Affleck solo tiene una frase en el documental de Jennifer ...
... y retomaron su relación casi 20 años después. El regreso se confirmó en 2021, después de que la cantante se separase de Alex Rodríguez.
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#81Xiao-Feng Zheng (@XiaoZheng3) / Twitter
News & Views: The enzymes separase and cyclin-dependent kinase are key orchestrators of cell division. Structural data reported in.
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#82Kong, las montañas que nunca existieron. - Ciencia nuestra ...
... y se comunicaba con el Congo, así que imaginó que debía existir una cordillera que separase la cuenca del Níger del golfo de Guinea.
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#83Regulation of DNA Replication - ppt download - SlidePlayer
Cohesins and Sister Chromatids. 12 Sister Chromatid Separation Securin inhibits separase Separase cleaves cohesin. Sister Chromatid Separation ...
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#84Comentarios á la Ley de enjuiciamiento civil reformada ...
... ni se propuso la declinatoria pidiendo al juez que se separase de su conocimiento , porque si bien alegó la falta de autoridad y competencia de aquel ...
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#85La jurisdicción de marina: Tratado de todas las leyes y ...
... ó se separase voluntariamente , con la guerra que le da consentencia que le impusiese el Consejo de guerra voy . ordinario , según la entidad y ...
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#86Jurisprudencia civil: colección completa de las sentencias ...
... ni se propuso la declinatoria , pidiendo al Juez que separase de su conocimiento , porque si bien alegó la falta de autoridad y competencia de aquel fué ...
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#87Colección de leyes, decretos, ordenes y demás disposiciones ...
Si el albacea se separase de su encargo , se dividirávy en proporcion al trabajo que emprendan entre él y su sucesor ó sucesores , si el segundo se separase ...
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#88Britney Spears y Sam Asghari: así es el acuerdo prenupcial ...
... un acuerdo prenupcial con su actual esposo que impide que éste tenga acceso su fortuna en el caso que decidan separase en un futuro.
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#89Franco Cabrera se luce junto a su novia Ximena en Qatar
Franco Cabrera luego de separase de Ethel fue visto con otra mujer. Tras la ruptura entre Ethel Pozo y Franco Cabrera, el actor fue visto ...
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#90Piqué molesto con Shakira y no perdona su traición - Duplos.cl
... y Gerard Piqué se opondría debido a que no quiere separase de ellos y que además, en la capital catalana tienen sus colegios y amigos.
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#91Britney Spears y Sam Asghari: los detalles del acuerdo ... - OJO
... un acuerdo prenupcial con su actual esposo que impide que éste tenga acceso su fortuna en el caso que decidan separase en un futuro.
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#92El árbol torcido - Un paso más hacia la verdad - iVoox
... y aunque su vida había sido plena no podia dejar de pensar en lo que pasaría cuando aquella máquina separase su tronco de sus raíces.
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#93El testamento oficial de Rocío Jurado: así se repartieron sus ...
... que Rocío Carrasco se separase para siempre del resto de su familia más mediática y también más cercana -por parentesco- a Rocío Jurado.
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#94LIDERAZGO EN LA CHIMENEA - Llamada de Poder
Con el paso de los días Julio comenzó a separase del equipo, de a poco dejó de participar en los eventos de la compañía y en las reuniones estratégicas que ...
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#95Herramientas Básicas de La Calidad Con Pareto y Ishikawa
agua puede separase, en otras palabras, lo que ha sucedido es una estratificacin de los materiales, este principio se utiliza en la industria manufacturera.
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