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[爆卦]STAT3是什麼？優點缺點精華區懶人包
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#1STAT3 - 維基百科，自由的百科全書
STAT3 是STAT蛋白家族的成員。受到細胞因子和生長因子的調節，STAT3被受體相關的Janus激酶（JAK）磷酸化，形成同源或異源二聚體，並轉移到細胞核，在那裡它們起轉錄激活 ...
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#2STAT3 Gene - GeneCards | STAT3 Protein | STAT3 Antibody
STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Recurrent Infection ...
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#3STAT3在肿瘤侵袭转移中的作用 - NCBI
总之，STAT3是一种可以介导多种细胞外刺激信号及酪氨酸激酶通路活性的转录因子，从而调控基因表达来影响细胞的多种重要功能。STAT3在许多生理过程中都扮演着重要的角色，如 ...
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#4An Update on the Multifaceted Roles of STAT3 in the Heart
Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and transcription factor that plays important protective ...
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#5STAT3 - Signal transducer and activator of transcription 3
Acts as a regulator of inflammatory response by regulating differentiation of naive CD4 + T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation ...
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#6STAT3 - an overview | ScienceDirect Topics
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that mediates cellular responses to a variety of cytokines and growth ...
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#7STAT3 gene: MedlinePlus Genetics
The STAT3 protein is active in tissues throughout the body. It plays an important role in the development and function of several body systems and is essential ...
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#8Approaching non-canonical STAT3 signaling to redefine ...
STAT3 is an essential cellular transcription factor that activates a cascade of survival and proliferation signaling program in cells upon cytokine and ...
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#9signal transducer and activator of transcription 3; stat3 - OMIM
The STAT3 gene encodes a transcription factor that plays a critical role in mediating cytokine-induced changes in gene expression.
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#10Revisiting STAT3 signalling in cancer: new and unexpected ...
STAT3 is mainly considered to be a direct transcription factor. Nevertheless, recent studies demonstrate that STAT3 also regulates gene ...
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#11Targeted disruption of the mouse Stat3 gene leads to early ...
These results demonstrate that Stat3 is essential for the early development of mouse embryos. Signal transducer and activator of transcription (STAT) proteins ...
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#12Stat3 as an Oncogene - Cell Press
Transient transfection of a reporter gene with Stat3 DNA-binding sites into 293T, 3Y1, NIH3T3, and HepG2 cells was used to test transcriptional activation by ...
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#13Stat3 (124H6) Mouse mAb | Cell Signaling Technology
Monoclonal Antibody for studying STAT3 in the research area. ... analysis of extracts from HeLa, NIH/3T3, PC12 and COS cells, using Stat3 (124H6) Mouse mAb.
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#14LanthaScreen™ STAT3 GripTite™ Cell Line - Thermo Fisher ...
The JAK/STAT3 signaling pathway is known to be activated by cytokines such as IL-6. In this pathway, binding of IL-6 to its cell-surface receptors results ...
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#15STAT3 Transcription Factor Assay Kit (Colorimetric) (ab207229)
STAT3 is detected by a primary antibody that recognizes an epitope of STAT3 accessible only when the protein is activated and bound to its target DNA. An HRP- ...
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#16MGI:103038 - signal transducer and activator of transcription 3
View mouse Stat3 Chr11:100777632-100830447 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression.
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#17Role of STAT3 signaling pathway in breast cancer
Signal transducer and activator of transcription 3 (STAT3) is an early tumor diagnostic marker and is known to promote breast cancer ...
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#18STAT3 Is Required for the gp130-mediated Full Activation of ...
We show that STAT3 mostly mediates the rapid activation of the c-myc gene upon stimulation of the interleukin (IL)-6 receptor or gp130, a signal transducing ...
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#19STAT3, GST-tag - BPS Bioscience
Human signal transducer and activator of transcription 3 (STAT3), GenBank Accession No. NM_139276, full length with N-terminal GST-tag, MW=120 kDa, ...
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#20Gene: STAT3 (ENSG00000168610) - Summary - Ensembl
CCDS32656, -, -, The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
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#21STAT3 Products - R&D Systems
View our 39 STAT3 products for your research including STAT3 Primary Antibodies, Small Molecules, ELISAs, Proteome Profiler Antibody Arrays, ...
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#22Stat3 inhibitor | Sigma-Aldrich
STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent ...
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#23Purified Mouse Anti-Stat3 (pY705) - BD Biosciences
The 4/P-STAT3 monoclonal antibody recognizes the phosphorylated Y705 of Stat3.
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#246TLC: Unphosphorylated human STAT3 in complex with MS3 ...
Selective inhibition of STAT3 signaling using monobodies targeting ... The transcription factor STAT3 is frequently activated in human solid ...
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#25STAT3 and its targeting inhibitors in osteosarcoma - Liu - 2021
STAT3 is considered to be an oncogene and may regulate oncogenic events involved with cell-cycle progression, apoptosis, tumour angiogenesis, ...
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#26STAT3 (human) - PhosphoSite
STAT3 Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. · Protein type: ...
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#27Tissue expression of STAT3 - Summary - The Human Protein ...
Summary of STAT3 (APRF) expression in human tissue. General cytoplasmic and nuclear expression at variable levels.
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#28Stat3 Activation by Src Induces Specific Gene Regulation and ...
Previous studies have demonstrated that one STAT family member, Stat3, possesses constitutively elevated tyrosine phosphorylation and ...
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#29Classical Canonical and Non-Canonical Pathway of STAT3 ...
STAT3 is an essential cellular transcription factor that activates a cascade of survival and proliferation signaling program in cells upon cytokine and growth ...
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#30What does Stat3 do? - The Journal of Clinical Investigation
IL-10 requires Stat3 activation for its anti-inflammatory properties on macrophages (23). How a common transcription factor activates a distinct gene program ...
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#31STAT3: A key regulator in liver fibrosis | Annals of Hepatology
STAT3 is a valued member of the JAK/STAT signaling pathway. In recent years, several studies have documented that STAT3 is closely related to the occurrence and ...
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#32STAT3 roles in viral infection: antiviral or proviral? - Future ...
Specifically, STAT3 plays a central role in the development, immunity and carcinogenesis, since it critically regulates the transcription of ...
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#33Role of STAT3 in Cancer Metastasis and Translational ...
STAT3 directly binds to the promoter of MMP2 and upregulates its expression. Additionally, STAT3 also regulate activity of MMP9 and MMP7. STAT3 regulates ...
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#34Signal transducer and activator of transcription 3 (STAT3 ...
Persistent activation of one STAT, STAT3, is a common feature of prostate cancer. Activated STAT3 was found in pathology specimens obtained from prostatectomy ...
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#35STAT3 (Signal Transducer and Activator of Transcription 3)
There are two major isoforms of STAT3. The long form is known as STAT3 (or STAT3a) and is a 770 amino acid protein (93 kDa on gels). Notable features are STAT ...
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#36Identification of novel regulators of STAT3 activity - PLOS
STAT3 is constitutively activated in many aggressive cancers where it promotes drug resistance, an inflammatory phenotype and poor clinical ...
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#37Special Issue : Advances in Biological Functions of STAT3
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in leptin-mediated regulation of energy metabolism. This study investigated ...
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#38STAT3 Selective Inhibitors | Activators - Selleck Chemicals
Catalog No Product Name Selective / Pan S8561 HJC0152 Selective S8197 APTSTAT3‑9R Selective S7923 SH5‑07 (SH‑5‑07) Selective
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#39Purified anti-STAT3 Phospho (Ser727) Antibody - BioLegend
The STAT3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is required for murine ...
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#40Strategies and Approaches of Targeting STAT3 for Cancer ...
STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed ...
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#41Somatic STAT3 Mutations in Large Granular Lymphocytic ...
STAT3 is an oncogene, and its activation plays a key role in cell signaling in many types of cancer. Since the D661V mutation was located in the ...
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#42Regulation of EMT by STAT3 in gastrointestinal cancer (Review)
STAT3 is a transcription factor aberrantly activated in most GI cancers and has both potent pro-inflammation and oncogenic properties. It is ...
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#43STAT3 signaling in ovarian cancer: a potential therapeutic target
Keywords: STAT3, ovarian cancer, tumorigenesis, inhibitors. Introduction. Signal Transducer and Activator of Transcription 3 (STAT3) is a member of STAT ...
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#44STAT3 Therapeutics | Early Stage Drug Development for ...
STAT3 Therapeutics is an early stage oncology-focused drug development company dedicated to developing and commercializing drugs that target the activated ...
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#45STAT3 Gene Set - Ma'ayan Laboratory - Computational ...
1366 target genes of the STAT3 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription ...
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#46STAT3 as a target in anti-cancer therapy | Karolinska Institutet
We are studying the mechanisms of STAT3-regulated transcription and its involvement in cancer progression and therapy resistance.
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#47Custom Gene Sequencing | STAT3 - Cincinnati Children's ...
STAT3 Gene Sequencing. Disease. Hyper-IGE Recurrent Infection Syndrome. Description. The STAT3 gene encodes the transcription factor protein, STAT3.
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#48STAT3 - My Cancer Genome
STAT3 is altered in 1.29% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal ...
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#49Stat3 Activation Is Responsible for IL-6-Dependent T Cell ...
Stat3, a member of STAT, is activated by a variety of cytokines such as IL-6 family of cytokines, granulocyte CSF, epidermal growth factor, ...
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#50STAT3: a Key Transcriptional Regulator in Cancer - Cusabio
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor. It is interesting that STAT3 was discovered because ...
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#51Expression and Activation of STAT3 in Ischemia-Induced ...
Signal transducer and activator of transcription protein-3 (STAT3) is a transcription factor that participates in many biological processes, including tumor ...
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#52Critical Roles of STAT3 in β-Adrenergic Functions in the Heart
Our data demonstrate for the first time that STAT3 has a fundamental role in βAR signaling and functions in the heart. STAT3 serves as a ...
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#53signal transducer and activator of transcription 3 - IUPHAR ...
STAT3 is a crucial component of the JAK/STAT signalling pathway that is implicated in cancer and inflammation. STAT3 is frequently activated in cancers, where ...
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#54STAT3 Antibodies - Novus Biologicals
We offer STAT3 Antibodies for use in common research applications: Chromatin Immunoprecipitation (ChIP), ELISA, Flow (Intracellular), Flow Cytometry, ...
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#55Gene expression–based discovery of atovaquone as a STAT3 ...
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that has emerged as a key cancer dependency. 2,3 STAT3 activation occurs in ...
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#56Stat3 promotes mitochondrial transcription and oxidative ...
Stat3 upregulates pivotal transcription factors in the ES cell gene regulatory network to sustain naïve identity. Stat3 also contributes to the rapid ...
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#57STAT3-brist - Socialstyrelsen
STAT3 -brist. Synonymer Jobs syndrom, Hyper IgE-syndrom, HIES, Hyperimmunoglobulin E infection syndrome. ICD-10 ...
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#58STAT3 | Cancer Genetics Web
Gene: STAT3; signal transducer and activator of transcription 3 · Aliases: APRF, HIES, ADMIO, ADMIO1 · Location: 17q21. · Summary: The protein ...
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#59STAT3 HIES mutation is a gain-of-function mutation that ...
Abstract. Cytokine or growth factor activated STAT3 undergoes multiple post-translational modifications, dimerization and translocation into nuclei, ...
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#60STAT3 - Wikiwand
信號轉導及轉錄激活蛋白3（英語：Signal transducer and activator of transcription 3，STAT3）是一種由人類基因STAT3 編碼的轉錄因子[1]。
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#61Definition of STAT3 decoy oligonucleotide - NCI Drug Dictionary
STAT3 is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck, contributing to the loss of cell growth ...
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#62STAT3 DECOY in Head and Neck Cancer - Full Text View
To estimate the effect of STAT3 decoy therapy on STAT3 activation levels, STAT3-mediated gene expression, and apoptosis in treated tumors. Condition or disease ...
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#63Nucleocytoplasmic shuttling of persistently activated STAT3
To analyze persistent STAT3 activation we coexpressed STAT3 with v-Src. We found that tyrosine phosphorylation of STAT3 by v-Src is independent ...
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#64Targeting STAT3 in hepatocellular carcinoma: Sorafenib ...
STAT3 activation requires Tyr 705 phosphorylation by different kinases such as Janus kinases, Src, EGFR, or MEK kinase 1, which results in STAT3 ...
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#65Former Blueprint vets take their new biotech out of stealth, with ...
Chief among the proteins implicated by SH2 is the STAT family, which includes the STAT3 cancer mutation long considered a holy grail target — Whiting said ...
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#66STAT3_百度百科
STAT3 是位於17號染色體的基因。 ... 中文名: STAT3; 染色體位置: 17號染色體. HGNC編號: 11364; 表達產物: Signal transducer and activator of transcription 3 ...
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#67Flavonoids and Their Disease Prevention and Treatment Potential
Tangeretin Inhibits the Stat3 Signaling Pathway and Reduces the Sox2 Level in Mammospheres To investigate the cellular mechanism by which tangeretin ...
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#69Kymera's first-in-class protein degrader shows potential to ...
STAT3 is a known target, with well-characterized roles in cancer, inflammatory disease and fibrosis. Abnormal activation of STAT3 has been ...
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#70癌症治療新想法抑制傳訊蛋白- STAT3 - 生醫新知IQ健康網
而腫瘤微環境常為缺氧狀態，容易啟動STAT3及相關的致癌因子，這時修復DNA的功能就會降低，導致致遺傳的不穩定性，助長癌症的發展。
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#71シグナル伝達兼転写活性化因子3 - 脳科学辞典
Signal transducer and activator of transcription 3 (acute-phase response factor) ... PBB GE STAT3 gnf1h01250 at tn.png.
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#72Gene Expression at the Beginning of Animal Development
In ES cells STAT3 is the predominantly expressed member , and although a minor version has been described ( STAT3b ) its function is uncertain ( Schaefer et ...
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#73Jak-Stat Signaling : From Basics to Disease - 第 97 頁 - Google 圖書結果
While it is clear that STAT3 alters the activity of the ETC and can impede mTP opening, it probably does not do so by direct binding to these complexes.
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#74Chk1 inhibition potently blocks STAT3 tyrosine705 ...
The relationship between the checkpoint kinase Chk1 and the STAT3 pathway was examined in multiple myeloma (MM) cells. Gene expression profiling ...
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#75S S D - PChome 24h購物
ADATA威剛XPG SX8200 Pro 2TB M.2 2280 PCIe SSD固態硬碟/五年保(送散熱片). ADATA威剛XPG SX8200 Pro 2TB M.2 2280 PCIe SSD固態硬碟/五年保(送散熱片).
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#76斑点鼠干货第一弹：STAT3，肿瘤研究与靶向治疗不容忽视的 ...
STAT3 最早被发现为癌基因[1]，参与调控细胞生长、分化、调亡等多种生理途径。STAT3是一个非常保守的大约由770 个氨基酸组成蛋白（小鼠和人类的STAT3 ...
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#77stat3.0数据线 - Easy海淘网
stat3.0数据线专题为您提供stat3.0数据线相关的图片、价格、品牌、评价和stat3.0数据线销量排行榜等实用导购信息，。
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#78STAT3 - 万维百科
Signal transducer and activator of transcription 3 (acute-phase response factor)信号转导及转录激活蛋白3（急性期反应因子）PDB rendering based ...
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#79糖蛋白 PTGDS 通过 MYH9 介导的 Wnt β-catenin STAT3 信号 ...
糖蛋白 PTGDS 通过 MYH9 介导的 Wnt β-catenin STAT3 信号调节促进弥漫性大 B 细胞淋巴瘤的肿瘤发生. 淋巴癌. 来源：本站原创2021-11-24 13:42.
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#80Oxford Textbook of Oncology - 第 14 頁 - Google 圖書結果
In addition, high throughput cell-based screening identified quinolines as possible inhibitors of STAT3 phosphorylation [55]. Despite intense research for ...
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#81STAT3 | JCGA
STAT3 は、STATタンパク質ファミリーのメンバーで、サイトカインおよび成長因子に反応して、受容体関連キナーゼによりリン酸化され、その後、転写活性化因子として機能 ...
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#82Preparation Technology and Pharmacology of Biological Drugs
Quinalizarin induces ROS-mediated apoptosis via MAPKs and STAT3 signaling pathways. (A) Detection of the protein expression levels of p-ERK, p-JNK, p-p38, ...
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#83DNA Tumor Viruses - 第 536 頁 - Google 圖書結果
cellular and viral proteins include CREB-binding protein (CBP), histone deacetylase-1 (HDAC1), RBP-J, MGC2663, STAT3, SWI/SNF complex, TRAP/ mediator ...
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#84Nanotechnology-COVID-19 Interface - 第 88 頁 - Google 圖書結果
Signal transducer and activator of transcription-3 (STAT3) is a key regulator of host immune and inflammatory responses. STAT3 has both proviral and ...
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#85Perspectives in Cancer Prevention-Translational Cancer Research
Cell 77: 63–71 Al Zaid Siddiquee K, Turkson J (2008) STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res 18:254–267 Arnaud ...
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#86Recludix Pharma Launches with $60 Million Series A to
Three SH2 domain inhibitor programs targeting STAT3, STAT6 and an undisclosed non-STAT target are underwayNancy Whiting, Pharm.
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#87JAK-STAT Signaling in Diseases - Google 圖書結果
Nevertheless, β cell-specific knockout of STAT3 proved to disrupt many metabolic processes. Indeed, an increase in body weight, fat mass, and fasting blood ...
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#88Cancer Genomics & Proteomics
Issue highlights. CRY1 Regulates Chemoresistance in Association With NANOG by Inhibiting Apoptosis via STAT3 Pathway in Patients With Cervical Cancer.
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#89Auto, Life Insurance, Banking, & More. Get a Free Quote ...
State Farm helps you protect what matters most with home & car insurance, checking & savings accounts, loans, and more. Get a free quote or find an ...
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#90Kymera Therapeutics to Host Virtual R&D Day on December ...
Updates on IRAKIMiD (KT-413) and STAT3 (KT-333) programs. Presentations on new pathways/programs approaching clinical development.
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#91SOS - Michigan Secretary of State
Secretary of State ALERT. Special Announcement. Secretary of State offices are open 11 a.m. to 7 p.m. on Wednesdays and 9 a.m. to 5 p.m. on other weekdays.
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#92The new State Pension - GOV.UK
How to get and claim your State Pension, State Pension age - for men born on or after 6 April 1951 and women born on or after 6 April 1953.
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#95Antonio Passaro, MD PhD on Twitter: " @CD_AACR ...
Functional STK11 mutations is associated with resistance to ICIs in #lungcancer & is reversed by STAT3 knockdown #LCSM ...
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#96PUBG: NEW STATE
PUBG: NEW STATE offers the original battle royale experience of PUBG on mobile, PUBG: NEW STATE bietet die „Battle Royale“-Erfahrung von PUBG auf ...
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#97Researchers study the link between vitamin D and inflammation
Accordingly, VitD did not induce IL-10 in cells with dysfunctional BACH2 or STAT3. Bronchoalveolar lavage fluid CD4 + T cells of COVID-19 ...
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