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#1Phosphatidylinositol 3-kinase (PI3KCA) oncogene mutation ...
由 M Kandula 著作 · 2013 · 被引用 30 次 — PIK3CA mutation is an emerging tumor marker that, in the future, might be used in the process of choosing a treatment. The detection of PI3KCA mutation ...
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#2PIK3CA gene: MedlinePlus Genetics
The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called ...
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#3PIK3CA - Phosphatidylinositol 4,5-bisphosphate 3-kinase ...
Disease descriptionA sporadically occurring, non-hereditary disorder characterized by asymmetric somatic hypertrophy and anomalies in multiple organs. It is ...
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#4Comparison of the PI3KCA pathway ... - Spandidos Publications
The phosphatidylinositol 3-kinase (PI3KCA)-AKT serine/threonine kinase (AKT) signaling pathway has been identified as one of the most important ...
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#5PIK3CA Gene - GeneCards | PK3CA Protein
PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PIK3CA ...
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#6Chronological occurrence of PI3KCA mutations ... - BMC Cancer
The frequency of women whose breast cancer liver metastases (BCLM) carries PI3KCA mutations increased from the first to the third hepatectomy.
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#7Biomarker-integrated study of single agent targeting molecular ...
Biomarker-integrated study of single agent targeting molecular alterations of PI3KCA, MET, ALK, ROS1, KRAS, NRAS or BRAF in advanced NSCLC: Phase 2 umbrella ...
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#8ANTI-PI3KCA(C-TERMINAL) antibody produced in rabbit
ANTI-PI3KCA(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution; Synonyms: Serine/threonine protein kinase PIK3CA ...
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#9Rabbit PI3KCA Polyclonal Antibody - PIK3CA - MyBioSource
PI3KCA Antibody (C-term). Product Synonym Names. Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3-kinase subunit alpha; PI3K- ...
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#10PI3KCA Antibody (Center) [102-17759] - RayBiotech
Rabbit Anti-Human PI3KCA (Center) Antibody. This PI3KCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-533 ...
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#11PI3KCA Polyclonal Antibody – Bioss
Product Name, PI3KCA Polyclonal Antibody. Applications, WB, ELISA, IHC-P, IHC-F, ... Source, KLH conjugated synthetic peptide derived from human PI3KCA.
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#12PI3KCA Peptide - 亞旭生物科技
Proteins and Peptides PI3KCA Peptide · 350481 · Brand · Description · Application · Reactivity · Photos · 歡迎填寫資料獲得亞旭第一手資訊.
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#13Phosphatidylinositol 3-kinase (PI3KCA ... - Korea Science
Phosphatidylinositol 3-kinase (PI3KCA) Oncogene Mutation Analysis and Gene Expression Profiling in Primary Breast Cancer Patients.
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#14Plasma and tumor genomic correlates of response to BYL719 ...
Of the PI3KCA mutant patients, 8 (47%) had a kinase domain mt, 7 (41%) had a helical domain mt and 1 (6%) patient had 2 PIK3CA mts. 16/17 (94%) ...
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#15Rabbit Anti-Human pI3KCA Monoclonal Antibody (Clone ...
Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3KCA) is encoded by the PIK3CA oncogene and catalyzes the ...
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#16PI3KCA Antibody (C-term) - Purified Rabbit Polyclonal Antibody ...
Western blot analysis of anti-PI3KCA Pab (Cat. #AP8016b) in HeLa cell lysate. PI3KCA (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was ...
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#17PI3KCA Antibody (BS-2067R) - Thermo Fisher
Bioss Anti-PI3KCA Polyclonal, Catalog # BS-2067R. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Frozen) (IHC (F)), ...
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#18Chronological occurrence of PI3KCA ... - Archive ouverte HAL
The aim of this study was to analyze throughout repeat hepatectomies for liver metastases the evolution of PI3KCA gene mutational status.
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#19PI3KCA Inhibition: Managing AEs in HR+ mBC - OncLive
PI3KCA Inhibition: Managing AEs in HR+ mBC · Andrew D. Seidman, MD: · Nicholas McAndrew, MD, MSCE: Certainly, Hope can speak to the very important ...
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#20BRAF and PI3KCA Mutations, their Impact on Signaling and ...
Key Words: Colorectal cancer (CRC), KRAS, BRAF, PI3KCA, mutated gene signature, microarrays, BRAF inhibitors, review. ANTICANCER RESEARCH 26: 1077-1084 (2006).
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#21A combined oncogenic pathway signature of BRAF, KRAS ...
A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction.
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#22Functional impact and targetability of PI3KCA, GNAS, and ...
Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation.
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#23Association of FGFR2 and PI3KCA genetic variants with the ...
SNPs in FGFR2 are mostly identified. However, the association between PI3KCA SNP and breast cancer risk remains largely unknown. The aim of this ...
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#24PI3KCA Polyclonal Antibody from Bioss Inc. - Biocompare
The PI3KCA Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to PIK3CA. This antibody recognizes Human, Mouse, Rat, Bovine, ...
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#25Litsea cubeba Lour, Fruits, Heartwoods, PI3KCA, Akt - Open ...
Fruits and heartwoods (CF-7F and CF-7H) in decrease expression of PI3KCA, Akt-1 and Akt-2 genes towards cervical cancer cell culture (HeLa) experiments in ...
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#26PI3KCA Antibody - Cat. No. 63-342 - ProSci Inc
IMMUNOGEN: This PI3KCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1019-1050 amino acids from the C-terminal ...
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#27PI3KCA-mutations are frequent and persist with recurrence of ...
Introduction: Some genetic mutations in breast cancer have been associated with resistance to chemotherapy, anti-Her2/Neu or anti-estrogen therapies, ...
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#28Abstract P2-09-27: Integrated analysis of PTEN protein expression ...
PI3KCA mutations (exon 9 and 20) were observed in 23.9% tumors. PI3K activation was detected in 37.5% tumors. Overall, the pCR rate was 53.5%. In low PTEN ...
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#29Summary of PI3KCA mutations and PTEN expression
Download Table | Summary of PI3KCA mutations and PTEN expression from publication: PI3K pathway activation results in low efficacy of both trastuzumab and ...
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#30Comparison of the PI3KCA pathway in circulating - ProQuest
In BC, PI3KCA mutations are frequently detected, most commonly in exon 10 (E454K and E424K) and exon 21 (H1047R), which encode the helical and kinase domain (4, ...
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#31PIK3CA／PIK3R1
Full-length human PIK3CA[1-1068(end) amino acids of accession number NP_006209.2] was co-expressed as N-terminal. DYKDDDDK tagged, biotinylated protein (128 ...
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#32MDM2 Amplification and PI3KCA Mutation in a ... - Hindawi
MDM2 Amplification and PI3KCA Mutation in a Case of Sclerosing Rhabdomyosarcoma. Ken Kikuchi , 1 George R. Wettach, 2 Christopher W. Ryan, ...
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#33Analysis of PIK3CA expression to clinicopathology features of ...
Introduction: Phosphatidylinositol 3-Kinase (PI3KCA) were signal pathways that play important roles in cell proliferation, resistance to apoptosis, ...
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#34Mechanisms of Oncogenesis: An update on Tumorigenesis
(PI3KCA). Activated FGFR3 can trigger the downstream phosphoinositide 3-kinase ... of which the catalytic p110α subunit is encoded by the PI3KCA locus [38].
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#35PI3KCA Mutations in Uterine Cervix Carcinoma - MDPI
Background: Squamous cervical carcinoma represents an infection-associated malignancy that produces a high mortality when metastatic or recurrent after ...
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#36Phosphoinositide 3-kinase - Wikipedia
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, ...
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#37Principles and Practice of Gynecologic Oncology
Similar to endometrial cancers, activation of the PI3KCA and AKT2 oncogenes occurs in some ovarian cancers. The region of chromosome 3p26 that includes the ...
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#38Intracranial venous malformation masquerading as a ... - X-MOL
Intracranial venous malformation masquerading as a meningioma in PI3KCA-related overgrowth spectrum disorder. Am. J. Med. Genet. Part A
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#39Comparison of the PI3KCA pathway in ... - EPA - HERO
Tumor tissue was investigated for PI3KCA hotspot mutations using Sanger sequencing of genomic DNA from micro‑dissected formalin‑fixed paraffin‑ ...
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#40PI3KCA Mutations in Uterine Cervix Carcinoma,Journal of ...
Background: Squamous cervical carcinoma represents an infection-associated malignancy that produces a high mortality when metastatic or ...
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#41Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ ...
Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients (IPATHER). The safety and scientific validity of ...
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#42饲料脂肪对黄颡鱼卵巢脂类代谢以及PI3KCa甲基化和转录水平 ...
Effects of dietary lipid on lipid metabolism, methylation and expression of PI3KCa in the ovary of yellow catfish (Pelteobagrus fulvidraco).
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#43Adding alpelisib to fulvestrant boosts PI3KCA-mutant ...
ESMO 2018: Patients with PI3KCA-mutant, metastatic breast cancer derive a significant PFS benefit when the PI3K inhibitor alpelisib is added ...
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#44Impact of baseline PI3KCA expression on outcomes with first ...
1484P - Impact of baseline PI3KCA expression on outcomes with first line EOX or EOX plus aspirin in advanced gastric cancer ...
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#45PI3KCA plays a major role in multiple myeloma and its ...
BYL719, a novel and specific PI3KCA inhibitor inhibited the survival of primary MM cells and cell lines but not normal peripheral blood mononuclear cells.
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#46Chronological occurrence of PI3KCA mutations ... - HAL-Inserm
Tumors carrying PI3KCA mutations are significantly larger and more frequently observed when resections were R0 compared to patients with no PI3KCA mutation.
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#47PI3K Genetic Alteration Cell Panel | ATCC
The PI3KCA status of each cell line has been sequenced and validated by ATCC. This panel is useful for PI3K pathway research and for anti-cancer drug discovery.
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#48PIK3CA基因與癌症的關係?
文章標籤. PI3K PI3KCA Cancer 癌症 大腸癌 colon cancer 基因 Gene 基因突變 Gene mutation Mutation 突變 RAS 蛋白質 細胞 ...
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#49An NRG Oncology study (NRG-GY008) - Scholars@UAB
Phase II evaluation of copanlisib, a selective inhibitor of Pi3kca, in patients with persistent or recurrent endometrial carcinoma harboring PIK3CA hotspot ...
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#50Cutaneous Epithelial Tumors Induced by Vemurafenib Involve ...
Mutation hot spots in HRAS, NRAS, KRAS, BRAF, and Pi3KCA were screened. HPV and HPyV infection status were also determined. The lesions ...
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#51Rat PI3Kca(PI3K-catalitic subunit alpha) ELISA Kit - FineTest
Product Name: Rat PI3Kca(PI3K-catalitic subunit alpha) ELISA Kit; Catalogue No. ER1910; Detection Method: Sandwich ELISA, Double Antibody ...
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#52P3.01-14 mTORC1 Regulates the Radiosensitivity of NSCLC ...
P3.01-14 mTORC1 Regulates the Radiosensitivity of NSCLC Cells with Wildtype PI3KCA and KRAS Genes by Affecting EMT. Y. Chen. Y. Chen. Affiliations.
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#53PI3KCA and PIM Inhibitors in Peripheral T-Cell Lymphomas
Abstract. Abstract 4917T-cell lymphomas (TCL) are a heterogeneous group of aggressive malignancies lacking specific and efficient therapy.
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#54Valproic Acid (VPA) in Combination with Knockdown of AKT3 ...
of AKT3 and PI3KCA Genes Inhibits Proliferation,. Induces Apoptosis and Autophagy in T98G and U87MG. Glioblastoma Multiforme Cells.
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#55PI3KCA mutation as an independent pronostic factor in anal ...
Methods: We retrospectively analyzed tumors from ASCC patients for mutational analysis of KRAS, NRAS, HRAS, BRAF, PI3KCA, MET, TP53 and FBXW7 genes. Results: ...
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#56Anti-phospho-PI3KCA (Tyr317) Polyclonal Antibodycy3 - 索莱宝
克隆类型:Polyclonal Antibody. 保存:Store at -20°C. Avoid freeze / thaw cycles. 宿主:Rabbit. 说明书下载. Anti-phospho-PI3KCA (Tyr317) Polyclonal Antibody-cy3.
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#57Molecular Pathology of Neoplastic Gastrointestinal Diseases
PI3KCA /PTEN The EGFR-receptor also activates the PI3K/AKT pathway, and two well-characterized oncogenic events in colorectal cancers include PI3KCA ...
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#58PI3KCA Antibody | Abbiotec
Accession No. P42336. Antigen. KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PI3KCA. Application ...
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#59First Radiobiological Characterization of Skin and Bone Cells ...
First Radiobiological Characterization of Skin and Bone Cells from A Patient Suffering from the PI3KCA-Related Overgrowth Spectrum (PROS) Syndrome.
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#60MDM2 amplification and PI3KCA mutation in a case of ...
Cancer gene mutation screening using a combination of multiplexed PCR and mass spectroscopy revealed a PIK3CA exon 20 H1047R mutation in the primary tumor, lung ...
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#61PI3KCA Polyclonal Antibody, Invitrogen™ 400μL - Fisher ...
PI3KCA Antibody, PA5-15246, from Invitrogen. Species Reactivity: Human; Applications: Immunohistochemistry, Western Blot. Shop PI3KCA Polyclonal Antibody, ...
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#62Methods and compositions for detecting mutations in the ...
The invention comprises reagents and methods for detecting cancer-associated mutations in the human PI3KCA (PIK3CA) gene and assessing the patients based ...
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#63PIK3CA Mutations as a Molecular Target for Hormone ...
Despite the significant achievements in the diagnosis and treatment of metastatic breast cancer (MBC), this condition remains substantially ...
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#64Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive ...
Abstract Background PIK3CA mutations occur in approximately 40% of patients with hormone receptor (HR)–positive, human epidermal growth ...
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#65Combined blockade of MEK and PI3KCA as an effective ...
MEK plus PI3KCA inhibitors treatment determined the best antitumor activity. These results were validated in vivo in HER2-amplified patient.
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#66PO-519 Combined inhibition of MEK and PI3KCA pathway ...
PO-519 Combined inhibition of MEK and PI3KCA pathway induces synergic antitumor activity in HER2 amplified colorectal cancer models ... This paper is only ...
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#67PI3KCA Antibody (F40168) - NSJ Bioreagents
This highly specific PI3KCA antibody is suitable for use in WB, IHC, ELISA and is guaranteed to work as stated on the product data sheet. | F40168.
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#68Different clinical effects upon separate inhibition of coexisting ...
Different clinical effects upon separate inhibition of coexisting EGFR and PI3KCA mutations in a lung adenocarcinoma patient. Marcello Tiseo.
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#69Taselisib Hits, but Barely Slows, PI3KCA-Mutated Breast Cancer
Taselisib Hits, but Barely Slows, PI3KCA-Mutated Breast Cancer. Nick Mulcahy. June 02, 2018. 0. CHICAGO — The investigational targeted therapy taselisib ...
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#70FDA approves first PI3K inhibitor for breast cancer
FDA approved Piqray (alpelisib) tablets, to be used in combination with the FDA-approved endocrine therapy fulvestrant.
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#71Landscape of PI3KCA mutations | Physician's Weekly
Landscape of PI3KCA mutations. Apr 1, 2021. This study states that Colorectal disease is quite possibly the most well-known malignancies in the two people.
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#72EGFR, KRAS, HER2, BRAF and PI3KCA mutation status in ...
EGFR, KRAS, HER2, BRAF and PI3KCA mutation status in metastatic cancer patients: Thoracic cytological specimens obtained in routine clinical practice · Article ...
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#73Comparison of the PI3KCA pathway in ... - Ingenta Connect
The aim of the present study was to compare the phosphatidylinositol 3-kinase (PI3KCA)-AKT serine/threonine kinase (AKT) pathway in ...
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#74PI3KCA Antibody (Center)
PI3KCA Antibody (Center) - Additional. Information. Gene ID 5290. Other Names. Phosphatidylinositol 4, 5-bisphosphate. 3-kinase catalytic subunit alpha ...
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#75Dual HER2 Blockade Less Effective in PI3KCA-Mutant Breast ...
Breast cancer patients with PI3KCA mutations are less likely to achieve a pathological complete response (pCR) from dual HER2 blockade in ...
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#76PI3KCA Could Predict Aspirin Response in Colorectal Cancer
In the VICTOR trial, patients with PI3KCA-positive colorectal cancer who took aspirin had a lower cancer recurrence compared to those with a ...
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#77Piqray New Treatment Approved for Metastatic Breast Cancer ...
In May 2019, the FDA approved Piqray (alpelisib), the first PI3K inhibitor for the treatment of metastatic breast cancer with a PI3KCA mutation in ...
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#78Mutation of the PIK3CA oncogene in human cancers - Nature
It is now well established that cancer is a genetic disease and that somatic mutations of oncogenes and tumour suppressor genes are the ...
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#79Translational Research in Breast Cancer: Biomarker ...
4.3.2.4 Activation of PI3K/AKT/mTOR Signaling Pathway This pathway can be activated via HER3 and HER2 overexpression, low PTEN expression, PI3KCA mutations, ...
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#80PIK3CA (phosphoinositide-3-kinase, catalytic, alpha ...
PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide), Authors: Montserrat Sanchez-Cespedes. Published in: Atlas Genet Cytogenet Oncol Haematol.
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#81Gastrointestinal Malignancies - 第 442 頁 - Google 圖書結果
4.12 PI3KCA and PTEN Have an Undefined Influence on Response to EGFR Therapy In addition to activating the MAPK pathway, EGFR activates the PI3-AKT pathway, ...
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#82PCR PI3KCA en tejido - Atrys Health
PCR PI3KCA en tejido. 23 de septiembre de 2021. AnteriorSiguiente. Suscríbete a nuestra newsletter. Permanece al tanto de las últimas novedades en Atrys y ...
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#84PIK3CA | My Cancer
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha - a specific mutation within the PI3 (phosphoinositide 3) kinase pathway or a gene ...
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#85DEC1 deficiency results in accelerated osteopenia through ...
The acceleration is associated with enhanced DKK1 and attenuated PI3KCA/Akt/GSK3β. •. The functionality of DEC1 is critical for both bone ...
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#86PI3Ks 在糖尿病和癌症的角色
磷酸肌醇3-激酶(Phosphatidylinositol 3-kinases，PI3Ks) 屬於一細胞內脂質激酶(lipid kinases) 家族，由細胞生物和生物化學學家Lewis Cantley 教授在1984 年發現， ...
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#87Molecular Pathology of Endocrine Diseases - 第 82 頁 - Google 圖書結果
Somatic mutations in PI3KCA, which encodes the p110a catalytic subunit of PI3K, have been identified in 7–13% of thyroid follicular carcinomas154–156 and ...
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#88Systems Biology of Cancer - 第 479 頁 - Google 圖書結果
PTEN and PI3KCA play a regulatory role in the PI3K pathway, which is one of the most highly mutated pathways in human malignancy. The PI3K pathway serves as ...
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#89Update on the Treatment of Metastatic Non-small Cell Lung ...
Alterations in the PI3KCA pathway have also been implicated in the development and progression of advanced lung cancer (14).
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#90Ciblage de la voie PI3K/AKT/ mTOR dans les cancers du sein ...
PTEN · Mutation de PI3KCA · HER2+ · mTORC1-2. L'accès au média est protégé inscrivez-vousgratuitement achetez l'article à partir de 8€ ...
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#91casino cua khau moc bai
4 天前 — ... thụ thể HER2 âm tính và bệnh nhân ung thư vú tiến triển có đột biến gen PI3KCA (HR + / HER2 - / đột biến gen PI3KCA).
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#92PERSPECTIVES
RAS, PI3KCA or AKT, or that inactivate. PTEN, are present in the majority of human cancers10. Together, this led to the hypothesis that starvation would ...
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#93PIK3CA - My Cancer Genome
PIK3CA is altered in 12.66% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung ...
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#94乳癌精準醫療對話PIK3CA基因E545K突變
基因和改變：. PIK3CA編碼p110-α，其是磷脂酰肌醇3-激酶（PI3K）的催化亞基。 PI3K途徑參與調節許多關鍵細胞功能（包括細胞生長，增殖，分化，運動性 ...
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#95Figure 1 from Gene alterations in the PI3K/PTEN/AKT pathway ...
Figure 1. The PI3K/PTEN/Akt pathway. (A) Activation of PI3K/PTEN/Akt pathway could result in increased transcription of many genes that ...
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