心肌炎的心肌細胞變化

重點：
․SARS-CoV-2直接感染 COVID-19 心肌炎患者的心肌細胞，而不會感染心臟巨噬細胞、纖維母細胞或內皮細胞。

․心肌炎的特徵是含有豐富髓樣的發炎浸潤。

․SARS-CoV-2感染心肌細胞，是通過ACE2和內體半胱氨酸蛋白酶依賴性途徑。

․hPSC 衍生的心肌細胞和工程心臟組織的感染顯示，細胞因子的產生、肌小節分解和細胞死亡是心肌細胞感染的直接後果。

․SARS-CoV-2通過肌小節分解和心肌細胞死亡降低心肌細胞收縮力。

NB: 內體半胱氨酸蛋白酶依賴性途徑：endosomal cysteine protease dependent pathway
豐富髓樣的發炎浸潤：myeloid-rich inflammatory infiltrate

Ref:
https://www.jacc.org/doi/full/10.1016/j.jacbts.2021.01.002

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Timeline Mission Endron's Dam
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