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#1Dealkylation - an overview | ScienceDirect Topics
N-Dealkylation is a frequently encountered metabolic reaction. It is often responsible for the production of the major metabolite obtained from an N-alkyl ...
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#2Dealkylation - Wikipedia
Dealkylation. From Wikipedia, the free encyclopedia. Redirect page. Jump to navigation Jump to search. Redirect to: Alkylation. Addition of alkyl group (e.g ...
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#3The molecular basis of CYP2D6-mediated N-dealkylation
由 B Bonn 著作 · 2008 · 被引用 19 次 — N-dealkylation is a commonly observed metabolic reaction for drugs containing secondary and tertiary amines. On searching the literature, it is obvious that ...
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#4Metabolic N-Dealkylation and N-Oxidation as Elucidators of ...
While both secondary and tertiary alkylamino moieties (open chain aliphatic or heterocyclic) are metabolized by CYP450 isozymes oxidative N-dealkylation, only ...
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#5dealkylation-翻译为中文-例句英语
使用Reverso Context: The metabolism is well defined and proceeds through a process of desulphurisation, dealkylation, conjugation and oxidation.， ...
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#6N-Dealkylation of an N-Cyclopropylamine by Horseradish ...
由 CL Shaffer 著作 · 2001 · 被引用 83 次 — Cyclopropylamines inactivate cytochrome P450 enzymes which catalyze their oxidative N-dealkylation. A key intermediate in both processes is ...
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#7dealkylation - 脫烷[作用] - 國家教育研究院雙語詞彙
dealkylation. 以dealkylation 進行詞彙精確檢索結果. 出處/學術領域, 英文詞彙, 中文 ...
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#8Visible light-induced oxidative N-dealkylation of alkylamines ...
N-Dealkylation of amines by metal oxo intermediates (M [[double bond, length as m-dash]] O) is related to drug detoxification and DNA repair in biological ...
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#9Oxidative degradations. (a) Exemplary O-dealkylation shown ...
(a) Exemplary O-dealkylation shown for the metabolic degradation of phenacetin by CYP1A2. The oxygen activated by the enzyme attacks next to the ether and forms ...
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#10O-Dealkylation - ACS Reagent Guide
O-dealkylation is almost exclusively employed to remove protecting groups unmasking free hydroxyl functions. Many different classes of alkyl function have ...
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#11A ubiquitin-dependent signalling axis specific for ALKBH ...
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Joshua R. Brickner,; Jennifer M. Soll, ...
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#12Dealkylation of Alkyl and Aryl Ethers with AlCl3 - NaI in the ...
A facile synthetic procedure, for dealkylation of alkyl and aryl ethers with A1C13 -Nal in the absence of solvent is developed.
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#13Selective Dealkylation of Alkyl Aryl Ethers - Zhang - 2015
Abstract Dealkylation of alkyl aryl ethers has been extensively explored. In comparison to the reported methods, selective methods that work ...
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#14Cytochrome P450 metabolic dealkylation of nine N ...
Cytochrome P450 metabolic dealkylation of nine. N-nitrosodialkylamines by human liver microsomes. Gw6naelle Bellec, Yvonne Dreano, Patrick Lozach1,.
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#15CH arylation vs. N-dealkylation of chlorinated benzamides in ...
Chemodivergence made possible by micellar photocatalysis: C-H arylation vs. N-dealkylation of chlorinated benzamides in aqueous media.
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#17Dealkylation Definition and Examples - Biology Online
The removing of alkyl groups from a compound, mainly for altering chemical reactions in organic chemistry. ... This is done by using various ...
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#18The Molecular Basis of CYP2D6-Mediated N-Dealkylation
N-Dealkylation is a commonly observed metabolic reaction for drugs containing secondary and tertiary amines. On searching the literature, ...
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#19CA2802294C - Process for n-dealkylation of tertiary amines
CA2802294C - Process for n-dealkylation of tertiary amines - Google Patents ... 238000006900 dealkylation reactions Methods 0.000 title abstract description ...
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#20Enzymatic N-, O-, and S-Dealkylation of Foreign Compounds ...
Enzymatic N-, O-, and S-Dealkylation of Foreign Compounds by Hepatic Microsomes. Authors; Authors and affiliations. Th. E. Gram.
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#21國立高雄大學應用化學系
學年度 2016 期刊等級 SCI 論文名稱(篇名) Catalysis of me<x>tal Supported Zeolites for Dealkylation-Transalkylation of Alkyl-Aro...
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#22Dealkylation | Profiles RNS
"Dealkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).
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#23dealkylation - Wiktionary
EnglishEdit. EtymologyEdit · de- + alkylation. PronunciationEdit. (UK) IPA: [diːæɫkɪˈleɪʃən]. NounEdit. dealkylation (plural dealkylations).
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#24Evidence for specific base catalysis in N-dealkylation ...
Evidence for Specific Base Catalysis in N-Dealkylation Reactions. Catalyzed by Cytochrome P450 and Chloroperoxidase.
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#25Drug Metabolism: Enzyme Mechanisms and Inhibition
Often the problem-causing biotransformation is an oxidative N-dealkylation reaction catalyzed by a cytochrome P450 enzyme. Some years ago, as a means of ...
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#26Hydrogenolytic dealkylation of alkylaromatics - OnePetro
Abstract. A series of kinetic studies has been made on hydrogenolytic thermal dealkylation of alkylaromatics including toluene, xylene isomers, ethylbenzene, a- ...
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#27Dealkylation | Harvard Catalyst Profiles
"Dealkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).
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#28Theoretical study of N-dealkylation of N-cyclopropyl-N ...
The mechanism of N-dealkylation of N-cyclopropyl-N-methylaniline (3) catalyzed by cytochrome P450. (P450) was investigated using density functional theory.
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#29Alkylaromatic hydrocarbon dealkylation process (Patent)
A process for the dealkylation of alkylaromatic hydrocarbons is described, wherein a hydrogen-rich gas stream passed through the reaction ...
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#30N-atom dealkylation of caffeine - Reactome
N-atom dealkylation of caffeine. Stable Identifier. R-HSA-76426. Type. Reaction. Species. Homo sapiens. Compartment. smooth endoplasmic reticulum.
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#31Dealkylation Meaning | Best 1 Definitions of ... - YourDictionary
What does dealkylation mean? (organic chemistry) The removal of alkyl groups from a compound. (noun)
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#32Preferential dealkylation reactions of s-triazine herbicides in ...
The preferential dealkylation pathways of the s-triazine herbicides, atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine), propazine [2-chloro-4 ...
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#33DNA dealkylation involved in DNA repair Gene Ontology Term ...
Term: DNA dealkylation involved in DNA repair. Definition: The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of ...
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#34Oxidative N-Dealkylation of Tertiary Amines with ...
[4] Additionally, dealkylation of ter- tiary amines is a fundamental reaction in the synthesis of many. N-containing compounds.[5] Being a major ...
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#35Unexpected Dealkylation During Nucleophilic Substitution
The reaction proceeds neat or in THF solution and involves dealkylation of the amine reactant by nucleophilic substitution by chloride. In the ...
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#36Computationally Assessing the Bioactivation of Drugs by N ...
In this study, we trained the model to predict N-dealkylation by human liver microsomes (HLM), finding that including isozyme-specific ...
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#37Substituted tetraphenyl porphyrin catalyzed oxidative N ...
Oxidative N-dealkylation of NN-dimethylaniline catalyzed by substituted tetraaryl porphyrin complexes of iron and manganese with molecular oxygen, ...
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#38Oxidative N-Dealkylation: A Mannich Intermediate in ... - Science
Oxidative N-Dealkylation: A Mannich Intermediate in the Formation of a New Metabolite of Lidocaine in Man. George D. Breck and William F. Trager.
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#39Analytical studies on the N-dealkylation of drug molecules by ...
In the Introduction the importance of N-dealkylation in pharmaceutical studies is summarised and the scope and potential advantages of microbial ...
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#40DNA dealkylation involved in DNA repair - Saccharomyces ...
Gene Ontology Term: DNA dealkylation involved in DNA repair. GO ID: GO:0006307; Aspect: Biological Process; Description: The repair of alkylation damage, e.g. ...
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#41Oxidative dealkylation of aromatic amines by "bare" FeO + in ...
The gas-phase reactions of FeO + with methylanilines show some similarities to the enzymatic dealkylation of amines by cytochrome P-450. The kinetic isotope ...
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#42Pygas Dealkylation (PYROTOL®) | Lummus Technology
Our dealkylation technologies (DETOL®, LITOL® and PYROTOL®) produce high purity benzene from any aromatics-rich feedstock. The yield of benzene from the ...
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#43US9067854B2 - Dealkylation process - Google Patents
Dealkylation process Download PDF ... 238000006900 dealkylation reaction Methods 0.000 title description 27; 150000001491 aromatic compounds Chemical class ...
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#44Toluene Steam Dealkylation 1974 - IHS Markit
Many dealkylation plants were built when refineries had a surplus of hydrogen from catalytic reforming, and it was assigned fuel value. Moreover, fuel values ...
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#45definition of Dealkylation by The Free Dictionary
To add one or more alkyl groups to (a compound). al′kyl·a′tion (-kə-lā′shən) n. American ...
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#46Dealkylation of Dialkyl Phosphonates with Boron Tribromide
Phosphonic acids are conveniently prepared from the cor- responding dialkyl esters by acid-catalyzed hydrolytic dealkylation, by heating them with ...
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#47Metabolic N-Dealkylation and N-Oxidation - Scholarly ...
On the other hand, tert-butyl groups are usually less prone to metabolic oxidative dealkylation (Figure 1). Intrinsic secondary N-alkylamino moieties–mostly ...
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#48dealkylation - French translation – Linguee
Sufentanil was rapidly metabolized to a large number of metabolites, with oxidative N-dealkylation at the piperidine nitrogen being the major pathway.
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#49在Chan-Lam条件下仲磺酰胺的N-脱烷基/ N-芳基化的发现
We report the discovery, scope, and limitations of a Cu‐mediated sulfonamide N‐dealkylation/N‐arylation reaction. Specific secondary N‐alkyl ...
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#50Oxidative S-Dealkylation Reaction of Sulfide Catalyzed by Co ...
In the oxygenation reaction of alkyl sulfides with Co(II)(bzacen)–O2 system, oxidative S–C bond cleavage (S-dealkylation) was found to take place ...
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#51PHARMACOKINETICS AND 0-DEALKYLATION OF ...
0-DEALKYLATION. OF MORPHINE-3-ALKYL. ETHERS. IN THE. RAT. A Radioimmunoassay ... Dealkylation is an important reaction in the biotransformation.
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#52Salen Aluminum Compounds in the Dealkylation and ...
Salen(tBu)AlBr (SAB), in the dealkylation and detection of ... Keywords: Organophosphate dealkylation, water-soluble, salen, nerve agent, ...
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#53Dealkylation and Debenzylation of Triesters of Phosphoric ...
Dealkylation and Debenzylation of Triesters of Phosphoric Acid. Phosphorylation. Hydroxy and Amino Compounds. BY LEONIDAS ZERVAS AND IRENE DILARIS.
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#54Benzene and methylbenzenes - The Essential Chemical ...
Over 50% of the methylbenzene (toluene) produced in the refinery is converted into benzene by dealkylation and disproportionation.
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#55CATALYTIC DEALKYLATION OF ALKYL AROMATIC ...
CATALYTIC DEALKYLATION OF ALKYL AROMATIC COMPOUNDS. VI.*. REACTIONS OF DIALKYLPHENOLS OVER AN ACIDIC CATAI,YST. M. KRAUS and V. BAZANT.
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#56Metabolism I - SlideShare
Oxidation of carbon- nitrogen system N- Dealkylation Oxidation of alpha- carbon atom to generate an intermediate carbinolamine ...
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#57Activation of BODIPY fluorescence by the photoinduced ...
Activation of BODIPY fluorescence by the photoinduced dealkylation of a pyridinium quencher. Sherif Shaban Ragab, Subramani Swaminathan, James D. Baker, ...
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#58fa1362ecaf371b9345c97bc34e2...
methionine bis-alkylation/dealkylation process. This method provides a straightforward and easy approach to generate cyclic peptides with ...
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#59Alkoxyquinoline O-dealkylation: A New Fluorimetric Assay for ...
The O-dealkylation of a new series of substrates, the alkoxyquinolines, provides a new easy fluorimetric assay for measuring the induction of cytochrome ...
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#60Dealkylation - Metabolic Activation - European Medical
Aromatic methyl and ethyl ethers may be metabolized to give the phenol and corresponding aldehyde (figure 4.16), as illustrated by the ...
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#61Studies on the n-dealkylation of codeine by candida tropicalis
In the general introduction, the importance of N-dealkylation in pharmaceutical studies is discussed. The scope and potential advantages of microbial ...
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#62N-dealkylation Of Barbiturates - Pharmaceutical Chemistry
224 Secondary aromatic amines may undergo N-dealkylation or N-hydroxylation to give the corresponding N-hydroxylamines. Further oxidation of the ...
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#63Cytochrome P450-catalyzed dealkylation of atrazine by ...
Cytochrome P450-catalyzed dealkylation of atrazine by Rhodococcus sp. strain NI86/21 involves hydrogen atom transfer rather than single electron transfer.
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#64adsorbed on montmorillonite K-10: An efficient catalyst for one ...
FeCl3-adsorbed on montmorillonite K-10: An efficient catalyst for one-pot dealkylation–acetylation of ethers. Show all authors. Mansour Lakouraj.
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#65A Modular and Consise Total Synthesis of (+-) - SFU's Summit
... Consise Total Synthesis of (+-)- Daurichromenic Acid and Analogues - and- A New Method for the Mild and Selective Mono-Dealkylation of Tertiary Amines.
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#66What happens in dealkylation? - Movie Cultists
What is dealkylation process? ... noun, plural: dealkylations. The removing of alkyl groups from a compound, mainly for altering chemical reactions in organic ...
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#67Lecture 6 – Drug metabolism (brief review) Phase 1 metabolism:
hydroxylation and N- or O-dealkylation. Phase 2 metabolism tends to involve conjugation. Phase 1 metabolism: A. Mono-oxygenation.
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#68(PDF) Recent advances in ether dealkylation | Daniel Zewge
Recent advances in ether dealkylation. ... Deprotection of aryl and alkyl ethers The O-dealkylation of ethers, or ether cleavage, remains an 2.1.
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#69HYDRO DEALKYLATION for TOLUENE - DWSIM
The hydrodealkylation of toluene1 (HDA) is a process used to produce BENZENE ,. METHANE and DIPHENYL . Hydrodealkylation is a chemical reaction that often ...
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#70What does dealkylation mean - Search words by mask
n. (context organic chemistry English) The removal of alkyl groups from a compound. See also: words rhyming with dealkylation, words from word ...
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#71N-dealkylation of arylpiperazine derivatives - UMF Iasi
Below article has been published as a “full text ahead of publication” on the basis of the initial materials provided by the author. Once the paper is.
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#72dealkylation - Collaborative Chemistry
Using more online software to make predictions for BIA 10-2474. Jan 19. dealkylation. by sean. This post has no tag ...
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#73Solved How does oxidative N-dealkylation of Amine - Chegg
How does oxidative N-dealkylation of Amine (N-t-buty-norchlorocylizine) occur? Note, please give details of each steps including the enzymes and products.
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#74Pyridine Compounds Source - Organic Chemistry Questions ...
b) Dealkylation of alkylpyridine ... of the following reagent can't be used as the reagent in the dealkylation of alkylpyridines in the pyridine synthesis?
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#75'Rearrangement' reactions (How Oxidative Systems ...
On the other hand, the N-dealkylation reaction of the antihistamine terfenadine has a much more dramatic effect (Figure 3.16). The oxidation of the alkyl group ...
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#76OECD Guidelines for the Testing of Chemicals, Section 3 Test ...
... (1998); Leguen et al., 2000 7-ethoxyresorufin O-dealkylation (EROD) CYP1A O-deethylation 7-Ethoxycoumarin CYP1A O-dealkylation 7-Ethoxyresorufin Nabb et ...
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#77Molecular Genetics of Drug Resistance - 第 158 頁 - Google 圖書結果
metabolized via N - dealkylation , although this is a less efficient mechanism than glutathione conjugation as removal of both N - alkyl groups is necessary ...
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#78Fortschritte der Chemie organischer Naturstoffe / Progress ...
Macdonald and co - workers have proposed that n - dealkylation of the therapeutic agent L - deprenyl effected by this enzyme ( Fig .
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#79Environmental Chemistry of Herbicides
Atrazine Hydrolysis Dealkylation OH CI CI Cyanazine Hydrolysis CH , CH , CH , CH , -H -H C ( CH ) , CONH2 C ( CH2 ) 2CO , H -C ( CH , COH -H -CH ( CH3 ) 2 ...
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#80Basic Environmental Toxicology - Google 圖書結果
O-dealkylation of ethers ROCH3→[ROCH2OH]→ROH+HCHO Propoxur, phenacetin, codeine, methoxychlor, ethoxyresorufin, pnitroanisole O-dealkylation of esters ...
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#81Environmental Chemistry - Google 圖書結果
Examples of these kinds of reactions include O-dealkylation of methoxychlor insecticides, N-dealkylation of carbaryl insecticide, and S-dealkylation.
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#82Heterogeneous Catalysis and Fine Chemicals
INTRODUCTION Steam dealkylation of aromatic hydrocarbons (SDA) is a steam reforming process in which only the alkyl group is gasified by water-eq 1.
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#83Bibliography of Scientific and Industrial Reports
Dealkylation of rhodaninos by Doans of bichronate and sulfuric acid . ( I. G. Farbenindustrie . Journal of Contral Laboratory for Dyestuffs ) ( Tranes ...
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#84Enzymes used in biocatalysis. The use of enzymes - Flight Path
Revolutionize your API syn route by using biocatalysis for the oxyfunctionalization and dealkylation of your compound in hours.
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#851 1enoouenicewaporabing di 1 [ 1 nootnemc " Suni … - ITProSpt
Question 2 Briefly describe the functions of oxygenase enzymes, including an explanation of how such systems can achieve dealkylation of amines (6) Cytochrome ...
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#86Toluene to benzene. 03 % (v/v) TMS. When the pres
... (old name: toluene) which has one of the hydrogen atoms attached to the ring replaced by a methyl group - C 6 H 5 CH 3. , dealkylation of toluene.
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#87Jigger debridement. Upon successfully completing
... Dealers Dealing Deals Dealt DEALKOXYLATION Dealkoxylated Dealkoxylating DEALKYLATION Dealkylated Dealkylating DEAMINASE … Peters' Atlas of.
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#88Friedel-Crafts Reaction - Mechanism of Alkylation and Acylation
Alkyl groups in the presence of protons or other Lewis acid are extracted in a retro-Friedel-Crafts reaction or Friedel-Crafts dealkylation.
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