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並前往https://rupress.org/jcb/article/213/6/601/38629/Untangling-Topo-II-s-function-at-mitotic

Untangling Topo II's function at mitotic centromeres

Two studies reveal a conserved, noncatalytic role for Topo II's ... they must first be untangled by the enzyme topoisomerase II (Topo II).

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