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Thermodynamics and Kinetics of Drug Binding

... NHNH H H H O O O OH O O O OH OH kon koff >1.0×10−2 s−1 t1/2 <1.2 min Kd ... 1400 min Kd 10 nM Δlog10 kon− Δlog10 koff <−0.62 Δlog10 Kd−0.43 Δlog10 ...

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