Gucci Osteria Beverly Hills has been awarded a Michelin star in the 2021 edition of the prestigious MICHELIN Guide California – a warm congratulations to the entire team, including Head Chef Mattia Agazzi, pastry chef Tamara Rigo, sous-chef Vanessa Chiu and Restaurant Director Christian Philippo. The achievement follows on the heels of Gucci Osteria’s flagship in Florence, helmed by Head Chef Karime López, receiving its first star in the 2020 MICHELIN Guide Italy.

“While it has been a very challenging time for the entire hospitality industry, the team has remained focused, united and driven to create dishes of style and substance. This Award proves that teamwork is the recipe for success!” – Mattia Agazzi

【藥事知多D】止嘔藥知多D：Aprepitant

藥罐子相信沒有多少人會喜歡服藥，更加相信沒有多少人會喜歡服化療藥。
　　
這也難怪。相較而言，化療藥的副作用實在較多、較大、較廣。

那哪一種副作用較可怕呢？
　　
首先說到化療藥，常見的副作用主要是骨髓抑制(Myelosuppression)、口腔黏膜炎(Oral Mucositis)、脫髮(Alopecia)、噁心、嘔吐(Nausea & Vomiting)、腹瀉(Diarrhoea)、不育(Infertility)等等。
　　
唔……不用問，當然是不育。
　　
還有一個，恐怕是噁心、嘔吐吧？
　　
為什麼？
　　
說到底，「不育」是化療藥的後果，而「噁心、嘔吐」則是化療藥的過程，甚至前夕……
　　
這話怎麼解？
　　
其實真正的可怕並不在這些副作用所帶來的痛苦，而在這些副作用所產生的恐懼……
　　
首先說到噁心、嘔吐，依照發生時間的長短，一般可以分為兩種，主要如下：
　　
第一，急性嘔吐(Acute Emesis)，發生在化療24小時內。
　　
第二，延遲性嘔吐(Delayed Emesis)，發生在化療24小時後。
　　
除此之外，不說不知道，跟其他副作用不同，要是一些用藥者過往在接受化療期間曾經出現噁心、嘔吐，這些經歷便可能會在用藥者的心裡蒙上一層揮之不去的陰影，在心理上，便可能會產生一種無形的恐懼，一朝被蛇咬，十年怕草繩，從而在準備接受化療前，單是看這些化療藥，連碰都不用碰，便已經開始嘔吐，稱為預期性嘔吐(Anticipatory Emesis)。
　　
簡單說，單是這種恐懼，就算不服藥，便已經能夠誘發噁心、嘔吐。
　　
你們說，可不可怕？
　　
好！要是這種化療而導致的噁心、嘔吐(Chemotherapy-induced Nausea and Vomiting, CINV)，其中一種止嘔藥便是Aprepitant。
　　
在藥理上，Aprepitant是一種NK1受體拮抗劑(NK1 Receptor Antagonist)，主要透過阻斷P物質(Substance P)來改善化療而導致的噁心、嘔吐。
　　
不過Aprepitant一般不會孤軍作戰，大多會搭配其他藥一同使用，主要是類固醇（例如Dexamethasone）、選擇性血清素再回收抑制劑(Selective Serotonin Reuptake Inhibitors, SSRIs)（例如Dolasetron、Granisetron、Ondansetron、Palonosetron），兵分三路，三路夾擊，用來預防這種化療而導致的噁心、嘔吐。

（如欲了解更多用藥資訊，歡迎看看「小小藥罐子」網誌。）

💊💊💊💊💊💊💊
BLOG➡️http://pegashadraymak.blogspot.com/
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📕📕📕📕📕📕📕
著作➡️藥事知多D、用藥知多D、藥房事件簿、家居用藥攻略（各大書店有售）

20210923 VRay For Houdini Workflow #3
模型準備注意事項 / UVs 保留進入到RBD 流程 / 基礎 substance painter 簡介！！！超棒！！！第三課！！！

▲▲ 報名規章 ▲▲

1.持有車輛保養過一次。

2.車輛必須為一手新車。

3.提供近期保養工單。

4.拍攝時間為平日上班日。

5.授權肖像於網路平台使用。

6.受訪人將給予2000元車馬費。

7.受訪人不得為汽車銷售代表或車廠相關之人員。

E-mail : rex@buycartv.com
【報名來信請填寫 1.車主姓名 2.車款與年份 3.聯絡手機號碼 4.簡短的養車經驗】


這次邀請到三位車主分別是Range Rover Evoque、Volvo XC90、Luxgen URX，他們對於自己的愛車有什麼值得分享的又或是需要抱怨的呢？讓我們來看看他們是如何說明的！

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I share my story about mental illness with Dr Farihah of HDOK , Sandakan.

I think first of all, I would like to clarify what STIGMA and DISCRIMINATION means because sometimes the two are confused with each other.

STIGMA - someone sees you in a negative way because of your mental illness
DISCRIMINATION - someone treats you in a negative way because of your mental illness

So STIGMA happens when a person defines someone by their illness rather than WHO they are as an individual. For example, they might be labelled “psychotic” rather than “a person experiencing psychosis”.

Second is to understand what is a mental illness

There are many different conditions that are recognised as mental illnesses. The more common types are:

Anxiety disorders
Mood disorders (eg Bipolar)
Psychotic disorders - hallucinations, delusions , schizophrenia
Eating disorders - Anorexia Nervosa, Bulimia Nervosa, Binge eating
Impulse Control & Addiction disorders (kleptomaniac, pyromania, compulsive gambling)
Personality disorders
OCS
PTSD

Seven Things You Can Do to Reduce Stigma

* Know the facts. Educate yourself about mental illness including substance use disorders.
* Be aware of your attitudes and behaviour. Examine your own judgmental thinking, reinforced by upbringing and society.
* Choose your words carefully. The way we speak can affect the attitudes of others.
* Educate others. Pass on facts and positive attitudes; challenge myths and stereotypes.
* Focus on the positive. Mental illness, including addictions, are only part of anyone's larger picture.
* Support people. Treat everyone with dignity and respect; offer support and encouragement.
* Include everyone. It's against the law to deny jobs or services to anyone with these health issues.

Section I Heat and Gases
1.1 Temperature, Heat and Internal Energy
Specific Heat Capacity