#禿頭有救了
#頭髮毛囊沒有萎縮只是休眠狀態
#禿髮還是有可能重生
#禿頭掉髮的現今最新研究
#台灣與哈佛團隊
#Cell國際期刊
#中醫治落髮
#心宇中醫

落髮問題是男女都會遇到的難關

雖然不會影響身體健康

但是對生活品質的影響有很大的影響

愛美與儀容對現今社會社交尤其重要

小廖醫師一直努力去保護頭頂的青絲茂密

承襲古人智慧與現今草本知識累積而研發出達特療健髮精華

門診中也常遇到幾乎沒有毛囊的患者
內心不禁懷疑頭皮毛囊幾乎萎縮還能拯救到多少呢？
近日剛好閱讀最新熱燙的禿頭研究報告
文章大意解釋是禿頭中頭髮毛囊大多是休眠狀態
只要激發它交感與豎毛肌的收縮就能改善
這是許多落髮問題的福音

這也讓小廖醫師更加確定自己的臨床想法走的方向正確💡
以下整理一下兩篇中文新聞報導可以讓想瞭解更多資訊的朋友參考
先附一下原文出處
小廖醫師先簡單整理重點內文
有想瞭解又積極學習可以點入連結中英原文哦

～～～～～～～～～～～～～～～～～
傳送門：原文出處
《Cell》Volume 182, Issue 3, 6 August 2020, Pages 578-593.e19
Article
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

YuliaShwartz ，MeryemGonzalez Celeiro，Chih-LungChen.
連結https://www.sciencedirect.com/science/article/pii/S0092867420308084#!

➡️1.中文新聞連結🔗：https://buzzorange.com/techorange/2020/08/07/found-grow-hair-secrets-from-goosebumps/

【禿頭有救了！】台大研究「雞皮疙瘩」現象，發現毛髮加速生長的秘密

台灣大學醫學工程系特聘教授林頌然領導的團隊，從「雞皮疙瘩現象」獲得啟發，發現刺激豎毛肌收縮，可提升毛囊幹細胞活性，進而加速毛髮再生，登上國際頂尖期刊「細胞」。
掉髮是很多人的困擾，也因此如何生髮，一直是科學界炙手可熱的話題。林頌然帶領的研究團隊，發現寒冷時，交感神經會高度活化，除可刺激豎毛肌收縮產生「雞皮疙瘩」外，毛囊幹細胞活性也會同時提升，具有加速毛髮再生以增進保溫的功能，這也解釋為何寒帶動物如北極熊，總是擁有著豐厚的皮毛。

毛囊具「週期性再生」現象，提升毛囊幹細胞活性可「加速毛髮再生」

林頌然解釋，冷風刺激交感神經使豎毛肌收縮及毛髮直立，可留住體表更厚的一層空氣，形成更好的冷空氣絕緣體。他們研究其中機制，發現交感神經也與毛髮生長息息相關，可提升「毛囊幹細胞」的活性，加速毛髮再生。

林頌然指出，雄性禿患者的禿髮處，也可看到豎毛肌消失，因此交感神經可能也與雄性禿的病理機轉相關。他們同時發現，交感神經在接近毛囊幹細胞處，會形成類似神經突觸的結構，使交感神經有效率地透過釋出腎上腺素，精準刺激毛囊幹細胞的活性。而毛囊幹細胞是透過 ADRB2 受體接受訊號，進而啟動毛囊再生。

➡️2.加強深入原文之中文翻譯原文報導連結🔗：Cell丨頭髮去哪裡了？交感神經或能告訴你答案。原文網址：https://71a.xyz/oJyDae

2020年7月16日，來自美國哈佛大學的Ya-Chieh Hsu研究團隊在Cell上發表題為「Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells」的文章，首次發現豎毛肌(arrector pili muscle，APM，間質細胞)對HFSC(毛囊幹細胞,hair follicle stem cell ) 的交感神經支配的形成和維持至關重要,發現APM可促使交感神經支配通過傳遞神經遞質去甲腎上腺素的突觸樣連接來直接激活HFSC，從而調控著毛囊的再生。揭示了上皮細胞、間質細胞和神經細胞三種類型相整合，從而使組織在發育、體內平衡和對環境刺激的反應中維持和發揮功能的機制。

希望大家可以幫吓可仁啦😢 我希望個個小朋友都可以健康快樂咁成長，可以一齊去公園玩

【最新消息：募捐行動已於2018年12月3日結束】中大校友慈善基金感謝各界慷慨支持，募捐行動已結束。所得善款將支持張可仁及患上相類疾病需免疫治療的其他6位病童。

詳情請參閱中大校友慈善基金網頁：https://www.facebook.com/cuhkacf.org/posts/589827338133781

-------------------------------------------------------------------------------------
(2018/11/22)

中大醫學院向大家作出緊急呼籲，支持我們2000年的醫科畢業生張俊傑醫生，拯救他只有17個月大的兒子張可仁的性命。

可仁早於出生第4天時已被診斷罹患一種罕有心臟病「主動脈狹窄」(Coarctation of Aorta)，需要接受緊急手術。極之不幸的是，可仁最近再被確診患上「第四期神經母腫瘤」(Stage IV Neuroblastoma)，目前可仁的頭骨至腰椎和盆骨均受到癌細胞擴散，脊髓神經線受到癌細胞壓住，痛楚非常，並有癱瘓的危機，癌細胞更正轉移至骨髓。

可仁現時正住在威爾斯親王醫院兒童癌症中心隔離病房，極容易受到感染。他已開始接受化療，而治療方案將包括化療、手術、放射治療、骨髓移植、免疫治療，治療時間約一年至一年半。他完成化療、手術和放射治療後，會進行骨髓移植，之後需要免疫療法，這可大大提高存活率，由20%升至50%。

然而，免疫治療需要病人自費，所需費用高達港幣200萬元。張醫生另一兒子患有自閉症，太太辭掉小學主任一職，全職照顧兩位小朋友，並要照顧父母親，經濟上未能承擔高昂的醫療費用。

中大醫學院2000年畢業同學會發起是次籌款，目的包括：
1. 為可仁進行骨髓移植後的免疫治療；
2. 引發社會人士及政府對兒童罕有癌症治療的關注。

查詢：
香港中文大學校友慈善基金
電郵：info@cuhkacf.org
電話：2180 4316

-------------------------------------------------------------------------------------

【Fundraising Campaign Completed on 3 December 2018】According to CUHK Alumni Charity Foundation, the fundraising campaign for Mark CHEUNG Ho Yan has completed. The fund raised will be used to support the immunotherapy of Mark and 6 other patients who are suffered from the same disease. Thank you for all your kind-hearted support and generosity.

-------------------------------------------------------------------------------------

(2018/11/22)

This is an urgent appeal for your generosity to save the life of the 17-month-old son of Dr. CHEUNG Chun Kit, our medical alumnus of Class 2000.

Dr. Cheung Chun Kit is a CUHK medical graduate of Year 2000. His younger son, Cheung Ho Yan Mark, has recently been diagnosed to have Stage IV Neuroblastoma in November 2018, and is in an emergency need of donation to provide the necessary funding to support the life-saving yet expensive immunotherapy.

Mark was presented to his paediatrician for fever and cough in late October 2018. His cough resolved with treatment but his fever never completely went away. Two days prior to his diagnosis, Mark was more clingy than usual and did not like to walk. On a video clip, Mark was noted to have foot drop, a very significant red flag which may indicate a compression on the spinal cord. Emergency scans were immediately performed that night, and Mark was found to have a large tumour on the left side of his abdomen. The aggressive tumour had already spread silently to the back of his skull, his spine, his hips and had compressed his nerves which control his lower limbs, resulting in pain on standing and difficulty in walking. Mark is facing an imminent risk of paralysis.

Mark is diagnosed to have a rare childhood cancer which is called Stage IV neuroblastoma, a cancer which typically presents at late stage because it arises deep in the abdomen. To cure his aggressive cancer, Mark needs to survive through rounds of intensive chemotherapy, radiotherapy, surgery, bone marrow transplant, and finally, immunotherapy. The whole treatment duration lasts 1.5 to 2 years. To completely eradicate all cancer cells, immunotherapy will be needed to boost Mark’s survival from 20% to 50%. However, immunotherapy is a self-financed treatment in the public hospital and the treatment costs could be up to 2 million.

Such close encounter with death is not the first time for Mark. At the first week of life, Mark was diagnosed to have a rare heart problem called “Coarctation of Aorta”. Mark had received life-saving surgery to reestablish the blood flow across his aorta, the major blood vessel that allows blood to go from the heart to the brain and the rest of the body. In a report published in 2002, only 67 cases with dual heart condition and neuroblastoma were reported, giving an odd of 1 in 100 million for a child to be hit by these two rare diseases. Scientists have not yet completely understood the mechanisms that may cause the two conditions to appear in a single child.

It never rains but pours that Mark’s elder brother, now 5 years old, was diagnosed to have autism at around age 2. To enable the elder brother to have intensive training to improve his outcome and development, Mark’s mommy quit her job as a primary school teacher since the diagnosis of autism was made for his elder brother. Dr. Cheung, who is a medical doctor for the elderly, became the sole bread-winner of his family.

CUHK Medical Graduates of Year 2000 have initiated a fund-raising campaign for Mark and his family with the following two objectives:

1. To appeal for donation to support the costs of immunotherapy for Mark
2. To increase the public awareness on the grave needs of children with cancers

Enquiries:
CUHK Alumni Charity Foundation Limited
Email: info@cuhkacf.org
Telephone: 2180 4316

🙏🏻🙏🏻🙏🏻

【最新消息：募捐行動已於2018年12月3日結束】中大校友慈善基金感謝各界慷慨支持，募捐行動已結束。所得善款將支持張可仁及患上相類疾病需免疫治療的其他6位病童。

詳情請參閱中大校友慈善基金網頁：https://www.facebook.com/cuhkacf.org/posts/589827338133781

-------------------------------------------------------------------------------------
(2018/11/22)

中大醫學院向大家作出緊急呼籲，支持我們2000年的醫科畢業生張俊傑醫生，拯救他只有17個月大的兒子張可仁的性命。

可仁早於出生第4天時已被診斷罹患一種罕有心臟病「主動脈狹窄」(Coarctation of Aorta)，需要接受緊急手術。極之不幸的是，可仁最近再被確診患上「第四期神經母腫瘤」(Stage IV Neuroblastoma)，目前可仁的頭骨至腰椎和盆骨均受到癌細胞擴散，脊髓神經線受到癌細胞壓住，痛楚非常，並有癱瘓的危機，癌細胞更正轉移至骨髓。

可仁現時正住在威爾斯親王醫院兒童癌症中心隔離病房，極容易受到感染。他已開始接受化療，而治療方案將包括化療、手術、放射治療、骨髓移植、免疫治療，治療時間約一年至一年半。他完成化療、手術和放射治療後，會進行骨髓移植，之後需要免疫療法，這可大大提高存活率，由20%升至50%。

然而，免疫治療需要病人自費，所需費用高達港幣200萬元。張醫生另一兒子患有自閉症，太太辭掉小學主任一職，全職照顧兩位小朋友，並要照顧父母親，經濟上未能承擔高昂的醫療費用。

中大醫學院2000年畢業同學會發起是次籌款，目的包括：
1. 為可仁進行骨髓移植後的免疫治療；
2. 引發社會人士及政府對兒童罕有癌症治療的關注。

查詢：
香港中文大學校友慈善基金
電郵：info@cuhkacf.org
電話：2180 4316

-------------------------------------------------------------------------------------

【Fundraising Campaign Completed on 3 December 2018】According to CUHK Alumni Charity Foundation, the fundraising campaign for Mark CHEUNG Ho Yan has completed. The fund raised will be used to support the immunotherapy of Mark and 6 other patients who are suffered from the same disease. Thank you for all your kind-hearted support and generosity.

-------------------------------------------------------------------------------------

(2018/11/22)

This is an urgent appeal for your generosity to save the life of the 17-month-old son of Dr. CHEUNG Chun Kit, our medical alumnus of Class 2000.

Dr. Cheung Chun Kit is a CUHK medical graduate of Year 2000. His younger son, Cheung Ho Yan Mark, has recently been diagnosed to have Stage IV Neuroblastoma in November 2018, and is in an emergency need of donation to provide the necessary funding to support the life-saving yet expensive immunotherapy.

Mark was presented to his paediatrician for fever and cough in late October 2018. His cough resolved with treatment but his fever never completely went away. Two days prior to his diagnosis, Mark was more clingy than usual and did not like to walk. On a video clip, Mark was noted to have foot drop, a very significant red flag which may indicate a compression on the spinal cord. Emergency scans were immediately performed that night, and Mark was found to have a large tumour on the left side of his abdomen. The aggressive tumour had already spread silently to the back of his skull, his spine, his hips and had compressed his nerves which control his lower limbs, resulting in pain on standing and difficulty in walking. Mark is facing an imminent risk of paralysis.

Mark is diagnosed to have a rare childhood cancer which is called Stage IV neuroblastoma, a cancer which typically presents at late stage because it arises deep in the abdomen. To cure his aggressive cancer, Mark needs to survive through rounds of intensive chemotherapy, radiotherapy, surgery, bone marrow transplant, and finally, immunotherapy. The whole treatment duration lasts 1.5 to 2 years. To completely eradicate all cancer cells, immunotherapy will be needed to boost Mark’s survival from 20% to 50%. However, immunotherapy is a self-financed treatment in the public hospital and the treatment costs could be up to 2 million.

Such close encounter with death is not the first time for Mark. At the first week of life, Mark was diagnosed to have a rare heart problem called “Coarctation of Aorta”. Mark had received life-saving surgery to reestablish the blood flow across his aorta, the major blood vessel that allows blood to go from the heart to the brain and the rest of the body. In a report published in 2002, only 67 cases with dual heart condition and neuroblastoma were reported, giving an odd of 1 in 100 million for a child to be hit by these two rare diseases. Scientists have not yet completely understood the mechanisms that may cause the two conditions to appear in a single child.

It never rains but pours that Mark’s elder brother, now 5 years old, was diagnosed to have autism at around age 2. To enable the elder brother to have intensive training to improve his outcome and development, Mark’s mommy quit her job as a primary school teacher since the diagnosis of autism was made for his elder brother. Dr. Cheung, who is a medical doctor for the elderly, became the sole bread-winner of his family.

CUHK Medical Graduates of Year 2000 have initiated a fund-raising campaign for Mark and his family with the following two objectives:

1. To appeal for donation to support the costs of immunotherapy for Mark
2. To increase the public awareness on the grave needs of children with cancers

Enquiries:
CUHK Alumni Charity Foundation Limited
Email: info@cuhkacf.org
Telephone: 2180 4316