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#1ERK1/2 MAP kinases: structure, function, and regulation
由 R Roskoski Jr 著作 · 2012 · 被引用 1512 次 — ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this ...
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#2Extracellular signal-regulated kinases - Wikipedia
Activation of the ERK1/2 pathway by aberrant RAS/RAF signalling, DNA damage, and oxidative stress leads to cellular senescence.
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#3The ERK1/2 mitogen-activated protein kinase pathway as a ...
The ERK1/2 MAP kinase pathway has emerged as a central regulator of cell proliferation by controlling both cell growth and cell cycle ...
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#4Mechanisms shaping the role of ERK1/2 in cellular ...
As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in ...
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#5ERK1/2: A Key Cellular Component for the Formation ...
由 JH Medina 著作 · 2018 · 被引用 32 次 — Extracellular regulated kinase 1/2 (ERK1/2; also known as p42/p44 MAPK) are highly conserved protein kinases linking several transmembrane ...
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#6ERK1/2 MAP kinases in cell survival and apoptosis
Summary. ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and.
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#7ERK1/2 Antibody (14-9108-82) - Thermo Fisher
Invitrogen Anti-ERK1/2 Monoclonal (5AD13MA), eBioscience™, Catalog # 14-9108-82. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and ...
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#8Inhibition of ERK1/2 Signaling Pathway is Involved in ...
Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells.
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#9ERK1/2 phosphorylation is an independent predictor of ...
ERK1 /2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia ... Blood (2007) 109 (12): 5473– ...
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#10ERK1/2 signaling in cancer - Abcam
ERK1 /2-signaling in cancer · The Ras-Raf-MEK-ERK/MAPK pathway is highly conserved in metazoans and controls many of the principal pathways involved in cell ...
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#11Erk1/2 Phosphorylation and Reactive Oxygen Species ...
The increased level of phosphorylated Erk1/2 led to an extensive increase in ROS formation. By use of NO synthase inhibitors, we found that intracellular ...
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#12Comprehensive Analysis of ERK1/2 Substrates for Potential ...
The RAS-RAF-MEK1/2-ERK1/2 pathway remains one of the most commonly dysregulated pathways in human cancers, based on which several inhibitors ...
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#13p44/42 MAPK (Erk1/2) Antibody#9102 - Cell Signaling ...
The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and ...
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#14ERK1/2 antibody (16443-1-AP) | Proteintech
ERK1 and ERK2 belongs to the protein kinase superfamily. It is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in ...
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#15ERK1/2 activation is a therapeutic target in age-related ...
Alu RNA overexpression or DICER1 knockdown increases ERK1/2 phosphorylation in the RPE in mice and in human cell culture. Alu RNA-induced RPE degeneration ...
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#16Mitogen-activated protein (MAP) kinase, ERK1/2 (IPR008349)
Mitogen-activated protein (MAP) kinase, ERK1/2 ... Short name: MAPK_ERK1/2 ... ERK1 (also known as MAPK3) and ERK2 (also known as MAPK1) are proteins of 43 ...
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#17Negative feedback regulation of the ERK1/2 MAPK pathway
The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signalling pathway regulates many cellular ...
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#18ERK1/2 Research Products - Novus Biologicals
The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called p44 and p42 MAP kinases, are members of the Mitogen Activated Protein Kinase ...
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#19Selective ERK1/2 agonists isolated from Melia azedarach with ...
We provided evidence that A1541–43 and Cedrelone specifically target ERK1/2, but not the upstream MAPK/ERK pathway. Computational docking ...
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#20Activation of Extracellular Signal–Regulated Kinases (ERK1/2 ...
Among the signal events likely to be important in Ang II–mediated effects is activation of ERK1/2. ERK1 and ERK2 are serine/threonine protein kinases activated ...
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#21Chemo-resistance in Gastrointestinal Cancers
Hence, we inspected the level of some Bcl-2 family members following GCDA (which can activate ERK1/2 pathway) or PD98059 (which can repress ERK1/2 pathway) ...
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#22MAPK3 Gene - Mitogen-Activated Protein Kinase 3 - GeneCards
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 ...
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#23Radiation-Induced c-Jun Activation Depends on MEK1-ERK1 ...
Overall, our study reveals that the MEK-ERK1/2 signaling pathway, but not the JNK pathway, contributes to the c-Jun-dependent microglial ...
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#24Erk1/2 MAP kinases are required for epidermal G2/M ...
Erk1 /2 mitogen-activated protein kinases (MAPKs) are often hyperactivated in human cancers, where they affect multiple processes, ...
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#25ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke
To compare ERK1/2 activation and inhibition side-by-side, we also used mice with ubiquitous overexpression of the Raf-kinase inhibitor protein ( ...
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#26ERK1/2 mitogen-activated protein kinase selectively mediates ...
ERK1 /2 activation also occurred in mice with null mutations of STAT6. Systemic administration of the MAPK/ERK kinase 1 (MEK1) inhibitor PD98059 or use of Tg ...
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#27Activation of the ERK1/2 Signaling Pathway Promotes ...
We have previously shown that the ERK1/2 pathway acts independently of PI3K to block expression of the BH3-only protein, BimEL, and prevent ...
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#28ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates ...
ERK1 /2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties. Severine Stamboulian, Jin-Sung ...
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#29ERK subfamily | Enzymes - IUPHAR/BPS Guide to ...
... MAP kinase 3 | MAP kinase isoform p44 | MAPK 1 | MAPK 3 | microtubule-associated protein 2 kinase | MNK1 | p44-ERK1 | p44 MAP kinase | Mtap2k | PRKM3.
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#30Extracellular Signal Regulated Kinases 1/2 p (ERK1/2) - 博客來
書名：Extracellular Signal Regulated Kinases 1/2 p (ERK1/2)，語言：英文，ISBN：9786138913085，頁數：148，作者：Shehab Ahmed, Salam Shehab Ahmed,Saleh Hasan, ...
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#31Erk1/2- and p38 MAP kinase-dependent phosphorylation and ...
This study examined the upstream signaling pathways initiated by muscarinic m2 and m3 receptors that mediate sustained ERK1/2- and p38 MAP kinase-dependent ...
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#32Sustained Activation of Akt and Erk1/2 Is Required for Coxiella ...
Sustained prosurvival signaling by Akt and Erk1/2 contributes to decreased host cell apoptosis during C. burnetii infection as specific ...
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#33Neuronal mechanisms of epileptogenesis - 第 57 頁 - Google 圖書結果
We have evaluated a second marker of neuronal cell activity by characterizing p-ERK1/2-immunopositive cells. ERK is member of the mammalian ...
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#34phospho-ERK1 (pThr202/pTyr204) and ERK2 (pThr185 ...
Mitogen-activated protein kinase (MAPK) superfamily of enzymes is involved in widespread signalling pathways. Members of this family include the ERK1/2 ( ...
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#35ERK1/2_百度百科
中文名. 細胞外調節蛋白激酶 · 外文名. extracellular regulated protein kinases · 統稱. ERK1/2 · 縮寫. ERK.
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#36Modulation of ERK1/2 Levels by Enantiomers of Formoterol in ...
RATIONALE: Beta-2 adrenoreceptor agonists can modulate proliferation and release of cytokines by human airway smooth muscle cells (HASMC).
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#37A First-in-Human Phase I Study to Evaluate the ERK1/2 ...
Signaling through the MAPK pathway has been associated with malignant transformation in a variety of cancers. We developed an ERK1/2 inhibitor as a novel ...
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#38Issues in Ophthalmology and Optometry Research and Practice: ...
Investigators publish new data in the report 'ERK1/2 signaling pathways involved in VEGF release in diabetic rat retina.' “Vascular endothelial growth ...
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#39Receptor Tyrosine Kinases: Family and Subfamilies
Although stimulation of KIT has been shown to activate ERK1/2, p38, JNK, and ERK5, most studies have been focusing on the mechanisms of activation of ERK1/2 ...
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#40NiemannPick type C2 protein regulates liver cancer ...
Epub 2015 Mar 24. NiemannPick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and.
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#41二肽基肽酶4通过ERK1/2信号通路促进人血管平滑肌细胞钙化
DPP4干预15 min明显刺激ERK1/2的磷酸化(P<0.05)，ERK1/2抑制剂可明显降低DPP4刺激的相关钙化蛋白表达(P<0.05)。
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#42Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 ...
Giulia Treccani · Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine.
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#43Oxytocin reduces anxiety via ERK1/2 activation: Local effect ...
Oxytocin reduces anxiety via ERK1/2 activation: Local effect within the rat hypothalamic paraventricular nucleus. Citation. Blume, A., Bosch, O. J., Miklos, ...
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#44Glioma Signaling - 第 54 頁 - Google 圖書結果
The PTX-sensitive mechanism, in which Gi protein was involved, led to cell proliferation via activation of both the ERK1/2 and PI3K/Akt kinase signaling.
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#45IL-17A activates ERK1/2 and enhances differentiation of ...
IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells. Jane M. Rodgers, Andrew P. Robinson, ...
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#46Signal Transduction in Cancer Metastasis - 第 32 頁 - Google 圖書結果
constitutive and inducible expression of MHC class II proteins is regulated by the ... Studies have shown that ERK1/2 signaling negatively regulates the ...
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#47ERK1/ERK2 (Phospho) [pT202/pY204]/[pT185/pY187 ...
2-8℃. Protein name, ERK1/2. 物种（Tested）. 人. 试剂盒类型. InstantOne ELISA. 检测抗体偶联物. Biotin. 标记（染料）. HRP. Gene ID, (Human) 5595, (Human) 5594.
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#48Engineering Adult Neurogenesis and Gliogenesis
We further investigated key determinants oligodendrogenesis and found that the application of DMSO FIGURE 4 | DMSO blocks phosphorylation of Erk1/2.
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#49MAPK/ERK Signaling Pathway - YouTube
How to Speak. MIT OpenCourseWare. MIT OpenCourseWare. •. 8.1M views 2 years ago · Signal Transduction Pathways (G-Protein, Receptor Tyrosine ...
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#50Melusin and IQGAP1 are key players in ERK1/2 signaling and ...
Guido Tarone, Molecular Biotechnology Center, University of Turin, Turin - ITALY, speaks on "Melusin and IQGAP1 are key players in ERK1 / 2 ...
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#51Macrocyclic lactones inhibit nasopharyngeal carcinoma cells ...
(B) Quantifications of phosphorylated RAF1 and ERK1/2 protein expression in CNE-1 cells were done as 3 independent experiments. IVM treatment at ...
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#52Di(2-ethylhexyl) Phthalate Induces Apoptosis Through ...
The role of PPAR-gamma (PPAR-γ), class B scavenger receptor type 1 (SR-B1), and ERK1/2 was further studied to examine the signaling pathway ...
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#53Figures and data in Polo-like kinase 1 induces epithelial-to ...
ERK1 /2 activation is essential for PLK1-induced EMT and increased motility of prostate epithelial cells. (A) The effect of PLK1 overexpression ...
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#54MAPK1 (ERK2) activation - Reactome
22177953, MEK1/2 dual-specificity protein kinases: structure and regulation. Roskoski, R Jr. Biochem. Biophys. Res. Commun. 2012.
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#55科技部通报54起医院科研不端案例
十九、吉林大学中日联谊医院魏鑫为通讯作者、范李为第一作者的论文“Carcinogenic role of K-Ras-ERK1/2 signaling in bladder cancer via inhibition of ...
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#56ERK経路：バイオキーワード集｜実験医学online
WETラボのためのGitHub活用術〜NGS解析を通して学ぶ（実験医学2022年2月号連載のご紹介）. 1/16. Info. Shopping. Tap to unmute. If playback doesn't begin shortly, ...
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#57gcp antivirus. Log in to the Google Cloud console.To activate ...
Phase 2/3 clinical trial of S-217622 is currently underway in mild or ... Western blot analysis for c-Jun, phosphorylated-ERK1/2 (Thr202/Tyr204) (p-ERK1/2), ...
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#58TPL-2–ERK1/2 Signaling Promotes Host Resistance against ...
The TPL-2–ERK1/2 signaling pathway regulated production by macrophages of several cytokines important in the immune response to M. tuberculosis ...
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#59Outstanding questions in developmental ERK signaling
In this case, two ventrolateral stripes of the epidermal growth ... Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs.
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#60Ras-Raf-MAPK SOS1 SHC Grb2 Ras Raf1 MEK1 MEK2 ERK1 ...
Activation of ERK1/2 via MEK1/2 is a critical step in growth factor signaling, ... growth factor receptor-bound protein 2; SRF, serum response factor.
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#61关于'冀州【微信812828338】哪里能玩到小妹特殊服务哪里 ...
一、比选项目序号产品名称规格、型号数量预购单价（元）备注1NF-κB Pathway Sampler Kit1Kit(7x20µl)25950 科研使用，购买一次科研使用，购买一次2Phospho-Erk1/2 ...
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#62Identification of potent HDAC 2 inhibitors using E ... - Paperity
However, HDAC 2 overexpression triggers cell proliferation by diverse mechanisms in cancer. Over the decades, many pan and class-specific inhibitors of HDAC ...
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#63Ilk semi The enduring finish guards timber against harsh ...
Well, semi-skimmed or 2 percent is ideal in most circumstances, because it's ... conferring ERK1/2/NF-κB-mediated growth advantages to gastric cancer cells.
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#64ERK1 and ERK2 mitogen-activated protein kinases affect Ras ...
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. Journal of Biology 5 (5) , 14.
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#65org/doctors/1154571313/colleen-elaine-tobe- ://healthcare. is ...
(2) Elaine Coker (married December 31, 1973-present) Tony LaRussa ... Reed Elaine F HLA class I-mediated stress fiber formation requires ERK1/2 activation ...
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#6612dpt beta I had my HCG levels checked on both 10dpt (10 ...
In general, hCG-beta numbers double every 2 to 3 days in around 85% of healthy ... of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages Feb 09, ...
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#67How to mix hcg 5000 iu for 23 days Hope that helps - Uczymy ...
Jan 01, 2022 · Just 500 IU of HCG every 2 days is enough to counteract the ... pathway and p38 as well as ERK1/2 pathways in human placenta [28], [43].
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#68Généalogie : recherchez vos ancêtres, publiez votre ...
Généalogie : Comment retrouver vos ancêtres et créer votre arbre généalogique sur Geneanet ?
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#69It Tastes so Good, however Is It Poisoning Your Beloved Ones?
Mia, for instance, had undergone two miscarriages however when ... cells by means of non-genomic estrogen receptor/ERK1/2 signaling pathway.
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#70AJILE12: Long-term naturalistic human intracranial neural ...
An antibody typically consists of two immunoglobulin heavy. ... We noted that suppression of p70S6K/S6, but not ERK1/2, was associated with ...
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#71Marktanalyse für Erk1-Antikörper, Forschungsstudie ...
Der Global Erk1-Antikörper-Marktbericht bietet Einblicke in folgende ... Kapitel 2 Globale wirtschaftliche Auswirkungen auf die Industrie.