COVID-19 的兒科急診日記

今天開始降二級。

提醒大家：

1.大家仍然要勤洗手、戴好口罩、保持社交距離、不要群聚！

2.若你尚未施打疫苗，請你務必注意個人防護措施。

3.若你已施打完成疫苗者，請你就需要預防突破性感染。

我們仍要持續監測 COVID-19 突破性感染的風險。

今天來談「疫苗中和抗體效價比較 」！

全世界正對目前流行COVID-19的變種病毒株造成疫苗保護力可能下降而擔憂中。

美國紐約大學格羅斯曼醫學院的研究人員2021 年7 月 19日上傳到預印本BioRxiv 的一篇研究論文⋯⋯

「mRNA疫苗 和腺病毒載體疫苗對抗 COVID-19變種病毒株引發的中和抗體效價比較」

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants

論文中，研究人員說明mRNA疫苗和腺病毒載體的疫苗產生的抗體，對 Beta、Delta、Delta plus 和 Lambda 變種病毒株等的中和能力的變化情形。

研究人員從參與研究個體在接種疫苗後一周至三個月的幾個時間點收集血清。此外，還評估了個體生成的抗體對幾種變種病毒株的中和活性。

重點如下:

1.BNT疫苗 和 Moderna疫苗引發的抗體對 Beta、Delta、Delta plus 和 Lambda 變種顯示出「適度」的中和抗體效價。

2.而來自大部分接種腺病毒載體疫苗(Janssen疫苗) 的個體引發的抗體具有「低」中和效價（IC 50 <50）。

3. 腺病毒載體疫苗(Janssen疫苗)與 mRNA 疫苗相比，從接種腺病毒載體疫苗的個體收集的血清被認為針對相關變種病毒的效力下降更大， 例如研究顯示Janssen疫苗針對 delta plus 或 beta 變體的效力與針對D614G 相比，效力下降了約 5-7 倍。

4.大家需注意COVID-19變種病毒株對恢復期或疫苗誘導的抗體表現出「一定程度的抵抗力」。

5.研究也說明接種 mRNA 疫苗後三個月仍可能對任何譜系變種病毒株產生足夠的反應。

最後此研究強調需要持續監測 COVID-19 突破性感染的重要性，並說明在接種腺病毒載體疫苗(Janssen疫苗)之後，可能需考慮進行第二次免疫接種以增加對抗COVID-19變種病毒株的重要。

聯亞疫苗擠身全球10個受關注的高潛能二代疫苗選手！

4月29日，Clinical Trials Arena （臨床試驗論壇——一個為高階專業人士提供全球臨床試驗市場相關新聞、觀點和趨勢的平台）發表一篇名為「10個下一代新冠肺炎疫苗選手 」（10 next-gen Covid-19 vaccines in the race for approval）的分析，聯亞研發中的疫苗，擠身受關注的這十大高潛能疫苗之一！
二代疫苗因為第一代疫苗的副作用連連，而備受期待！
報告內容中說：

與武漢肺炎的戰爭仍然在持續中，雖然目前一線藥廠已紛紛推出有效疫苗，但無論AZ、嬌生、BNT，在世界各地都有傳出副作用，例如血栓或是心肌炎等。世界因此轉向注意那些研發速度較慢，但製作方法比較不一樣的疫苗。

本文列出10個WHO登記有案的疫苗，已進入最後階段的高潛能疫苗供參。
～～～
Vaxxinity (聯亞)
Candidate name: UB-612

這支疫苗能同時活化Ｔ細胞跟Ｂ細胞，強化全面免疫能力。在台灣進行的實驗收取第一期60人，第二期3850人。

一期研究表明 UB-612 的安全性、耐受性和免疫原性的評估結果，發現該疫苗通常具有良好的耐受性，並引發了強烈的疫苗誘導的 CD4+/CD8+ T 細胞抗體反應。

Vaxxinity 也已和醫療公司 Dasa 合作在巴西進行 II/III 期試驗，並與內布拉斯加大學合作在美國進行 I/II 期試驗。
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以上是內容摘要。
全世界還有一百多個疫苗在研發，能夠被關注，視為十個臨床試驗中的高潛能選手之一，表示是一個值得期待的二代疫苗。雖然結果還在未定之天，但是至少我們不必妄自菲薄！
台灣的反對黨在國產疫苗的政策鬥爭中，詆毀國產疫苗的公信力，和國際產業科學形容國產疫苗的高潛能，形成了諷刺的對比！
台灣需要發展疫苗產業，不只如此，醫藥生技產業急起直追，從中國鎖藥危機中，取回我們的「醫藥主權」、「疫苗主權」，已經是國安戰略的問題。
根據「今周刊」的報導，除了
B N T疫苗，中資取得台灣授權的藥物，包括抗生素、癌症用藥等，高達130種之多。這問題呈現的非常清楚，中國正利用商業手段，促成「醫統」，企圖用鎖藥、鎖疫苗， 逼我們就範、引我們內亂；這次讓我們買不到BNT疫苗，赤裸裸的演習了一次，政府被逼得束手無策，最後美、日出手相助，過程的紛亂，餘悸猶存！
今天提供這個資料，是希望大家拉出一個全球比較的視野，平等的看待國產疫苗。

Mechanism: Multitope peptide-based vaccine

Trial phase: Phase II/III

Vaxxinity (formerly COVAXX), a subsidiary of United Biomedical (UBI), is developing UB-612, a multitope protein/synthetic peptide-based vaccine candidate for Covid-19. UB-612 is designed to activate both T-cell and B-cell immunity in the body and has shown neutralising antibody activity in mice, rats, and guinea pigs.

In Taiwan, a Phase I trial of up to 60 participants is underway, and a Phase II trial of 3,850 participants has been initiated.

Results from the Phase I study, which evaluated the safety, tolerability, and immunogenicity of UB-612, showed that the vaccine was generally well-tolerated and elicited robust vaccine-induced CD4+/CD8+ T cell antibody responses.

Vaxxinity is also partnering with medical company Dasa for a Phase II/III trial in Brazil, and with the University of Nebraska for Phase I/II trials in the United States.

https://www.clinicaltrialsarena.com/analysis/10-next-gen-covid-19-vaccines-in-the-race-for-approval/?fbclid=IwAR1EMGP5RBoJ0oX_KCMhgAVLG-hV2sVQDN4SAaGK80beBqAjJR_mX-4RxBU

Tiếp nối ‘Vùng Mơ’, một vùng không gian khác tựa đề "Vùng Yên" đang được vẽ nên bởi Hứa Vĩ Văn ngay tại không gian của 188 Võ Thị Sáu.

Với cùng một cảm thức, được khơi gợi và thôi thúc bởi cái đẹp tự nhiên và lòng trắc ẩn, chúng tôi cùng Hứa Vĩ Văn mở ra một nơi chốn có thật trong thế giới xúc cảm của người nghệ sĩ, từ đó đặt để vào đúng không gian nơi những những sự sẻ chia cần được lan tỏa. Ý nghĩa của tác phẩm lần này nhiều hơn là một đề tựa, và vươn ra xa khỏi bốn khung bo vật lý.

Để tìm hiểu xem câu chuyện đó là gì, mời bạn đón đợi cùng chúng tôi vào ngày 08.05 này!
_____

Following ‘Dreamland’, another land titled "Night Irene" (meaning "Peace" in Greek) by Hua Vi Van is in the making right in the workplace at 188 Vo Thi Sau.

With the same mind that is elicited and inspired by the natural beauty and compassion, together, we and Hua Vi Van open up actual space in the artist's heart and mind, and from there spread the sharing into the right place. The meaning of the artwork is more than a mere title, extending far beyond the four physical frames.

Stay tuned and find out the full story behind the artwork on this May 8th!

#Toong #coworking #WorkmeetsArt #goclab #goccreation #artresidency #artinworkplace #officespace #workplace #huavivan #hcmc

Hope you all love this video!

Only Allen Iverson could deliver a Hall of Fame speech that name-checked '90s rappers, referenced "Chappelle's Show" and thanked just about every person he met along his basketball journey. Only Shaquille O'Neal could follow that act with what amounted to a half-hour comedy routine that needled former coaches and teammates and included a soap-opera shout-out.

The Naismith Memorial Basketball Hall of Fame's Class of 2016 lived up to its lofty billing with an epic three-hour induction ceremony Friday night at Springfield's Symphony Hall, with Iverson and O'Neal stealing the show.

Iverson delivered a captivating 31-minute speech in which he overcame initial jitters during a memorable address that featured multiple standing ovations. Fans with No. 3 Iverson jerseys in the balcony cheered throughout.

Dressed in a black suit with a black shirt and tie, Iverson paused repeatedly to collect himself at the start of his speech while thanking his three presenters -- Larry Brown, Julius Erving and John Thompson -- as well as members of his family.

Fighting tears throughout, Iverson thanked former Georgetown coach Thompson "for saving my life."

"[After] the incident happened in high school and all that was taken away ... no other schools would recruit me anymore," Iverson recalled, referencing a racial brawl at a bowling alley that landed him in jail. His conviction in the case was later overturned. "My mom went to Georgetown and begged [Thompson] to give me a chance. And he did."

He said he later left Georgetown only as "an OK basketball player."

"But once I started to listen to Larry Brown and take constructive criticism, I learned how much of a great, great coach that he really is. ... That's when I became an MVP," Iverson said.

In maybe the most memorable moment of his address, Iverson recalled his first time playing against his idol, Michael Jordan.

"Man, I wanted to be like Mike," Iverson said. "I remember the first time I played against him. I walked out on the court and I looked at him. And, for the first time in my life, a human being didn't really look real to me. You know what I mean? I don't know if you all watch the 'Chappelle Show,' but he talked about a certain incident where somebody's seeing Rick James. Like I literally seen his aura. It looked like he was glowing.

"I'm sitting there, and I'm saying, 'Man, that's Michael.' And I'm looking at him. I can't stop looking at him. I'm looking at his shoes, and I'm like, man, he's got on the Jordans! It was my Mike. It was my idol, my hero."

After the Jordan story, Iverson seemed to settle in. Nervously rocking at the start of his speech, he confidently thanked a Rolodex of coaches, owners, teammates and rappers.

"I want to thank Biggie Smalls, Redman, Jadakiss, Tupac and Michael Jackson for being my theme music throughout my career," Iverson said.

Twenty-two minutes into his speech, Iverson said, "The Philly fans," and that elicited a monster reaction from the balcony, which immediately engaged in an "MVP" chant.

Added Iverson: "My relationship with the fans in Philadelphia is like no other. I thank you all for the support over the years. ... You never jumped off the bandwagon, continued to support me like true fans are supposed to."

Iverson also paid tribute to "the ones that stuck by me throughout my journey." He cited "all the barbershop talk that my family had and all the arguments my friends had with people in the barbershop and hair salon.

"Now you can say: 'Well, look, my man is solidified.'"

Iverson closed his speech with a nod to the "guys who are not my friends anymore."

"I'm glad that you blew your cover for me to recognize that you [weren't] any good to my family or me. And I appreciate y'all for that. So if I make any more new friends, I know the signs," he said.

Not to be outdone, O'Neal took the stage for a punchline-filled speech as the final inductee of the night.

O'Neal referenced Luke and Laura from "General Hospital" and joked about his commercial endeavors, including how he sat in a "Buick I knew I couldn't fit in." Drawing laughter, O'Neal added, "Hey, they paid me $3 million. What did you want me to say, no?"

His speech had serious moments, like when he thanked his parents, Phil Harrison and Lucille O'Neal, for giving him the discipline and drive that drove his NBA dream.

"If I know my father, he's up there arguing with Wilt [Chamberlain] that his son is the best big man in the game," O'Neal said.