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#1ABCG1 has a critical role in mediating cholesterol efflux to ...
由 MA Kennedy 著作 · 2005 · 被引用 915 次 — Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of ...
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#2The cholesterol transporter ABCG1 links cholesterol ... - Nature
ABCG1 effluxes excess cholesterol from cells to high-density lipoprotein (HDL) particles for reverse cholesterol transport, which is the only ...
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#3Article ABCG1 has a critical role in mediating cholesterol efflux ...
From the histological data it is clear that ABCG1 is required to maintain proper lipid homeostasis in macrophages and hepatocytes. Given that ABCG1 was both ...
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#4Role of HDL, ABCA1, and ABCG1 ... - AHA Journals
The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of macrophage cholesterol efflux to serum or HDL in ...
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#5Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol ...
Cholesterol efflux by ABCG1 is mediated via reorganization of cholesterol in the plasma membrane, which increases plasma membrane cholesterol ...
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#6The cholesterol transporter ABCG1 modulates macrophage ...
The ATP-binding Cassette Transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis.
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#7Effects of acceptor composition and mechanism of ABCG1 ...
Abstract Among the known mechanisms of reverse choles- terol transport (RCT), ATP binding cassette transporter G1. (ABCG1)-mediated free cholesterol (FC) ...
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#8RAGE Suppresses ABCG1-Mediated Macrophage ...
Diabetes exacerbates cardiovascular disease, at least in part through suppression of macrophage cholesterol efflux and levels of the ...
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#9The Human ABCG1 Transporter Mobilizes Plasma Membrane ...
In the present study, we examined ABCG1-induced changes in membrane cholesterol distribution, organization, and mobility. ABCG1-GFP expression increased the ...
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#10Cellular Cholesterol Regulates Ubiquitination and ...
Using CHO cell lines stably expressing human ABCA1 or ABCG1, we observed that the abundance of these proteins is increased by cell cholesterol loading. The ...
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#11ABCG1 (ABC8), the human homolog of the Drosophila white ...
Cholesterol efflux mediated by high-density lipoproteins (HDL) constitutes a protective mechanism against macrophage lipid overloading. The molecular mechanisms ...
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#12SR-BI associates with ABCG1 and inhibits ABCG1-mediated ...
The single and combined effects of scavenger receptor-BI (SR-BI), ATP-binding cassette transporter (ABC) A1 and G1 on cholesterol efflux ...
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#13Significance of Cholesterol-Binding Motifs in ABCA1, ABCG1 ...
ABCA1, ABCG1 transporters, and SR-B1 receptor are the major proteins involved in cholesterol efflux from cells. We superposed in silico the ...
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#14Function of ABCA1 and ABCG1 in Cholesterol Homeostasis
ATP-binding cassette protein A1 (ABCA1) and ABCG1 play important roles in cholesterol homeostasis by removing excess cholesterol from peripheral tissues ...
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#15Macrophage ABCA1 and ABCG1, but not SR-BI, promote ... - JCI
Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux ...
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#16Associations of ABCG1-mediated cholesterol efflux capacity ...
Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy.
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#17Lack of Abcg1 results in decreased plasma HDL cholesterol ...
Liver lipid composition was not affected by the absence of Abcg1. Biliary cholesterol secretion was 47% higher in Abcg1−/− mice on HCD (p < ...
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#18搜索
Astragalin retards atherosclerosis by promoting cholesterol efflux and ... via up-regulating ABCA1 and ABCG1 expression in macrophages.
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#19Role of ABCG1 and ABCA1 in Regulation of Neuronal ... - DOI
ApoE discs potently accelerated cholesterol efflux from primary human neurons and cell lines. The process was saturable (17.5 μg of apoE/ml) and was not ...
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#20Cholesterol Transporters ABCA1 and ABCG1 Gene ... - Hindawi
ABCA1 and ABCG1 genes encode the cholesterol transporter proteins that play a key role in cholesterol and phospholipids homeostasis.
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#21Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent ...
ABCA1- and ABCG1-mediated cholesterol efflux to apolipoprotein A-Ⅰ (apoA-Ⅰ) and HDL, respectively, were measured by green fluorescent ...
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#22Leonurine Prevents Atherosclerosis Via Promoting the ...
Conclusions: Leonurine can promote cholesterol efflux and alleviate ... of ABCA1 or ABCG1 expression decreases cellular cholesterol efflux ...
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#23Phosphorylation by protein kinase C stabilizes ABCG1 and ...
PKC activation by TPA increased ABCG1 protein levels and promoted ABCG1-dependent cholesterol efflux to HDL. This activity was suppressed by ...
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#24Effect of apoA-I Mutations in the Capacity of Reconstituted ...
To address this, we measured cholesterol efflux from HEK293 cells or J774 mouse macrophages overexpressing ABCG1 using as acceptors ...
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#25搜索
Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy.
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#26Downregulation of ABCA1 and ABCG1 transporters by ...
The role of statins in CCA cell cholesterol transport through the expression and function of ATP‑binding cassette (ABC) A1 and ABCG1 was ...
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#27LXR Agonists and ABCG1-dependent Cholesterol Efflux in ...
LXR Agonists and ABCG1-dependent Cholesterol Efflux in MCF-7 Breast Cancer Cells: Relation to Proliferation and Apoptosis. ALI EL ROZ, JEAN-MARIE BARD, JEAN- ...
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#28Extracellular lipid-free apolipoprotein E inhibits HCV ... - Gut
LF-apoE induces ATP-binding cassette subfamily G member 1 (ABCG1) protein-dependent cholesterol efflux that inhibits HCV replication. LF-apoE increases ...
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#29Role of HDL, ABCA1, and ABCG1 ... - ResearchGate
Request PDF | Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses | Atherosclerosis has been characterized as a chronic ...
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#30ATP‐binding cassette transporters and cholesterol translocation
ABCG1 mediates cellular cholesterol export to lipidated lipoprotein particles (6, 10-12). This review focuses on ...
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#31Extra-virgin olive oil consumption improves the capacity of ...
EVOO consumption also increased the release of excess cholesterol from human monocyte-derived macrophages (HMDM) by 44 % (P< 0·001), and ABCA1 and ABCG1 mRNA ...
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#32Structure of the Human Cholesterol Transporter ABCG1
ABCG1 is an ATP binding cassette (ABC) transporter that removes excess cholesterol from peripheral tissues. Despite its role in preventing lipid ...
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#33Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors ...
This rHDL also promoted ABCG1, but not SR-BI, cholesterol efflux. All large and lipid-rich rHDLs, with a diameter of ≥9.6 nm and a ...
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#34ABCG1-mediated transport of intracellular cholesterol to the ...
In an ATP-dependent reaction, ABCG1 mediates the movement of intracellular cholesterol to the extracellular face of the plasma membrane.
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#35Control of insulin granule formation and function by the ABC ...
Cholesterol regulatory proteins ABCG1, ABCA1, and OSBP regulate the production, packaging, and export of insulin by pancreatic b-cells and ...
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#36ABCG1 has a critical role in mediating ... - Europe PMC
In contrast, overexpression of human ABCG1 protects murine tissues from dietary fat-induced lipid accumulation. Finally, we show that cholesterol efflux to ...
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#37ABCG1 - Wikipedia
This protein is a member of the White subfamily. It is involved in macrophage, cholesterol and phospholipids transport, and may regulate cellular lipid ...
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#38abstract - ASM Journals
ABCG1 may also play a role in cholesterol efflux, though its role is not well ... Apart from effects on cholesterol flux, apoE overexpression in mice has ...
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#397R8D: The structure of human ABCG1 E242Q with cholesterol
Molecular basis of cholesterol efflux via ABCG subfamily transporters. · Entity ID: 1 · UniProt & NIH Common Fund Data Resources · Protein Feature ...
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#40Triglyceride Up-regulates Expression of ABCG1 in PMA ...
Also, TG induced phosphorylation of JNK and p38 MAPK in THP-1 macrophages. These results suggest that TG may potentially influence cholesterol ...
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#41Role of the ABC transporters ABCA1 and ABCG1 in foam cell ...
Enhancing reverse cholesterol transport from macrophages in the arterial wall tothe liver for biliary excretion has been identified as a ...
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#42Dysregulation of cholesterol homeostasis in human lung ...
Moreover, depletion of the cholesterol efflux transporter ATP-binding cassette transporter G1 (ABCG1) inhibited tumour growth through the ...
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#43ATP-Binding Cassette Transporters G1 and G4 Mediate ... - jstor
transfected 293 cells, ABCG1 and ABCG4 stimulate cholesterol efflux to both smaller (HDL-3) and larger (HDL-2) subclasses but not to lipid-poor.apoA-1.
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#44AGE-BSA decreases ABCG1 expression and reduces ...
Isoda, Kikuo, Eduardo J. Folco, Koichi Shimizu, and Peter Libby. 2007. “AGE-BSA Decreases ABCG1 Expression and Reduces Macrophage Cholesterol Efflux to HDL.
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#452型糖尿病患者单核巨噬细胞胆固醇外流的降低与ABCG1表达 ...
Objective To identify potential linkage of cholesterol efflux with the expressions of ATP-binding cassette receptor A1 (ABCA1), ABCG1 and ...
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#47High-Density Lipoproteins: Structure, Metabolism, Function ...
Does ABCG1 play a major quantitative role in cholesterol efflux to HDL from human macrophages? The role of the ABCG1-mediated pathway of cholesterol efflux ...
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#48Lipid Transfer in Lipoprotein Metabolism and Cardiovascular ...
Thus, it has been proposed that ABCG1 at the plasma membrane mobilizes plasma membrane cholesterol and ABCG1 in late endosomes and lysosomes generates ...
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#49Cholesterol: New Insights for the Healthcare Professional: ...
Researchers detail in 'Stimulation of cholesterol efflux by LXR agonists in cholesterolloaded human macrophages is ABCA1-dependent but ABCG1-independent,' ...
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#50Dancing with the sterols: critical roles for ABCG1, ABCA1 ...
The physiological roles of ABC transporters including ABCA1, ABCG1,ABCG5, and ABCG8 are discussed, and how they mediate cholesterol efflux ...
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#51Relevance of Steroid Biosynthesis, Metabolism and Transport ...
Alternatively, cholesterol can exit the STB via ABCA1 and ABCG1, which stimulate efflux of cholesterol and oxysterols (Aye et al., 2009).
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#52Endothelium and Cardiovascular Diseases: Vascular Biology ...
a transporter similar to ABCG1 that mediates cholesterol efflux in megakaryocyte precursor cells, controls platelet production and thrombosis [38].
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#53Abc Transporters Of Human Physiology And Disease, The: ...
Since exogenously added SM reduced cholesterol efflux, a decrease in the SM ... Alternatively, ABCG1 may co-transport cholesterol with SM as substrates for ...
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#54Targeting Lipid Rafts as a Strategy against Infection and Cancer
Excess cholesterol is exported to the blood by ATP-binding cassette subfamily A member 1 (ABCA1) or the subfamily G member 1 (ABCG1). Cholesterol can also ...
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#55Regulation of direct transintestinal cholesterol excretion in mice
Biliary secretion is generally considered to be an obligate step in the pathway of excess cholesterol excretion from the body. We have recently shown that ...
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#56ABCG1 has a critical role in mediating cholesterol ... - CORE
These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis. Introduction.
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#57The Metabolic Effects of Obesity and Bariatric Surgery
... diabetic retinopathy, corneal confocal microscopy, ABCG1, vitamin d, bone, ... Bariatric Surgery, Obesity, cholesterol efflux capacity ...
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