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#1YCT529 - Wikipedia
YCT529 is a drug which acts as a potent and selective antagonist of the Vitamin A receptor retinoic acid receptor alpha (RAR-α). In studies on mice it ...
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#2A non-hormonal pill could soon expand men's birth control ...
A non-hormonal male contraceptive (known as YCT529; structure shown here) prevents pregnancy in mice by blocking a vitamin A receptor, with no ...
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#3男避孕藥即將面世？避孕效果達99%無副作用 - Yahoo新聞
實驗中，雄性老鼠口服YCT529 約4週後，老鼠的精子數量顯著減少，而且避孕效果高達99%，老鼠身上也沒有任何副作用。當老鼠停服YCT529 後4至6星期，它們 ...
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#4男性口服避孕藥動物實驗99%有效「無變胖副作用」最快五年上市
研究團隊研發一複合物YCT529，能特定阻斷醛視紫酸與另一扮演細胞增殖及肧胎發育要角的「視黃酸受體α（RAR-alpha）」兩者作用，以達到避孕效果。
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#5The Science Behind The New Male Contraceptive Pill ...
Scientists have now reported that a compound, named YCT529, may act as an effective non-hormonal male contraceptive. When given to male mice orally, YCT529 had ...
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#6YCT529 - Ligands - IUPHAR/BPS Guide to PHARMACOLOGY
Comment: YCT529 is an oral retinoic acid receptor alpha (RAR-α) antagonist, that is being investigated as a non-hormonal male contraceptive.
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#7YCT529 | RAR-α Inhibitor - MedChemExpress
YCT529 is a potent, selective and orally active RAR-α inhibitor. · RAR-α · When given orally to male mice for 4 weeks, YCT529 dramatically reduces sperm counts ...
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#8'The world is ready for a male contraceptive' | MinnPost
MP: How does YCT529 work? GG: Our non-hormonal method is similar to what a hormonal contraceptive does. It reduces sperm count. We reduce sperm ...
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#9How close are we to getting a male contraceptive?
Georg's team was able to license YCT529 to an San Francisco-based biotech YourChoice Therapeutics. The biotech recently raised $15 million ...
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#10Birth Control Pill for Men Expected to Begin Clinical Trial in 2022
When given orally to male mice for 4 weeks, YCT529 dramatically reduced sperm counts and was 99% effective in preventing pregnancy, without any observable side ...
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#11Male Birth Control Options: Which One Is Right for You?
What it is: YCT529 is another chemical that's being developed as a non-hormonal male birth control pill. It's thought to reduce sperm counts by ...
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#12Emerging concepts in male contraception: a narrative review ...
YCT529 is an α-selective retinoic acid antagonist recently presented at the American Chemical Society national meeting 2022.
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#13New non-hormonal contraceptive pill for men?
Oral administration of YCT529 reduced sperm count, preventing pregnancy. One month after administration of the compound was stopped, the mice ...
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#14SLO3 in the fast lane: The latest male contraceptive target with ...
... of potential drugs emerged, such as EP055 against EPPIN (1), CDD-1102 against BRDT (2), triptonide against JUP/SPEM1 (3), and YCT529 against RARA (4).
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#15File:YCT529 structure.png - Wikimedia Commons
File:YCT529 structure.png ... English: Structure of YCT529 ... {{Information |Description={{en|Structure of YCT529}} |Source={{Own}} ...
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#16男避孕藥即將面世？避孕效果達99%無副作用| 8杯水Meditorial.co
當老鼠停服YCT529 後4至6星期，它們再次恢復生育能力，而Noman的指導教授Gunda Georg 博士指，YCT529在2022年下半年開始人體臨床實驗，希望非荷爾蒙男性 ...
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#17YCT529 - Wikidata
YCT529. chemical compound ... YCT529 structure.png 1,445 × 841; 52 KB. 0 references ... 0 references. Commons category. YCT529. 0 references ...
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#18A non-hormonal pill could soon expand men's b - EurekAlert!
When given orally to male mice for 4 weeks, YCT529 dramatically reduced sperm counts and was 99% effective in preventing pregnancy, without any ...
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#19Verhütungsmethoden für Männer: YCT529 verhüte! - taz.de
Verhütungsmethoden für Männer: YCT529 verhüte! Seit Jahrzehnten scheitern Forscher*innen an der Pille für den Mann.
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#20Male Contraceptive Pill Found 99% Effective in Preventing ...
Recently, scientists developed YCT529 drastically reduced sperm count, was 99% effective in preventing pregnancy in mice and didn't cause observable side ...
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#21New Male Birth Control Pill Works in Study - MedicineNet
When given orally to male mice for four weeks, YCT529 significantly reduced sperm counts and was 99% effective in preventing pregnancy, without causing any ...
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#22Researchers Begin Human Trial to Develop Male Birth Control
The YCT529 compound was given orally to male mice for 4 weeks, which reduced sperm counts and was 99% effective in preventing pregnancy, ...
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#23What's the Latest on Men's Birth Control Options? - Healthnews
One non-hormonal option under investigation is a compound called YCT529, which inhibits retinoic acid receptor alpha (RAR-α) — a protein associated with ...
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#24Despite Encouraging Research, a Male Birth Control Pill ...
Researchers gave this compound, referred to as YCT529, to male mice for four weeks; the animals showed drastically lower sperm counts.
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#25A male birth control pill? U of M study is entering new phase
They call it YCT529. And from a science point of view, this is an inhibitor of a protein called retinoic acid receptor alpha.
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#26Education | Male contraceptive pill - Candor
RAR-α binds to a form of Vitamin A that affects how sperm develop. A recent study showed mice taking YCT529 became infertile. After a month the contraception ...
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#27Is that an oral male contraceptive on the horizon?
YCT529 was given to mice orally for 4 weeks and the researchers reported a greatly reduced sperm count that was 99% effective in preventing ...
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#28YCT529 - Wikiwand
YCT529 is a drug which acts as a potent and selective antagonist of the Vitamin A receptor retinoic acid receptor alpha . In studies on mice it produced a ...
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#29UGA College of Pharmacy Chu Lectureship to Feature ...
The lecture, titled “The Male Pill: Are We There Yet?,” will focus on the discovery and development of the non-hormonal male contraceptive agent YCT529, ...
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#30Male contraceptive pill - trials in mice prevent 99% of ...
The team's drug, named YCT529, shuts off a protein called the retinoic acid receptor alpha (RAR-α) that binds to vitamin A and plays an ...
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#31Scientists develop male contraceptive pill March 24, 202266 ...
did RAR-β and -γ. “When given orally to male mice for 4 weeks, YCT529 dramatically reduced sperm counts and was 99% effective in preventing pregnancy, without ...
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#32Abstract_Georg_Michigan_2022.docx
In collaboration with the Wolgemuth group at Columbia University we have discovered the non-hormonal male contraceptive agent YCT529 that is targeting ...
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#33New Male Contraceptive Reduces Sperm Count by 45% in Mice
In 2022, the laboratory of Professor Gunda Georg at the University of Minnesota developed a drug – YCT529 – that prevents pregnancy in mice ...
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#34WARF Therapeutics Distinguished Lecture in Drug Discovery
In collaboration with the Wolgemuth group at Columbia University we have discovered the non-hormonal male contraceptive agent YCT529 that is ...
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#35New approaches to male contraception
When given orally to male mice for four weeks, the lead compound, YCT529, dramatically reduced sperm counts and was 99% effective in ...
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#36A New Male Birth Control Pill Works — in Mice - UCI Health
When given orally to male mice for four weeks, YCT529 significantly reduced sperm counts and was 99% effective in preventing pregnancy, without causing any ...
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#37Male Contraceptive Pill Found 99% Effective in Mice, With No ...
When administered orally to male mice for four weeks, YCT529 drastically reduced sperm counts and was 99 percent effective in preventing ...
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#38New Male Birth Control Pill Effectively Prevents Pregnancy
Researchers have developed a non-hormonal male contraceptive, YCT529, which effectively and reversibly prevents conception in mice without side ...
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#39YCT529: un promettente contraccettivo maschile non ormonale
YCT529 : un promettente contraccettivo maschile non ormonale · Per la prima volta la parità dei sessi, in termini di contraccezione, trova ...
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#40Male Birth Control Injection: Options, Research - Healthline
YCT529. Human trials are expected to begin in mid-to-late 2022 on a nonhormonal male birth control pill called YCT529. Research presented at the ...
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#41Pille für den Mann wird 2023 in klinischer Studie getestet
Der neue Wirkstoffkandidat YCT529, der als nicht-hormonelles Kontrazeptivum für Männer entwickelt wurde, konnte im Tierversuch mit Mäusen eine ...
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#42The North-Eastern Chronicle on Instagram: "The findings ...
... the chemical developed by American scientists known as YCT529, was designed to interact specifically with "retinoic acid receptor (RAR) alpha.
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#43Archives des YCT529 - Tonic Radio, Hit & Pop Music
... homme à l'aide d'un composé nommé YCT529 dont le rôle est de bloquer l'action des RAR-alpha, un acide qui permet notamment la croissance des cellules, ...
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#44YCT529: Hoffnung für die hormonfreie Männerpille?
Forscher:innen der University of Minnesota untersuchen seit rund vier Wochen YCT529 – einen neuen experimentellen Wirkstoff, der die Verhütung ...
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#45Male contraceptive pill is safe and effective in tests in mice
He and his colleagues gave male mice a daily dose of a molecule called YCT529 over a four-week period, and found that their sperm count ...
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#46美國研發非荷爾蒙男性避孕藥可大幅降低副作用
這種稱為YCT529的複合物被設計來只與RAR-alpha交互作用，而不會與另兩種相關的受體RAR-beta與RAR-gamma作用，因此可讓副作用降到最小。
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#47What's the Hold-up on Male Contraception?
Another pill, YCT529, is about to enter its first human trial. Experiments on mice showed it to be 99% effective in preventing pregnancy, ...
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#48Will the latest attempt at male contraceptive pills reach the ...
After being administered to male mice for four weeks, YCT529 reduced sperm counts and was 99% effective at preventing pregnancy. And when the ...
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#49Scientists develop male birth control pill that's 99% ...
The compound, dubbed YCT529, targets a protein called the retinoic acid receptor alpha (RAR-α) – a form of Vitamin A that plays an important ...
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#50The Male Pill, a Dream That Is Never Realised | OpenMind
One example is a drug called YCT529, which works by inhibiting the action of retinoic acid needed for sperm maturation (WIN 18,446 functions ...
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#51「男性口服避孕藥」成功率99％、副作用小最快年底人體實驗
他們發現了一種化合物，命名為YCT529，它對RAR-α的抑制作用幾乎是RAR-β和-γ的500倍，當給雄性老鼠口服4周時，YCT529顯著減少了精子數量，並且在預防 ...
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#52YCT-529 - BioWorld
Items Tagged with 'YCT-529'. ARTICLES. Pregnancy test · Nonhormonal male contraceptive prevents pregnancy in partners. March 25, 2022. By Anette Breindl.
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#53Male contraceptive pill could enter human trials in just two ...
The non-hormonal pill, medically named YCT529, blocked 99 per cent of pregnancies in mice during tests — putting it on a par with the female ...
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#54Male contraceptive pill found 99% effective in mice
When administered orally to male mice for four weeks, YCT529 drastically reduced sperm counts and was 99 percent effective in preventing ...
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#55Study of Contraceptive Efficacy & Safety of Phexxi ...
This vaginal gel is called Phexxi™ (previously known as Amphora) and was compared to a commercially available spermicide called Conceptrol®, which contains ...
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#56A birth control pill for men is finally within reach
Researchers discovered a compound that could someday be prescribed as a form of birth control for men. YCT529 blocks a critical vitamin A ...
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#57'99% effective in mice' -- scientists develop male contraceptive ...
“When given orally to male mice for 4 weeks, YCT529 dramatically reduced sperm counts and was 99% effective in preventing pregnancy, ...
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#58陈根：YCT529，男性避孕的新可能 - 财富号
陈根：YCT529，男性避孕的新可能 · 但理想的情况是，这些治疗方法是非荷尔蒙性的以此来减少生理或行为上的副作用。现在，一项新的突破 · 来自明尼苏达大学的 ...
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#59Small Molecule of the Year - 2022 - Drug Hunter
The Vote and Runners-Up · #1: Deucravacitinib (Bristol Myers Squibb, 24%) · #2: MRTX1133 (Mirati Therapeutics/Array BioPharma, 21%) · #3: YCT529 ( ...
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#6099%有效的男性口服避孕药，您会选择吗？
研究对象为一种非激素类男性口服避孕药（YCT529），该药物可实现雄性小鼠的有效避孕，而且没有明显副作用。据研究人员Md Abdullah Al Noman介绍此款 ...
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#61Male contraceptive pill found 99% effective in mice
When administered orally to male mice for four weeks, YCT529 drastically reduced sperm counts and was 99 percent effective in preventing ...
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#62Contraception. Une pilule contraceptive pour les hommes ...
Administré oralement aux souris mâles pendant quatre semaines, YCT529 a drastiquement réduit la production de spermatozoïdes et a été efficace à ...
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#63Male contraceptive pill could be ready for humans in five ...
The key with YCT529 is that it's not a hormonal contraceptive, meaning it doesn't target testosterone, which is the male sex hormone made in the ...
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#64Male Birth Control Explained As New Pill 99 Percent ...
They found that one compound in particular, called YCT529, was effective at doing so. Best of Newsweek via email.
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#65The pill for men: Mice study shows 99% effectiveness
Al-Noman and his colleagues synthesized the compound YCT529 to inhibit the RAR-α protein. “So, we specifically blocked the action of vitamin ...
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#66Male Birth Control Pill 99% Effective on Mice Looks Set ... - VICE
D., found that a compound called YCT529 could inhibit RAR-α alone. The researchers then gave YCT529 orally to male mice over a period of four ...
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#67陈根：男性避孕，未来可选择吃药？ - 知乎专栏
基于此的结果显示，这种种名为YCT529的化合物对RAR-α的抑制作用是它对其他两种相关的RAR蛋白的影响500倍左右，这应该会减少潜在的副作用。 然后，研究人员 ...
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#68今年開始人體試驗，男性避孕藥真要來了 - T客邦
明尼蘇達大學的研究人員開發了一種名為YCT529 的化合物，是一種非激素類男性避孕藥物，而且似乎沒有任何副作用，這種藥物的早期人體試驗預計將於今年 ...
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#69YourChoice Bio: Home
Preventing pregnancy is a lifetime's work for men, too. Birth Control Designed for Men. icono non hormonal_Mesa de trabajo 1.png. Non-Hormonal.
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#70¿Es esta la píldora anticonceptiva masculina más eficaz? - ABC
Un anticonceptivo masculino no hormonal (conocido como yct529; la estructura se muestra aquí) previene el embarazo en ratones al bloquear un ...
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#71Male Birth Control Pill? The New Way to Protect Against ...
Although still in the early stages of animal trials, the compound YCT529 seems to be effective in lowering sperm count and is up to 99% ...
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#72安全方便的男性避孕近在咫尺，但何時才能實現？ - MPlus
... 到輸精管（而是把精子送進尿道）；美國避孕藥公司也在研究一種類似的產品「Vasalgel」；現在還有一種名為YCT529的藥物，它能使老鼠體內的維生素A ...
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#73Gunda I. Georg on Twitter: "@SpermControl Please contact ...
, when will you know if YCT529 can undergo human trials? Is there a date when more information will be released to search for volunteers for the trials? I've ...
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#74Männer, hier kommt Verhütung ohne Schnipp-Schnapp!
Gunda Georg von der University of Minnesota hat den Wirkstoff namens YCT529 ausfindig gemacht, der RAR-α inhibieren kann.
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#75Future Vasectomy Alternatives For Contraception For Men
Researchers indicated that YCT529 could be available in about five years, maybe a bit sooner. Questions About Vasectomies and Alternative ...
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#76男性避孕，未来可选择吃药？ - 澎湃新闻
然后，研究人员通过给雄性小鼠口服四个星期的剂量测试YCT529。果然，动物的精子数量明显减少，并且该药物的避孕效果能够达到99%。研究小组没有观察到任何 ...
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#77Male contraceptive pill is 99% effective, show tests in mice
... the course of four weeks, scientists gave male mice a daily dose of a chemical called YCT529 and discovered that their sperm count fell.
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#78Health Day News - A.D.A.M.
When given orally to male mice for four weeks, YCT529 significantly reduced sperm counts and was 99% effective in preventing pregnancy, without causing any ...
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#79男性口服避孕藥研發成功下半年至年底人體試驗 - 香港01
當雄性小鼠在4週內口服化合物，YCT529顯著減少精子數量，且在預防懷孕方面有99% 的有效性，又沒有任何可觀察到的副作用。小鼠在停止接受該化合物後4至6周 ...
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#80Male Contraceptive Pill: Everything You Need to Know
... non-hormonal, scientific formulation called GPHR-529 or YCT529. The contraceptive was developed by Md Abdullah al Noman, a PhD candidate ...
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#81Dimethandrolone undecanoate shows promise as a male birth ...
A new birth control pill for men appears to be safe when used daily for a month, with hormone responses consistent with effective ...
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#82Kommt jetzt die Antibabypille für den Mann?
YCT529 – ein nicht-hormonelles Verhütungsmittel verhindert eine Schwangerschaft bei Mäusen, indem es bei den männlichen Tieren einen Vitamin-A- ...
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#83Why aren't there hormone-free birth control pills? Roe puts ...
For now, it's known as YCT529. YourChoice chief executive Akash Bakshi and co-founder Nadja Mannowetz launched the company to develop ...
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#84Contraception : une nouvelle pilule pour hommes
Le YCT529 a montré des résultats efficaces à 99 % sur des souris mâles. Pourquoi cette découverte se distingue des précédentes ? Ce contraceptif masculin ...
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#85The male pill can't come fast enough - The Times
After it baffled science for 70 years, researchers at the University of Minnesota have come up with a non-hormonal drug named YCT529.
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#86This Could Be the Best Hope for a Birth Control Pill for Men
When given to male mice daily for four weeks, YCT529 greatly reduced mice sperm counts and ended up being 99 percent effective at preventing ...
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#87Why Isn't There a Birth Control Pill for Men?
There's also YCT529, a non-hormonal pill that reduces sperm counts by targeting a form of vitamin A that plays an important role in sperm ...
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#88American Society of Andrology Spring Conference - 2022
YourChoice Therapeutics is developing the small molecule YCT-529 into an oral, non-hormonal and reversible male contraceptive.
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#89无激素男用避孕药临床前有效率99%，预计年底进入人体试验
他们的化学物质YCT529也被设计成与RAR-alpha，而不是其他两个相关受体RAR-beta和RAR-gamma相互作用，以尽量减少潜在的副作用。 将在5年内上市. 当口服给 ...
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#90They create birth control pills for men 99% effective in clinical ...
When administered orally to male mice for 4 weeks, YCT529 dramatically reduced sperm count and was 99% effective in preventing pregnancy, with ...
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#91動物實驗成功率99％、副作用低男性口服避孕藥將人體試驗
這種稱為YCT529的複合物被設計來只與RAR-alpha交互作用，而不會與另兩種相關的受體RAR-beta與RAR-gamma作用，因此可讓副作用降到最小。
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#92Male contraceptive pill found 99% effective in mice - France 24
When administered orally to male mice for four weeks, YCT529 drastically reduced sperm counts and was 99 percent effective in preventing ...
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#933款男性口服避孕药迎来好消息 - 医谷
YCT529 目前已获美国国立卫生研究院（NIH）和美国男性避孕项目的资助，同时，据研究人员介绍，YCT529已授权给Your Choice Therapeutics公司进行进一步开发 ...
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#94Male Contraceptive Pill Looks Set For Human Trials Soon
D., gave male mice a compound called YCT529, which they found dramatically reduced the mice's' sperm count as well as being 99 percent effective ...
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#95Píldora anticonceptiva masculina tiene 99% de efectividad en ...
YCT529 se administró por vía oral a ratones macho durante 4 semanas y redujo drásticamente el conteo de espermatozoides.
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#96陈根：YCT529，男性避孕的新可能- 世链财经
陈根：YCT529，男性避孕的新可能. 陈述根本; 时间: 03-25; 阅读: 27. 广告 广告. 文/陈根. 男性不愿戴套，女性不愿吃药，这一两性间的避孕矛盾十分常见。
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#97First-ever 'birth control pill' for men moves step closer to reality
The compound called YCT529 made male lab rodents sterile, without any side-effects or harm to related proteins.
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#98今年开始人体试验，男性避孕药真要来了 - 36氪
明尼苏达大学的研究人员开发了一种名为YCT529 的化合物，是一种非激素类男性避孕药物，而且似乎没有任何副作用，这种药物的早期人体试验预计将于今年 ...