➥【SARS-CoV-2透過非結構蛋白「NSP14」關閉宿主的蛋白質合成以助其逃脫宿主的先天性免疫反應】致病性病毒要能克服宿主所產生的第一型干擾素(type 1 interferon，IFN-1)抗病毒先天性免疫反應才能在宿主身上造成感染，而干擾宿主的蛋白質合成是病毒常採行的策略。
　
SARS-CoV-2的非結構蛋白「NSP14」具有核糖核酸外切酶(exoribonuclease，ExoN)和N7甲基轉移酶(N7-methyltransferase，N7-MTase)的活性，是病毒複製不可或缺的蛋白。耶魯大學研究團隊進一步發現，SARS-CoV-2可透過NSP14關閉宿主的蛋白質合成。
　
而ExoN或N7-MTase的活性部位若發生突變，NSP14便會喪失其關閉宿主合成蛋白質的能力。此外，NSP14−NSP10複合物的形成，會增強NSP14關閉宿主合成蛋白質的能力。
　
綜合而言，SARS-CoV-2透過NSP14關閉宿主的蛋白質合成，抑制了IFN-1所活化的干擾素刺激基因(interferon-stimulated genes，ISGs)的表現，進而關閉宿主的先天性免疫反應。
　
此研究增進了醫學界對SARS-CoV-2致病機轉的了解，有助...完整轉譯文章，詳連結：http://forum.nhri.org.tw/covid19/virus/j_translate/j2654/ ( 財團法人國家衛生研究院 吳綺容醫師摘要整理)
　　
📋 (PNAS )Proceedings of the National Academy of Sciences of the United States of America - 2021-06-15
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
■ Author：Jack Chun-Chieh Hsu 1, Maudry Laurent-Rolle, Joanna B Pawlak, et al.
■ Link：https://www.pnas.org/content/118/24/e2101161118.long
　　
〈 國家衛生研究院-論壇 〉
➥ COVID-19學術資源-轉譯文章 - 2021/06/17
衛生福利部
疾病管制署 - 1922防疫達人
疾病管制署
財團法人國家衛生研究院

I'm sorry if the sound in the cat video is too loud. The sound keeps ringing in from the beginning to the end of this video.
Why did things turn out this way? To discover the cause is the purpose of today. The sound was resonating with each other in a paper bag, and it made to play various kinds of music. Moreover, it stimulated my cat's intellectual curiosity. Gathering around by it, one of them found the reason for the problem.
音がうるさかったらごめんなさい。この猫動画は最初から最後までブンブンと音が鳴り続けています。それは、なぜか。というのを解明するのが本日の趣旨です。紙袋の中で共鳴し合う音という音が、さまざまな音色を奏で、猫たちの知的好奇心を刺激します。音に釣られて集まる猫、そして問題の原因とは一体。最後に突き止めたのは、あのニャンコでした。

Tell me about your dreams.

Recently I listened to the podcast by @lucasrockwood where he talks about the power of dreams with @charlie_morley_lucid_dreaming. That we can become more aware of our dreams and how that can help us to be more creative.

This got me thinking, are we resting and sleeping enough? If you ask around, most people will tell you no. And I have heard stories and claims from friends and students that sometimes even after yoga or a workout, they don’t feel more relaxed. Why is that?

I will attempt to answer that. First when we go to a yoga class or a workout, we tend to expect that we must achieve something or trying to reach a state, or gain muscle mass, rather than just trusting the process, having fun and being present. Yes, while trying to achieve a pose might be important, but staying focused and breathing in your class or practice can help you reach mental and spiritual relaxation, which is a higher form of relaxation - the kind that will help you truly relax and sleep.

Secondly, we subject ourselves in a highly stimulated environment: work, smart devices, violent or horror shows, sensationalised news. Try to limit your time you spent on these things. You will definitely find it easier to unwind and relax.

And if all else fails, read a book (this puts me to sleep every time!) and do simple #supinetwist as shown in this picture. If you can’t reach your foot with the leg straight, use a strap or a towel to connect your hand and your foot. Do both sides and in each side stay for about 2-3 minutes.

Assuming you can sleep now and your dreams will flow, @charlie_morley_lucid_dreaming went on to say that we should journal our dreams so that we can build up a memory for our dreams and that will help us become more aware of our dreams. That sounds pretty amazing because dreams are really important. From the dreams that I can remember, sometimes I do find solutions or answers for the things that have been puzzling me at work. Charlie even claims that within a few weeks of dream journaling, you will already start to see results.

Wanna give it a try?

#relaxation #bettersleep #yoga #dreaming #luciddreams #luciddreams #yogaforbettersleep

＜Turn subtitles ON for English translations!＞

前回の英語動画：【小3で挫折→小5で英検1級】英語を話せるようになったマインドセット
https://youtu.be/V_UFXn5_XT4

代々木ゼミナール　2021年度 大学入学共通テスト 問題と解答（朝日新聞デジタル）
https://www.asahi.com/edu/center-exam/shiken2021/1st/day1.html

受験生の皆さん、お疲れ様です。英検やTOEFLを受けていた頃の脳の使い方を思い出して一気に疲弊しました…気楽に自分のペースで勉強するのも良いけど、何かに挑んでいる時って自分を試していると言うか戦ってる感があってそれはそれで良いですよね（たまになら）。
今年から出題内容が変わって、それに伴って学校や塾や予備校の授業内容も大幅に変わったりするのでしょうか。試験に向けての勉強であることに変わりはないとしても、割と実用性の高いテスト内容だった気がしたのでカリキュラムもそうなっていくのだとしたら良い傾向ですよね。でも試験内容の変更を受けて教育現場の教え方が変わるという順番ってどうなんですかね。なんにせよテストに向けての勉強ではあれどそのテストがその後の実社会に活きるものに近づくというのはやっぱり良い傾向ではあるか。教育って全ての根本にあって考えだすと本当にブラックホールですよね。
今回英語のみやってみましたが、これを他の科目も2日間に渡って、さらに受験シーズンなんて何日も何週間にも渡ってこなすなんて、本当にえらいことだなと震えました…
あと中学受験で一時帰国していた時に黒豆を持っていた祖母に「くろちゃん」と呼ばれ「あ、黒豆と間違えちゃった！」（本気）って言われたことを思い出しました。確かにあの頃黒かったけど。
ステイホーム、ハッピーに過ごしましょう！
音楽コンテンツもちろん制作中なので楽しみにしててくださいね！今年もよろしくお願いします。

I truly admire all the students who are taking tons of exams and are studying from dawn to midnight for several months... This exam that I tried this time, is basically a pre- entering test which students who applied for universities take, before taking entering exams. So it's a real big deal for those students in Japan.
In Japan, the goal of studying is to pass these kind of exams for most of the students, and not for actually using what we learned or nurturing the knowledge to another level. (At least that's what I think!) There's an exam, so we study and they teach. I wonder if this structure ever changes in the near future. What's the educational motivation and process like in your countries?
Well it was interesting taking this exam, my brain definitely got stimulated. Music content and other videos are in process, so stick around for more! Thanks as always.

[ 他楽曲のDL/ストリーミングはこちら | Stream and Download my songs!! ]
クリスマスの話：hhttps://big-up.style/pVRuL4sGAu
あなたへ：https://big-up.style/Aw19PGLkxG
24 HOURS :https://big-up.style/TlXomKU1o4
IN THIS BLANKET : https://linkco.re/y4z3tt5V
TORCH : https://linkco.re/vYHNVsFs
LOVE : https://linkco.re/0Ftr3g1N

[ 竹渕慶 | Kei Takebuchi ] FOLLOW ME ON]
Twitter : https://twitter.com/keibambooty
Instagram : https://www.instagram.com/keibamboo/
HP : https://keitakebuchi.com/

[ YAMO (クリエイティブパートナー/Creative Partner）]
点数で負けた方が「1週間英語だけで生活」っていう罰ゲーム案もあったのですが、それはまた別の機会に…！
I was thinking of having the lower scorer speak in English for a week as a penalty. Maybe for another competition next time.
Twitter : https://twitter.com/YAMO_wbsb
Instagram : https://www.instagram.com/yamo_wabisabi/


＜English translation credit: Anna Kato＞


[ その他オススメのビデオ | Other Recommended Videos ]
クリスマスの話：https://www.youtube.com/watch?v=8dbhX...
Torch : https://youtu.be/y9ltZL5osBI
In This Blanket : https://youtu.be/s9MXv28fJsY
ASMR : https://youtu.be/rJe4ebh2AFc
「天気の子」Mash Up : https://youtu.be/ZcT2UOmcwIo

[ グッズ | MERCH 　keit.ソックス販売中！]
https://muuu.com/users/f613d3ed8e46476e

[ オンラインコミュニティーPATREON ]
https://www.patreon.com/KeiTakebuchiYAMO

[お仕事のご依頼、お問い合わせ | Business inquiries]
下記、UUUM株式会社までお願いいたします ↓
https://www.uuum.co.jp/inquiry_promotion

[ファンレター送り先｜Fan letters]
〒107-6228
東京都港区赤坂9-7-1 ミッドタウン・タワー 28階
UUUM株式会社 竹渕慶 宛

Kei Takebuchi（UUUM）
〒107-6228
Midtown Tower 28F, 9-7-1, Akasaka, Minato-ku, Tokyo, Japan

【大象體操 Elephant Gym - 散步 Walk (Official Audio) 】
【"The Blue Tour" - Canada & USA Tour TICKETS ON SALE !💥】
🇨🇦🇺🇸🇨🇦🇺🇸
Since our show on Oct. 05, 2018 in Toronto, Elephant Gym has been to 14 countries, in Europe, Asia, and America. We have put on nearly 100 shows of ＜Underwater World Tour＞ in one year .🌎🌏

We would like to introduce you the song “Walk” from the album ＜Underwater＞ by this animation. We also hope the song will be able to keep you company while you’re strolling.


We regard “Walk” as the song that represents our long journey around the world.👣👣

Like the boy in the animation, we kept going forward and forward for these past years. As he finally left outside the screen and keep on his tour, our journey will keep moving on, too.


This fall, we are invited to perform at Camp Flog Gnaw Carnival, thus, we will launch our second tour in Canada and the west coast of the States with a great Japanese band LITE, this is the ＜The Blue Tour＞.


People often ask us,”Will you get inspired to write new songs during the world tour?” Well, it might not be as powerful as an ”inspiration”, but we truly got stimulated and motivated to make new songs. Thus, our first new single after the album ＜Underwater＞ will be released in two weeks! Also, we’re going to play the new single for the very first time during ＜The Blue Tour＞ in Canada and the U.S.! 🎉

Please enjoy the song “Walk” and keep an eye on our upcoming new single!
See you in Canada and the U.S!💕💕


👇Grab a ticket down down below👇
👉Follow us on instagram: elephant_gym_official
🖌Animation: LOTS Studio 🌟

#Walk #TheBlueTour #Canada #WestUSA
--

從2018年10月5日第一站加拿大多倫多開始，整整一年，大象體操橫跨歐亞美洲 14個國家，經歷將近一百場大大小小的演出。🎶

《水底》專輯裡的這首〈散步〉，是一首希望能陪著大家走路時聽的 歌，或許也可以作為我們這段旅程的註腳。


一直走著的我們，看了好多風景，就像這支動畫中的主角。而動畫中最後離開畫面的他，旅程也依然持續著，就像我們因為受到音樂節邀約，兩週後即將再度前往美洲，展開第二次的加拿大、美國西岸巡演。🎸🎹🥁


之前常常被問到，世界巡迴的過程中，是否會啟發我們寫新歌的靈感？雖然不確定是否能說靈感，但至少會累積創作新曲的慾望，而我們也的確將它完成了，因此，繼《水底》專輯之後的全新單曲，將於我們前往美洲演出前，大約兩週後和大家見面！也將在美西巡迴中首次演出新單曲！✨


#再次呼籲台灣的大家多多加入社團
#這個月還會有在台灣重大事項在社團搶先公布

👉大象體操FB不公開社團：大象體操 Elephant Gym Club
👉Follow us on instagram： elephant_gym_official
🖌動畫製作：LOTS Studio 🌟

---
【Credit】
Production
LOTS Studio

2D animation
李大冠 - Da-Guan Lee
陳忠暐 - Chen Zhong Wei
曾芝盈 - Zhi Ying Zeng
黃才容 - Huang Cai-Rong
倪璦 - NI AI

VFX
李大冠 - Da-Guan Lee
曾芝盈 - Zhi Ying Zeng

---
👇👇馬上購票 Tickets💕💕

【Elephant Gym 2019 "The Blue Tour" - Canada & USA 🇨🇦🇺🇸】

10/28 Vancouver - The Biltmore Cabaret w/LITE
https://bit.ly/2SAXX6h

10/29 Seattle - Neumos w/LITE
https://bit.ly/2GvuqGD

10/30 Portland - Paris Theatre w/LITE
https://bit.ly/2YdXHAB

11/01 Berkeley - Cornerstone Craft Beer & Live Music w/LITE
https://bit.ly/2yanie8

11/02 Sacramento - Harlow's w/LITE
https://bit.ly/2YwrMKG

11/03 Los Angeles - The Roxy Theatre w/LITE
https://bit.ly/32XiHdA

11/04 San Diego - Music Box w/LITE
http://bit.ly/2lTCQQy

11/06 Phoenix - The Rebel Lounge w/LITE
https://bit.ly/2Om01kq

11/09 Los Angeles - Camp Flog Gnaw Carnival 2019

Today’s video features a very famous Malaysian food, prawn mee, in Sibu, Sarawak. Apart from its authentic taste and thick broth which stimulated my smell receptors and taste bugs, what caught my attention are the gigantic Rajang River’s prawns that are served together with the noodles which perfectly complemented the stir-fried noodles and prawn shell broth. Believe me when I say it’s the number one prawn mee in Sibu and I dare you to challenge me after watching this video.
If you like the video today, don’t forget to subscribe, like and share!
Thank you and see you next time! =)

Address: 45, Jalan Tuanku Osman, 96000 Sibu, Sarawak, Malaysia.
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今天这一期介绍的是砂拉越诗巫最道地，最名副其实，最道地的美食 – 虾面。当老板把虾面呈上，那扑鼻而来的虾黄味及浓郁的虾壳汤已经无限刺激我的嗅觉和味觉。但最吸引我的是呈在面上的拉浪江大虾。大虾搭配传统的炒面及浓厚的虾壳汤，只能由粗俗的‘最有料虾面‘来形容这碗艺术。相信我，绝对没有夸张，这绝对是诗巫最有料的虾面。不相信我说的话？那就通过这个影片来一探究竟。
如果你喜欢今天的影片，记得订阅，点赞及分享！
谢谢大家，我们下次再见！ =）
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地点：45, Jalan Tuanku Osman, 96000 Sibu, Sarawak, Malaysia.

Song: Damon Empero ft. Timmy Commerford - Lost
Link: https://youtu.be/alYg3WLea9g
Released by Outertone. Promoted by FMW.

Song: NOWË - Heart Of Gold (Vlog No Copyright Music)
Music provided by Vlog No Copyright Music.
Video Link: https://youtu.be/EALgD9ZjFyo

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