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#1Solenopsin - Wikipedia
Solenopsin is a lipophilic alkaloid with the molecular formula C17H35N found in the venom of fire ants (Solenopsis). It is considered the primary toxin in ...
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#2Solenopsin, the alkaloidal component of the fire ant ...
Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and ...
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#3Solenopsin - bionity.com
Solenopsin (C17H35N)is an alkaloidal component of fire ant ( Solenopsis invictica) that potently inhibits angiogenesis via the phosphoinositol-3 kinase ...
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#4Solenopsin A, a Venom Alkaloid from the ... - Oxford Academic
Solenopsin A (trans-2-methyl-6-undecylpiperidine; solenopsin), a venom alkaloid from the fire ant Solenopsis invicta, exhibits global structural similarity to 3 ...
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#5Ant Venom - an overview | ScienceDirect Topics
SOLENOPSIN (piperidine alkaloids are also known as hemolytic factors and induce histamine release); 6. FIRE ANTS (Solenopsis invicta); 7. α-LACROTOXIN; 8.
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#6(PDF) Solenopsin, the alkaloidal component of the fire ant ...
Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and ...
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#7Solenopsin | Akt Inhibitor | MedChemExpress
[1]. Arbiser JL, et al. Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3- ...
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#8Fire ant venom compounds may lead to skin treatments
Solenopsin analogs can reduce skin thickening and inflammation in a mouse model of psoriasis, scientists have shown.
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#9solenopsin - Wiktionary
EtymologyEdit. From translingual Solenopsis (“genus that includes fire ants”) + -in. NounEdit. solenopsin (usually uncountable, plural solenopsins).
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#10A Versatile Synthesis of (±)-Solenopsin A - J-Stage
A versatile total synthesis of fire ant venom, solenopsin A (1), is described. ... Stereoselective syntheses of solenopsin A and B. Tetrahedron Letters.
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#11Solenopsin A, a venom alkaloid from the fire ... - Scripps VIVO
Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa. Academic Article. uri icon.
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#12Solenopsin A, a Venom Alkaloid from the Fire Ant ... - jstor
Solenopsin A, a Venom Alkaloid from the Fire Ant Solenopsis invictOy. Inhibits Quorum-Sensing Signaling in Pseudomonas aeruginosa.
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#13Solenopsin | Others | 陶术生物
Solenopsin is an ATP-competitive inhibitor of AKT(IC50 : 10 μM) .
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#14Fire Ant Venom Could Be a Surprising New Treatment For ...
New research, led by a team from Emory University, has found that solenopsin – the alkaloid that constitutes the chief toxic component in ...
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#15An efficient synthesis of (±) solenopsin A - De Gruyter
Synthesisof (±) solenopsinA 63δ 156.7, 141.0, 137.0, 128.2, 128.0, 127.8(2C), 126.7, 115.4, 74.2, 71, 54.7, 51.6, 37.4, 28.5(3C).
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#16Topical solenopsin analogs improve inflammation and ...
Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of ...
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#17and methods related thereto - WIPO Patentscope
This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure ...
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#18Best 1 Definitions of Solenopsin - YourDictionary
What does solenopsin mean? (biochemistry) An alkaloid with chemical formula C17H35 that inhibits angiogenesis via the phosphoinositol-3 kinase sign...
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#19Medline ® Abstract for Reference 36 of 'Stings of imported fire ...
RESULTS (+/-)-Solenopsin A dose dependently (3-30 mg/kg [10 to 104 micromol/kg]) depressed cardiovascular function. Maximal percent changes following ...
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#20Solenopsin | Targetmol
Solenopsin is an ATP-competitive inhibitor of AKT(IC50 : 10 μM) .
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#21Fire ant venom compounds may lead to skin treatments
Arbiser and his colleagues devised two solenopsin analogs that look like ceramides, but can't be degraded into S1P. They then tested them in a ...
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#22Coniine, (−)-Solenopsin A, (−)-Solenopsis fugaz venom and...
Diastereo- and Enantioselective Syntheses of (−)-Coniine, (−)-Solenopsin A, (−)-Solenopsis fugaz venom and (−)-Xenovenine via ...
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#23Akt Pathway Inhibition of the Solenopsin Analog, 2 ...
Solenopsin A, an alkaloid component of fire ant venom, has been reported to be an Akt inhibitor that can antagonize Akt cellular activity in vitro (18, 19).
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#24台灣入侵紅火蟻與熱帶火蟻毒液生物鹼的化學生態與殺蟲毒理之 ...
Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and ...
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#25Solenopsin A and analogs exhibit ceramide-like biological ...
Both cis and trans analogs of solenopsin reduce mitochondrial oxygen consumption, increase reactive oxygen, and kill tumor cells with elevated levels of Akt ...
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#26Inderscience web site uses cookies.
Title: Computational approach to reveal the modulation of Wnt and TGF-β signalling induced by Solenopsin B, an ant venom alkaloid ... Abstract: Recently, ...
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#27N-苄基内酰胺的两步催化转化为生物碱（±）-Solenopsin，（±）
A procedure‐economical synthesis of 2,6‐trans‐substituted piperidine alkaloids is described. The method consists of Ir and Cu catalyzed ...
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#28solenopsin | C17H36ClN | ChemSpider
solenopsin. Molecular FormulaC17H36ClN; Average mass289.927 Da; Monoisotopic mass289.253632 Da; ChemSpider ID13172015. defined stereocentres ...
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#29CHEBI:80722 - (-)-Solenopsin A - EMBL-EBI
ChEBI Name, (-)-Solenopsin A. ChEBI ID, CHEBI:80722. Stars, This entity has been manually annotated by a third party. Supplier Information, ZINC000030731497.
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#30Solenopsin a, b and analogs as novel angiogenesis inhibitors
The present invention relates to solenopsin A and its analogs for use as angiogenesis inhibitors. The present compounds unexpectedly exhibit good activity ...
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#31Solenopsin | ≥99%(HPLC) | ATP-competitive AKT inhibitor
Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . Preparing Stock Solutions. Concentration / Solvent ...
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#32Dearomatization of N-Phenyl-2,6-dialkylpiperidines - Thieme ...
Abstract: The fire ant venom alkaloid (±)-solenopsin A was pre- pared in 4 steps (34%) starting from the N-phenyl-2-undecyl pipe- ridine (1c).
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#33Asymmetric synthesis. 6. Practical synthesis of (+)-solenopsin A
Application to the Synthesis of (+)-Solenopsin A. The Journal of Organic Chemistry 2009, 74 (5) , 1988-1993. https://doi.org/10.1021/ ...
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#34When It Comes to Treating Psoriasis, Venom May Fill the Void
Solenopsin is found abundantly in our sometimes not-so-friendly animal neighbors, fire ants. Doubtlessly, fire ant venom is extremely harmful ...
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#35SOLENOPSIN | CAS#:137038-57-4 | Chemsrc
Chemsrc provides SOLENOPSIN(CAS#:137038-57-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc.
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#36Highly Regioselective α-Addition of Alkynyl and Alkenyl ...
... Alkynyl and Alkenyl Grignard Reagents to 1-Alkoxycarbonylpyridinium Salts and Its Application to Synthesis of 1-Azabicycloalkanes and (±)-Solenopsin A.
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#37Antibacterial Activity of Synthetic Fire Ant Venom - The ...
Key Indexing Terms: Antibacterial; Fire ant venom; Solenopsin; Isoso- lenopsin; Synthetic alkaloids. [Am J Med Sci 2009;338(4):287–291.].
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#38Total synthesis of Solenopsin - Organic Chemistry Data
Reaction scheme for total synthesis of the natural product Solenopsin. Total synthesis of Solenopsin: Reference: Reding, M. T.; Buchwald, ...
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#39Thesis Final Draft - Uncg
that solenopsin A is suppressing the phosphatidylinositol-3-kinase (PI3K)/Akt pathway by inhibiting a step in the signaling cascade upstream PI3K.2.
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#40SOLENOPSIN-A;(2R,6R)-2-METHYL-6-UNDECYLPIPERIDINE
13C NMR of SOLENOPSIN-A;(2R,6R)-2-METHYL-6-UNDECYLPIPERIDINE.
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#41File:Solenopsin.png - Wikimedia Commons
File:Solenopsin.svg is a vector version of this file. It should be used in place of this PNG file when not inferior.
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#42Fire Ant Venom Alkaloids Inhibit Biofilm Formation - MDPI
The solenopsin alkaloids presented antimicrobial activity at concentrations ranging from 750 to 5000 μg/mL, yielding mean diameters of inhibition halos between ...
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#43signalling induced by Solenopsin B, an ant venom alkaloid
Recently, therapeutic prospect of solenopsin A was reported with emphasis on the inhibition of angiogenesis by antagonising Akt and ...
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#44Authors - The Buchwald Research Group
The enantioselective syntheses of (S)-coniine and (2R,6R)-trans-solenopsin A are reported. The key step in both syntheses is the catalytic asymmetric ...
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#45Solenopsin A and analogs exhibit ceramide-like biological ...
Solenopsin has structural similarities to ceramide, a major endogenous regulator of cell signaling and cancer therapy induced apoptosis. Methods ...
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#46Cutaneous manipulation with topical solenopsin formulations ...
Cutaneous manipulation with topical solenopsin formulations of the KC-Tie2 murine model of psoriasis · Abstract: Psoriasis is a multifaceted disorder known to ...
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#47solenopsin via Pd-catalyzed N-alkylation and cyclization
ABSTRACT. Synthesis of (+)-solenopsin, a 2,6-disubstituted piperidine alkaloid, isolated from fire ants (Solenopsis), was achieved.
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#48Fire ant venom may lead to skin treatments | Emory University
Arbiser and his colleagues devised two solenopsin analogs that look like ceramides, but can't be degraded into S1P.
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#49Springer-Verlag 1996 - USDA ARS
onstrate chat cis- and trans-solenopsin. A (1 and 4) are acetate-derived. Based on our previous results on the biosynthesis of insect alkaloids (tetra-.
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#50Solenopsin and derivatives, therapeutic compositions - Justia ...
This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto.
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#51Toxic Components of Fire Ant Venom Reduce Inflammation in ...
Solenopsin A is a venom alkaloid from the fire ant that chemically resembles ceramides. These lipid-like molecules are found in many skin ...
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#52Solenopsin A | Semantic Scholar
Background(−)-Solenopsin A is a piperidine alkaloid that is a component of the venom of the fire ant Solenopsis invicta… Expand. figure 2. figure 3.
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#53solenopsin - Wikidata
solenopsin A; solenopsine A; (2R,6R)-2-methyl-6-undecylpiperidine. In more languages. edit. Statements. instance of · chemical compound. 1 reference.
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#54solenopsin A | Health & Environmental Research Online (HERO)
An efficient synthesis of (+/-) solenopsin A. Author(s). Arevalo-Garcia, EB. Year. 2012. Is Peer Reviewed?
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#55Computational approach to reveal the modulation of Wnt and ...
Recently, therapeutic prospect of solenopsin A was reported with emphasis on the inhibition of angiogenesis by antagonising Akt and ...
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#56Synthesis of trans-Z,6=Dialkylpiperidines by 1,3-Cycloaddition ...
ant-venom alkaloid, solenopsin. Recent reports' on the synthesis of trans-2,6- dialkylpiperidines from tetrahydropyridine oxide by cycload-.
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#57Small Molecule Derivatives of Solenopsin for Cancer Treatment
Solenopsin is an alkaloid which contributes to the toxic effect of fire ant venom. Solenopsin inhibits angiogenesis via the PI3-K signaling ...
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#58solenopsin - definition and meaning - Wordnik
solenopsin : An alkaloid with chemical formula C17H35 that inhibits angiogenesis via the phosphoinositol -3 kinase signaling pathway, in addition to ...
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#59Solenopsin A, a venom alkaloid fr... preview & related info
Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa.
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#60Fire ant venom to combat thick skin - Outsourcing Pharma
According to the research, mice treated with solenopsin analogs displayed decreases in skin thickness and had fewer immune cells ...
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#61Solenopsin A and analogs exhibit ceramide ... - Vascular Cell
Solenopsin has structural similarities to ceramide, a major endogenous regulator of cell signaling and cancer therapy induced apoptosis. Methods.
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#62N‐Phenyl‐2‐Methylpiperidine: A Short Synthesis of (+)
Solenopsin A 1 together with its cis isomer isosolenopsin A 2 (Fig. 1), are constituents of nonproteinaceous piperidine alkaloids secreted by the fire ant ...
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#63Enantioselective Syntheses of 2-Alkyl - Figshare
... and 2,6-Dialkylpiperidine Alkaloids: Preparations of the Hydrochlorides of (−)-Coniine, (−)-Solenopsin A, and (−)-Dihydropinidine.
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#64SOLENOPSIN - 表面处理联盟
Solenopsin 是一种ATP-竞争型AKT 抑制剂， with IC50 值为10 μM. 产品名称. 中文名. SOLENOPSIN. 英文名. SOLENOPSIN. 中文别名. 英文别名 ...
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#65(S)-(+)-2-Methylpiperidine 97 3197-42-0 - Sigma-Aldrich
Anodic Cyanation of (-)-N-Phenyl-2-Methylpiperidine: A Short Synthesis of (+)-Solenopsin A and (+)-Isosolenopsin A. Girard N, et al.
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#67Solenopsin A and analogs exhibit ceramide-like ... - PermeGear
Solenopsin A and analogs exhibit ceramide-like biological activity. August 9, 2019. Sorry you can't see this Memphis Documents file you don't have the ...
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#68Solenopsin TM-T12972 | CymitQuimica
Solenopsin is an ATP-competitive inhibitor of AKT(IC50 : 10 μM) . Long term storage: Notes: Chemical properties. Molecular weight: 253.47. Formula: C17H35N.
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#69Fire Ants: Symptoms and Treatments - Healthline
... by biting to hold the skin stable, and then sting repeatedly, injecting a toxin alkaloid venom called solenopsin. We refer to this action as “stinging.”.
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#70Fire Ant Venom: A New Compound Discovered for Psoriasis ...
The study also applied the solenopsin analogues to cultures of skin dendritic cells, which resulted in decreased production of the inflammatory ...
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#71Modified Fry Cyanation of a Chiral Pyridinium Salt - Archive ...
This protocol has been applied to the asymmetric syntheses of piperidine alkaloids (-)-coniine and (-)-solenopsin A.
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#72Problems Ants Bring to Virginia Homes - Pest Control
On the tip of its abdomen, a fire ant has a stinger that injects an alkaloid venom called solenopsin. They use this venom to subdue small animals.
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#73What does SOLENOPSIN mean? - Definitions.net
Solenopsin is an alkaloid which inhibits angiogenesis via the phosphoinositol-3 kinase signaling pathway, in addition to contributing to the toxic effect of ...
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#74Toxic vs Solenopsin - What's the difference? | WikiDiff
As a noun solenopsin is. (biochemistry) an alkaloid with chemical formula c17h35 that inhibits angiogenesis via the phosphoinositol-3 kinase signaling ...
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#75SOLENOPSIN | Cas# 137038-57-4 - 美国GlpBio
Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . [1]. Arbiser JL, et al. Solenopsin, the alkaloidal component of the fire ant ...
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#76Component of fire ant venom shows promise as a psoriasis ...
In a new study involving laboratory mice, researchers have found that solenopsin and similar compounds could be beneficial for psoriasis.
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#77Small Molecule Derivatives of Solenopsin for Cancer Treatment
Solenopsin inhibits angiogenesis via the PI3-K signaling pathway. PI3K and its downstream effector Akt, play a major regulatory role in control of apoptosis, ...
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#78Toxin In Fire Ant Reduces Inflammation In Psoriasis - Medindia
Solenopsin analogs which were developed reduced skin thickness and inflammatory cells. The venom of fire ants is found to contain compounds that ...
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#79solenopsinの意味・使い方・読み方 | Weblio英和辞書
solenopsin の意味や使い方 Structure diagram of solenopsin語源From Translingual Solenopsis (“genus that includes fire ants”) + ... - 約1175万語ある英和辞典・ ...
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#80[Letter] Rapid access to trans-2,6-disubstituted piperidines
Expedient syntheses of (-)-solenopsin A and (+)-epi-dihydropinidine are reported, the key step in both being the one-pot multicomponent aza- ...
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#81medical problems and treatment considerations for the red ...
alkaloid, Solenopsin A) are toxic to cells and cause a pustule to form by killing cells at the site of the injection. These dead cells attract the.
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#82Fire ant venom offers new option for psoriasis - Futurity.org
Arbiser and his colleagues devised two solenopsin analogs that look like ceramides, but can't be degraded into S1P.
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#83United States Patent (19)
Of the piperidine alkaloids, Solenopsin A and Sole nopsin B are the two major component with Solenopsin. A being the primary component.
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#84Solenopsin A and analogs exhibit ... - Springer Medizin
Solenopsin A is a piperidine alkaloid that is a component of the venom of the fire ant Solenopsis invicta . Previously, we demonstrated that ...
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#85Fire Ant Venom Toxin Analogs Improve Psoriasis in Mice
Scientists in the U.S. have developed compounds derived from solenopsin in fire ant venom, which helped to reduce skin thickening and ...
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#86Bioorganic Synthesis: An Introduction - 第 7-3 頁 - Google 圖書結果
n n N H n = 4, cis-solenopsin A n = 5, cis-solenopsin B n = 6, cis-solenopsin ... trans-solenopsin C O O 8 x SCoA malonyl-CoA O O reductions, dehydrations, ...
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#87Solenopsin A - Medical Dictionary
One of several alkaloidal constituents present in the venom of the imported fire ant, Solenopsis saevissima; the venom has necrotoxic, hemolytic, ...
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#88Fire Ant Venom Compounds May Lead to Skin Treatments
Solenopsin analogs tested in mouse model of psoriasis. ... mouse psoriasis model, after treatment with solenopsin analog or control cream.
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#89Scientists Think Psoriasis Could be Cured With... Fire Ants
“We believe that solenopsin analogs are contributing to full restoration of the barrier function in the skin,” Jack Arbiser, Professor of dermatology at Emory ...
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#90Fire ant stings: pathophysiology and natural remedy
Composition & Actions of Fire Ant Venom 95%: Solenopsin A Angiogenesis inhibitor neuronal NO synthase inhibitor Cytotoxic (muscles, nerves, ...
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#92Fire Ant Venom Compounds May Lead To Skin ... - DoveMed
Solenopsin analogs can reduce skin thickening and inflammation in a mouse model of psoriasis, scientists have shown.
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#93Alkaloids: Chemical and Biological Perspectives
H (C=O) H (OH trans-267K trans-269C Figure 37 (continued) The absolute configuration of the ant piperidine solenopsin B (trans-2-methyl-6dodecylpiperidine) ...
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#94Arthropod Venom Components and Their Potential Usage
increase in market demand, particularly considering the number of other biotech applications proposed for solenopsin alkaloids (reviewed in [20]). 3.2.
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#95Fortschritte der Chemie organischer Naturstoffe / Progress ...
R=SO2CH3 (+)-86; (+)-solenopsin A (a) DIBALH, CH2Cl2; (b)77, BuOK, THF, (c) H2, Pd/C, EtOH, AcOEt; (d) (PhCOO)2, CHCl2, K2CO3; (e) LiOH, THF/MeOH, ...
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#96The Alkaloids: Chemistry and Pharmacology
Reduction of 7 with a new reagent, LiAlHa-MegA1, gave (+)-solenopsin A (1d, 95%) and its isomer (1c, 5%) (395). In a similar manner, (+)-solenopsin B (1f, ...
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#97Fire Ants: The Sting that Burns | Nature's Poisons
Solenopsin inhibits angiogenesis and neuronal nitric oxide synthase (nNOS). Angiogenesis is the process of making new blood vessels and is ...
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