雖然這篇GalNAc鄉民發文沒有被收入到精華區：在GalNAc這個話題中，我們另外找到其它相關的精選爆讚文章
[爆卦]GalNAc是什麼？優點缺點精華區懶人包
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#2GalNAc-siRNA Conjugates: Leading the Way for ... - PubMed
由 AD Springer 著作 · 2018 · 被引用 209 次 — GalNAc-siRNA conjugates are a simple solution to the siRNA delivery problem for liver hepatocytes and have shown the RNAi (and antisense oligonucleotide) field ...
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#3N-Acetyl- D -galactosamine 98 1811-31-0 - Sigma-Aldrich
Bulk and Prepack available | Sigma-A2795; 2-Acetamido-2-deoxy-D-galactose | D-GalNAc | N-Acetylchondrosamine; CAS No. 1811-31-0; Explore related products, ...
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#4Review Delivery of Oligonucleotides to the Liver with GalNAc
Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc) conjugates that bind to the ...
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#5GalNAc-siRNA Conjugates: Leading the Way for Delivery of ...
Unlike complicated LNP formulations, GalNAc-siRNA conjugates are a simpler, smaller, and compositionally defined approach for hepatic delivery.
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#6GalNAc (N-Acetylgalactosamine) Labeling - Products
GalNAc (N-Acetylgalactosamine) Labeling ... A directed approach to the delivery of therapeutic oligonucleotides specifically to the liver has been to target the ...
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#7Characterizing the effect of GalNAc and phosphorothioate ...
In order to fully characterize the effect of GalNAc valency, oligonucleotide length, flexibility and chemical composition on ASGR binding, we tested and ...
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#8UDP-Azido-GalNAc ES103-100 - R&D Systems
Incorporate or detect GalNAc without expensive, specialized equipment! Applications. For in vitro enzymatic incorporation of azido-sugars into specific, ...
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#9tri-GalNAc COOH Supplier | CAS 1953146-81-0 - Tocris ...
View and buy high quality tri-GalNAc COOH from Tocris Bioscience. Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward ...
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#10GalNAc conjugates: Delivery service to the liver! - Bachem
GalNAc (Scheme 1) is a carbohydrate moiety that binds to the highly liver-expressed asialoglycoprotein receptor 1 (ASGR1) with high affinity (Kd ...
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#11The crystal structure of UDP-GalNAc:polypeptide α-N ... - PNAS
A model of a mucin 1 glycopeptide substrate bound to the enzyme shows that the spatial separation between the lectin α site and a modeled active site UDP-GalNAc ...
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#12Structure of GalNAc and GlcNAc: (a) GalNAc and (b) GlcNAc.
Download scientific diagram | Structure of GalNAc and GlcNAc: (a) GalNAc and (b) GlcNAc. from publication: A New HPLC-ELSD Method for Simultaneous ...
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#13Efficient Synthesis and Biological Evaluation of 5′-GalNAc ...
Conjugation of triantennary N-acetyl galactosamine (GalNAc) to oligonucleotide therapeutics results in marked improvement in potency for ...
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#15siRNA Delivery: GalNAc Conjugates and LNPs - Alnylam ...
GalNAc conjugates – GalNAc, or N-acetylgalactosamine, is a sugar molecule that can recognize and bind to a cell surface protein, the asialoglycoprotein receptor ...
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#16Anti-GalNAc-TL5 Antibody (F-5) | SCBT
GalNAc -TL5 Antibody (F-5) is a monoclonal anti-GalNAc-TL5 antibody that detects m, r, and h GalNAc-TL5 by WB, IP, IF and ELISA. Cited in 1 publications.
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#17A GalNAc/Gal-specific lectin modulates ... - RSC Publishing
A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability† · * · Department of Biotechnology ...
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#18A GalNAc/Gal-specific lectin modulates immune responses via ...
A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability · 閱讀文章 · 摘要.
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#19O-GalNAc Modified Glycoprotein Assay Kit (FACS ...
The O-GalNAc Modified Glycoprotein Assay Kit (FAC/Microscopy, Green Fluorescence)(ab235629) is a highly specific, simple and robust method for labeling and ...
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#20Selection of GalNAc-conjugated siRNAs with limited off ...
The subset of GalNAc-siRNAs that show rat hepatotoxicity is not advanced to clinical development. Potential mechanisms of hepatotoxicity can be ...
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#21The GalNAc-T Activation (GALA) Pathway: Drivers and markers
The enzymes GALNTs add GalNAc sugar to Ser and Thr residues, forming the Tn glycan. GALNTs are activated by trafficking from Golgi to ER, ...
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#222D7I: Crystal structure of pp-GalNAc-T10 with ... - RCSB PDB
Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10) · PubMed: 16650853 ...
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#23The Nonclinical Disposition and PK/PD Properties of GalNAc ...
Upon subcutaneous administration, GalNAc-conjugated siRNAs are quickly distributed to the liver, resulting in plasma pharmacokinetic (PK) ...
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#24tri-GalNAc COOH (7401) | Bio-Techne
Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an ...
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#26GalNAc-Conjugated Oligonucleotides: A Comparison of Solid ...
Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy.
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#27N-Acetyl-D-galactosamine | 1811-31-0 | Biosynth Carbosynth
It is suggested that alterations of GalNAc attachment in IgA may be useful as a novel diagnostic and prognostic marker of Crohns Disease (Inoue, 2012).
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#28Kidney N-Acetylgalactosamine (GalNAc) - Journal of ...
The purified enzyme phosphorylates GalNAc, but not galactose, galactosamine, glucose, GlcNAc, or glucosamine. This enzyme may represent part of a salvage ...
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#29Biochemical Roles of Eukaryotic Cell Surface Macromolecules: ...
Table 4.3 Structure of the major components in the digest of CS-D with HYAL4 Fraction Structure of the productsa D-1 GlcUA-GalNAc(4S)-GlcUA(2S)-GalNAc(6) ...
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#30Lipid nanoparticles incorporating a GalNAc ligand enable in ...
Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates.
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#31GalNAc L-threonine - Dextra Laboratories
GalNAc L-threonine. GalNAc L-threonine. Product Code: G-T004. Pack Size. 100 mg, £ 663.00 each. +. –. Add to cart. 250 mg, £ 1,409.00 each.
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#32MOLECULAR SIGNATURE® Anti-O-GalNAc Antibody [9B9]
O-GalNAc Antibody - Mouse monoclonal antibody to O-Linked N-Acetylgalactosamine, clone 9B9. Species Independent. Validated for WB, ICC/IF, and ELISA.
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#33dR-GalNAc (Beta) Phosphoramidite - LGC, Biosearch ...
Phosphoramidite for N-Acetylgalactosamine (GalNAc) incorporation in an oligonucleotide.
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#34GalNAc-α-O-benzyl Inhibits NeuAcα2-3 Glycosylation and ...
Exposure for 24 h of mucus-secreting HT-29 cells to the sugar analogue GalNAc-α-O-benzyl results in inhibition of Galβ1-3GalNAc:α2,3-sialyltransferase, ...
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#35Trebler GalNAc azide - Primetech
N-acetylgalactosamine (GalNAc) modification of oligonucleotides including siRNAs, anti-miRs, and ASOs.
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#36GalNAc-siRNA合成-Umibio Science and Technology Group
GalNAc -siRNA合成 (5OD – 500 OD). GalNAc-siRNA是糖类化合物与siRNA形成的单缀合物。GalNAc是唾液酸受体（ASGPR）的靶向性配体，其与肝脏表面细胞具有较高的亲和力及 ...
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#37Intermediate Subunit of the Gal/GalNAc Lectin of Entamoeba ...
ABSTRACT Killing by Entamoeba histolytica requires parasite adherence to host galactose- andN-acetyl-d-galactosamine (Gal/GalNAc)-containing ...
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#38ChEBI - GlcNAc- (1→3)]- D- GalNAc- ol - EMBL-EBI
An oligosaccharide derivative consisting of -D-GalNAc-ol at the reducing end with a D-GalNAc-(1→4)-D-GlcNAc moiety attached via a (1→6)-linkage and a [D- ...
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#39diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D ... - UniProt
GalNAc -alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase. Gene. pglH. Organism. Campylobacter jejuni ...
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#40Deconstruction of O‐glycosylation—GalNAc‐T isoforms direct ...
GalNAc -type O-glycosylation is found on most proteins trafficking through the secretory pathway in metazoan cells. The O-glycoproteome is regulated by up to ...
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#41Activation of the C-Type Lectin MGL by Terminal GalNAc ...
Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells.
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#42Antibodies directed against GalNAc- and GlcNAc-O-Tyrosine ...
Antibodies directed against GalNAc- and GlcNAc-O-Tyrosine posttranslational modifications – a new tool for glycoproteomic detection.
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#43Anti-Antiproliferative Factor (Gal-GalNAc-TVPAAVVVAC ...
This rabbit polyclonal antibody was generated against a cysteinylated two-sugar antiproliferative factor (APF) derivative (Gal-GalNAc-TVPAAVVVAC) and ...
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#44SLN124, a GalNAc Conjugated 19-Mer Double-Stranded ...
SLN124, a GalNAc Conjugated 19-Mer Double-Stranded SiRNA Reduces Iron and Increases Hepcidin Levels of Healthy Volunteers in a Phase 1 Clinical ...
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#45The Nonclinical Safety Profile of GalNAc ... - SAGE Journals
A number of N-acetylgalactosamine (GalNAc)-conjugated siRNAs (GalNAc-siRNAs), also referred to as RNA interference (RNAi) therapeutics, ...
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#46N-Acetyl-α-D-galactosamine | C8H15NO6 | ChemSpider
More details: ... GalNAc-??. GalNAc-??; N-acetyl-2-deoxy-2-amino-galactose; N-acetyl-α-D-galactosamine; N- ...
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#47Anti-GalNAc-T3 [UH5] monoclonal antibody - Ximbio
GalNAc -T3 is one of many polypeptide GalNAc-transferases that attach GalNAc to proteins forming the GalNAc 1-O-Ser/Thr linkage for GalNAc-type ...
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#48N-acetylgalactosamine or GalNAc - Bio-Synthesis Inc
N-acetylgalactosamine, or n-acetyl-a-D-galactosamine, alpha-GalNAc; TN saccharide; alpha-GalpNAc; GalNAc-alpha; n-acetyl-a-d-galactosamine; ...
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#49GalNAc-T6 enzyme selectively up-regulated in colon ...
GalNAc -T6 enzyme selectively up-regulated in colon adenocarcinomas - Researchers have identified an enzyme that appears to drive the ...
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#50反相双柱连续色谱法纯化GalNAc 簇缀合寡核苷酸 - X-MOL
Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) is a continuous chromatography technique used to maximize purification ...
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#51Lymphocyte Homing Receptors: Advances in Research and ...
Central Institute of Laboratory Medicine and Pathobiochemistry, Berlin: N-glycan analysis of recombinant L-Selectin reveals sulfated GalNAc and ...
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#52N-乙酰半乳糖胺- 搜狗科学百科
N-乙酰半乳糖胺（N-Acetylgalactosamine, GalNac）是半乳糖的一种氨基糖衍生物，其在血型识别、蛋白质糖基化等生理现象中有重要意义，近年来亦被用于 ...
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#53Abstract 3300: Gal-GalNAc overexpressed in colorectal ...
Abstract 3300: Gal-GalNAc overexpressed in colorectal carcinoma mediates attachment and colonization of Fusobacterium nucleatum utilizing the ...
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#54GalNAc (N-Acetyl-D-Galactosamine), 98% - Rose Scientific
GalNAc (N-Acetyl-D-Galactosamine), 98%. Overview. An amino sugar that is a component of many O-linked and N-linked glycan structures. As UDP-GalNAc, GalNAc ...
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#55The Nonclinical Safety Profile of GalNAc ... - ScienceOpen
A number of N-acetylgalactosamine (GalNAc)-conjugated siRNAs (GalNAc-siRNAs), also referred to as RNA inter- ference (RNAi) therapeutics, are currently in ...
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#56GALNAC-T2 siRNAs - Thermo Fisher
13 GALNAC-T2 Silencer Select Pre-designed, Validated, and Custom siRNA in Standard, HPLC, and In-vivo Ready Purities.
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#57β-GalNAc-PEG3-azide (O-link) - Conju-Probe
β-GalNAc-PEG3-azide (O-link) is a PEGylated glycoside functionalized with an azide. PEGylated glycosides are used as ligands for Click Chemistry.
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#58Core 1 O-GalNAc glycosylation in the human cell nucleus.
Cejas et al. Biol Chem. 2019. Glycosylation is a very frequent post-translational modification in proteins, and the initiation of O-GalNAc ...
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#59Gal beta(1-3)GalNAc-alpha-Thr 97.0 %, TCI America - Fisher ...
TCI America™-Gal beta(1-3)GalNAc-alpha-Thr 97.0+% Shop Gal beta(1-3)GalNAc-alpha-Thr 97.0+%, TCI America™ at Fishersci.com.
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#60Glycoprotein hormone GalNAc-4-sulphotransferase - Portland ...
GalNAc -4-ST1 is most highly expressed in pituitary, cerebellum and other regions of the brain. The terminal GalNAcSO4 on LH is recognized by the ...
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#61N-acetylgalactosamine (GalNAc) [1811-31-0] - Omicron ...
Isotope pricing for high purity Carbon-13 (13C, C13) labeled and unlabeled N-acetyl-D-galactosamine (GalNAc) CAS 1811-31-0 from Omicron ...
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#62MetaCyc a 3-O-[beta-D-GalNAc-(1->4) - BioCyc
MetaCyc Protein Class: a 3-O-[β-D-GalNAc-(1→4)-β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl]-L-seryl-[protein] ...
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#63Glycoscience: Chemistry and Chemical Biology I–III
Core 1 Gal(31–3)GalNAc(0.1—O)Ser/Thr Core 2 GlcNAc(B1-6) GalNAc(o.1—O)Ser/Thr Gal(B1–3) Core 3 GlcNAc(31–3)GalNAc(o.1—O)Ser/Thr Core 4 GlcNAc(31-6) ...
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#64GalNAc - e-oligos Modifications
A similar strategy has been applied at Ionis Pharmaceuticals directed at the development of antisense oligonucleotide therapeutics (2). The GalNAc ligand ...
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#65N-乙酰-D-半乳糖胺 - 阿拉丁
阿拉丁试剂为您精选了Cas(1811-31-0)相关的许多N-乙酰-D-半乳糖胺,N-乙酰-D-半乳糖胺, D-GalNAc,,N-Acetyl-D-galactosamine,商品，你还可以按照人气、价格、销量和评价 ...
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#66N-乙酰半乳糖胺_百度百科
英文名称: N-acetylgalactosamine;GalNAc. 定义: 半乳糖上C-2位上的羟基被氨基取代后，再经乙酰化后得到的衍生物。 应用学科: 生物化学与分子生物学（一级学科），糖 ...
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#67GalNAc-asiRNA - OliX
올릭스는 미래 신약 개발의 핵심 기술인 RNA 간섭(RNAi) 기술을 바탕으로 다양한 질병에 대한 신약을 개발하는 기업입니다.
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#68Hongene Biotechで3価のGalNAc(N-アセチルガラクトサミン ...
そのため、GalNAc はASGPRを多く持つ肝細胞へ集積し、この受容体から肝細胞へ取り込まれます。GalNAcとオリゴヌクレオチドとのコンジュゲートを形成させる ...
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#69Plant Biotechnology 2002 and Beyond: Proceedings of the 10th ...
For the lepidopteran specific Cryl Ac toxin one specificity - determining group on the APN receptor has been identified as N - Acetyl Galactosamine ( GalNac ) ...
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#70N-乙酰半乳糖胺 - 百科全书
GalNAc ； 2-乙酰氨基-2-脱氧-d-半乳糖; ñ-乙酰软骨胺; 2-乙酰氨基-2-脱氧-d-吡喃半乳糖； ñ-乙酰基-d-半乳糖胺. 身份标识. CAS号 · 1811-31-0 ☒ ñ. 3D模型（杰莫尔).
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#71Glycoproteins I - 第 233 頁 - Google 圖書結果
It is possible , that when using GalNAc - R as a substrate in vitro , core 6 may arise due to Bhexosaminidase degradation of core 4 .
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#72Sphingolipid Metabolism and Cell Signaling, Part B
TABLE IV "H NMR CHEMICAL SHIFTS OF LABILE PROTONS OF GM3, GM2, GM1, GD1a, GalNAc-GD1a AND GD1b GANGLIOSIDE SPECIES" Chemical shift (ppm) of proton at ...
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#73The Glycoconjugates V2: Mammalian Glycoproteins and ...
OSM Polypeptide core UDP-GalNAc MIL . . . Prot <— GalNAc w» Prot<— GalNAc~—— SA OSM UDP-Gal Prot ~— GalNAc Prot '— GalNAc 4* SA CMP-sialic acid Gal Gal ...
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#74Glycoproteins II - 第 253 頁 - Google 圖書結果
{Neu5Gc(G2–8)},Neu5Gc(G2–6)GalNAc(al–O)Ser/Thr + [77] {Neu5Ac(q2–8)},- with 4Ac, 7Ac, 9Ac or 9Lt + [100] {Neu5Gc(q2–8)},- with 4Ac, 7Ac or 9Ac + [51,100] ...
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#76GalNAc是什么意思，N-乙酰半乳糖胺翻译 - 生物医药大词典
生物医药大词典. 让您用手机可以随时随地查单词, 背单词。 大词典 · 生物医药大词典. GalNAc. N-乙酰半乳糖胺. 相关：句子 | 文献(pubmed)
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#77Conformation of Carbohydrates - 第 176 頁 - Google 圖書結果
While o , y for Gal - 613 - GalNAc , GalNAc - B1-4 - Gal , Gal - B114 - Glc and Neu5Aca2 = 3 - Gal assigned by 2D NMR are close to those from energy ...
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#78N-乙酰-D-半乳糖胺 - 西宝生物
N-乙酰-D-半乳糖胺, N-acetyl-D-galactosamine,GalNAc, C8H15NO6, CASN: [1811-31-0], 货号：GLY141.
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#80올릭스, 'asiRNA' NASH 비임상서 “표적mRNA 억제” - 바이오 ...
올릭스는 GalNAc-asiRNA 플랫폼을 기반으로 NASH 치료제 후보물질을 개발하고 있으며 CRO(임상시험수탁기관)와 원숭이를 대상으로 OLX702A의 비임상 ...
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#81올릭스, NASH 치료제 영장류 효력시험서 표적 유전자 ... - 팜뉴스
올릭스는 GalNAc-asiRNA 플랫폼을 기반으로 한 NASH(비알코올성지방간염) 치료제 프로그램을 보유하고 있으며, CRO(임상시험수탁기관)와 원숭이를 ...
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#82N- Acetilgalactosamina
N- Acetilgalactosamina ( GalNAc ), é umderivado de amino açúcar da galactose .
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#83紧跟前沿！血脂异常新药新疗法总结 - 中国医疗
GalNAc -siRNA的结合或修饰可显著增强药物的效力。 Mipomersen（ApoB ASO 抑制剂）. 三项III 期研究和一项开放标签延长研究的 ...
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#84Galnac Transferases Market: Global Industry Trends, Share ...
The recent report on “Galnac Transferases Market Report 2022 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2030.
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#85糖転移酵素の働きと疾患との関わり - Glycoforum
GalNAc O Fuc A. GlcNAc Xyl *. Gal O Sia. GlcGICA. Man IdoA. Intracellular ... GINAC O GalNAC. マンノース○ガラクトース. △ フコース → シアル酸.
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#86Short interfering RNA therapy dramatically lowers Lp(a) in ...
The liver takes up the GalNAc and cleaves it, and there is now interfering RNA in the hepatocytes in the liver, where it combines with messenger ...
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#87O型糖鎖 - 羊土社
... が1分子結合するO-GlcNAcとは異なり，主に細胞表面や輸送小胞内，また分泌されるタンパク質にN-アセチルガラクトサミン（GalNAc）を介して数糖が結合する．
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#88올릭스, NASH 치료제 효력시험서 '표적 유전자 발현 억제' 확인
올릭스는 GalNAc-asiRNA 플랫폼을 기반으로 한 NASH(비알코올성지방간염) 치료제 프로그램을 보유하고 있으며, CRO(임상시험수탁기관)와 원숭이를 ...
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#89올릭스 영장류 시험서 NASH 치료제 효능 확인 - 한국경제
OLX702A는 올릭스의 리보핵산간섭(RNAi) 플랫폼 기술인 'GalNAc-asiRNA'을 기반으로 한다. 올릭스는 임상시험수탁기관(CRO)과 원숭이를 대상으로 ...
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#90New Trends in Antisense Oligonucleotide Therapies Market ...
Without GalNAc-conjugated and With GalNAc-conjugated. Key highlights documented in the report: Market share projections for every product ...
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#91올릭스 "NASH 치료제 영장류 효력시험서 표적 유전자 ... - MSN
올릭스는 자체 GalNAc-asiRNA 플랫폼을 기반으로 한 NASH 치료제 프로그램을 보유하고 있으며, CRO(임상시험수탁기관)와 원숭이를 대상으로 OLX702A의 ...
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#92GM1/GalNAc-GD1a complex | Neurology
Background: GM1 and GalNAc-GD1a are located on the axolemma of the motor nerves and are believed to be the antigens associated with pure motor ...
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#93Wave ALS Update Delights Industry Observers, Investors
... its alpha-1 antitrypsin deficiency program, which uses its novel GalNAc-conjugated A-to-I(G) RNA base editing oligonucleotides.
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#94Sirnaomics Doses First Subject in Phase I ... - PR Newswire
Sirnaomics to Present Latest Developments on its GalNAc-Based... Explore. More news releases in similar topics.
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#95[BioS]올릭스, 'asiRNA' NASH 비임상서 “표적mRNA 억제”
올릭스는 GalNAc-asiRNA 플랫폼을 기반으로 NASH 치료제 후보물질을 개발하고 있으며 CRO(임상시험수탁기관)와 원숭이를 대상으로 OLX702A의 비임상 ...
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#96Sirnaomics Doses First Subject in Phase I ... - PR Newswire Asia
Sirnaomics to Present Latest Developments on its GalNAc-Based Liver-Targeting Platforms and Product Pipeline at the 2022 Oligonucleotide ...
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