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#1The Farnesoid X Receptor - AHA Journals
The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids. FXR regulates bile acid synthesis, conjugation, and transport, ...
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#2Farnesoid X receptor - Wikipedia
The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor ...
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#3Farnesoid X Receptor Agonists as Therapeutic Target for ...
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, and was identified as a receptor of bile acids (BAs) (Li C. et ...
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#4Farnesoid X Receptor - an overview | ScienceDirect Topics
Farnesoid X receptor (FXR) is a nuclear hormone receptor with high expression in liver. It regulates many genes involved in lipid and glucose metabolism, liver ...
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#5Recent advances in the development of farnesoid X ... - NCBI
由 AH Ali 著作 · 2015 · 被引用 231 次 — Farnesoid X receptors (FXRs) are nuclear hormone receptors expressed in high amounts in body tissues that participate in bilirubin metabolism including the ...
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#6Farnesoid X receptor: a master regulator of hepatic triglyceride ...
由 Y Jiao 著作 · 2015 · 被引用 129 次 — Farnesoid X receptor (FXR), a member of the nuclear receptor (NR) superfamily, has been demonstrated to be the primary sensor for endogenous ...
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#7Mechanism of tissue‐specific farnesoid X receptor in ...
Abstract Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile-acid synthesis by reducing the expression ...
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#8Regulation of Carbohydrate Metabolism by the Farnesoid X ...
The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that functions as the bile acid receptor. In addition to the critical role FXR plays in ...
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#9The farnesoid X receptor and colon cancer
Farnesoid X receptor (FXR) [nuclear receptor subfamily 1, group H, member 4 (NR1H4)] is a member of the nuclear receptor superfamily of ligand-activated ...
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#10Farnesoid X receptor agonists in biliary tract disease - Lippincott
The farnesoid X receptor (FXR) is a member of ligand-activated nuclear receptor superfamily. FXR is.
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#11Nonacidic Farnesoid X Receptor Modulators - ACS Publications
The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as cellular sensor for bile acids. In this role, FXR ...
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#12Bile Acid Receptor Farnesoid X Receptor
Bile acid has been well known to serve as a hormone in regulating transcriptional activity of Farnesoid X receptor (FXR), an endogenous bile acid nuclear ...
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#13Expression and activation of the farnesoid X receptor ... - PNAS
The farnesoid X receptor/bile acid receptor (FXR) is a recently discovered member of the nuclear hormone superfamily. FXR ligands have been proposed as ...
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#14Farnesoid X Receptor Agonists Obeticholic Acid and ...
The farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in bile acid homeostasis. FXR agonists, obeticholic acid ...
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#15Microbiota-induced obesity requires farnesoid X receptor - Gut
Farnesoid X receptor (FXR) signalling alters the gut microbiota leading to modulation of glucose metabolism. (A) Principal coordinates analysis plot of ...
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#16Recent advances in the development of farnesoid X receptor ...
Abstract: Farnesoid X receptors (FXRs) are nuclear hormone receptors expressed in high amounts in body tissues that participate in bilirubin metabolism ...
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#17Targeting Farnesoid X receptor (FXR) for developing novel ...
Farnesoid X receptor (FXR) protein, also known as bile acid receptor (BAR), is one such nuclear receptor linked with various cancers. For ...
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#18Suppressing the intestinal farnesoid X receptor/sphingomyelin ...
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes.
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#19Activated-farnesoid X receptor (FXR) expressed in human ...
The farnesoid X receptor alpha (FXR or NR1H4) is a bile acid sensor, activated by binding to endogenous bile acids (BAs) (e.g., chenodeoxycholic ...
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#20Farnesoid X receptor | 1H. Liver X receptor-like receptors
FXR | HRR1 | RIP14 | Bile acid receptor | FXRα | farnesoid X activated receptor ... FXR is predominantly expressed in liver, intestine, ...
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#21Farnesoid X receptor: from medicinal chemistry to clinical ...
The farnesoid X receptor (FXR) is a bile sensor that acts in coordination with other nuclear receptors to regulate essential steps in bile ...
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#22Role of Farnesoid X Receptor in the Pathogenesis ... - Hindawi
Farnesoid X receptor (FXR) is a bile acid receptor encoded by the Nr1h4 gene. FXR plays an important role in maintaining the stability of the internal ...
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#236HL0: Crystal Structure of Farnesoid X receptor (FXR) with ...
The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired ...
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#24(PDF) Farnesoid X receptor (FXR): Structures and ligands
PDF | Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine.
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#25The identification of farnesoid X receptor modulators as ...
The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids.FXR is a validated pharmacological ...
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#26Farnesoid X Receptor Induces Murine Scavenger ... - PLOS
Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis.
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#27Farnesoid X receptor signal is involved in deoxycholic acid ...
The farnesoid X receptor (FXR) signaling pathway is known to be involved in the metabolism of bile acid, glucose and lipid.
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#28Farnesoid X Receptor Activation Promotes Hepatic Amino ...
The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, ...
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#29The Farnesoid X Receptor Controls Gene Expression in a ...
Farnesoid X receptor (FXR) is a nuclear receptor for bile acids. Ligand activated-FXR regulates transcription of genes to allow feedback ...
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#30Targeting farnesoid X receptor for liver and metabolic disorders
The farnesoid X receptor (FXR) is a metabolic nuclear receptor expressed in the liver, intestine, kidney and adipose tissue. By regulating the expression ...
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#31The Pathophysiology of Farnesoid X Receptor (FXR) in the GI ...
The Farnesoid-X Receptor, FXR, is a nuclear bile acid receptor. Its originally described function is in bile acid synthesis and regulation within the liver.
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#32The Farnesoid X Receptor Is Expressed in Breast Cancer and ...
The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression ... Cancer Res (2006) 66 (20): 10120–10126. https://doi.
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#33Bacterial metabolites directly modulate farnesoid X receptor ...
The farnesoid X receptor (FXR), a ligand-activated transcription factor belonging to the adopted orphan receptor, plays an important role in ...
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#34Farnesoid X receptor pathway (Homo sapiens) - WikiPathways
The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates ...
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#35Which medications in the drug class Farnesoid X Receptor ...
The farnesoid X receptor (FXR) is a nuclear receptor expressed in the liver, intestine, kidney, and adipose tissue that regulates a wide variety of target ...
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#36Farnesoid X Receptor activation in brain alters brown adipose ...
Background and Prupose: The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis ...
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#37Farnesoid X receptor - NR1H4 gene & protein - UniProt
Farnesoid X receptor Imported. <p>Information which has been imported from another ... Nuclear receptor subfamily 1, group H, member 4, isoform CRA_aImported.
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#38Study of the Effects of Farnesoid X Receptor (FXR) Ligands on ...
The Farnesoid X receptor (FXR) is a nuclear receptor that controls the transcription of many genes involved in lipid and glucose metabolism.
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#39Intestinal Farnesoid X Receptor and Takeda G Protein Couple ...
FXR and TGR5 are co-expressed in the ileum and colon. These 2 bile acid-activated receptors may cooperate to stimulate GLP-1 secretion and ...
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#40The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of ...
In this study, we report that activation of the farnesoid X receptor (FXR), a member of the ligand-activated nuclear receptor superfamily and ...
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#41Noncanonical farnesoid X receptor signaling inhibits ...
FXR deficiency sensitizes hepatocytes to death receptors (DRs)-engaged apoptosis. FXR overexpression, but not FXR ligands, inhibits apoptosis ...
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#42Farnesoid X Receptor Signaling Shapes the Gut Microbiota ...
The farnesoid X receptor (FXR) plays an important role in mediating the dialog between the host and gut microbiota, particularly through ...
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#43Farnesoid X Receptor Deficiency Improves Glucose ...
The farnesoid X receptor (FXR) is a key regulator of bile acid (BA) metabolism. By promoting BA efflux from the liver, inhibiting hepatic BA ...
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#44Farnesoid X receptor agonist INT-767 attenuates liver ...
Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis Ying-Bin Hu,1 ...
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#45Anti-Farnesoid X Receptor Antibody Products - Biocompare
Farnesoid X Receptor is a reported alias name for the human gene NR1H4, or 'nuclear receptor subfamily 1 group H member 4'. The 486-amino acid ...
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#46Farnesoid X receptor and fibroblast growth factor 15/19 as ...
Abstract. The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed ...
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#47Mouse Farnesoid X Receptor Reporter Assay System
Features. Screen test samples to quantify functional activity, either agonist or antagonist, that they may exert against mouse FXR; Robust technology ...
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#48How Do Farnesoid X Receptor Agonists Work? - RxList
Farnesoid X receptor (FXR) agonists are a semi-synthetic bile acid analog used to treat primary biliary cholangitis (PBC) in adult patients with inadequate ...
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#49Natural Products as Farnesoid X Receptor (FXR) Agonists
Nuclear receptors (NRs) are ligand-activated transcription factors modulating significant biological functions including cell growth, lipid metabolism, an.
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#50FXR - Intercept Pharmaceuticals
FXR, a nuclear receptor expressed in the liver and intestine, is a key regulator of bile acid, inflammatory, fibrotic and metabolic pathways. Understanding FXR.
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#51Inhibition of farnesoid X receptor signaling shows beneficial ...
In the paper titled ''Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity'' Mueller et al.
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#52Farnesoid X receptor: An important factor in blood glucose ...
Farnesoid X receptor (FXR) is a transcription factor that can be activated by bile acid as well as influenced bile acid metabolism. β-cell bile acid ...
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#53Synthesis and discovery of andrographolide derivatives as ...
Based upon the discovery of the natural compound andrographolide (1) as a non-steroidal farnesoid X receptor (FXR) antagonist, a series of andrographolide ...
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#54Farnesoid X Receptor Agonist as a new treatment option for ...
Results: One such option is using agonists of the farnesoid X receptor (FXR) which are nuclear receptors abundantly expressed in the liver and shown to play a ...
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#55FXR | Farnesoid X Receptor - Selleck Chemicals
FXR agonists are available at Selleck. Check Farnesoid X Receptor signaling reviews and assay information.
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#56Loss of functional farnesoid X receptor increases ...
The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid ...
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#57A synthetic farnesoid X receptor (FXR) agonist promotes ...
farnesoid x receptor (FXR, also referred to as NR1H4) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. Bile acids, the ...
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#58The role of farnesoid X receptor in metabolic diseases, and ...
Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic ...
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#59Transactivation and Coactivator Recruitment Assays for ...
The farnesoid X receptor (FXR) is a nuclear receptor responsible for homeostasis of bile acids, lipids, and glucose. Compounds that alter endogenous FXR ...
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#60Farnesoid X Receptor Agonism Protects against Diabetic ...
Additionally, TUDCA activates the farnesoid X receptor (FXR), which is highly expressed in tubular cells. We hypothesized that TUDCA ameliorates maladaptive ...
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#61Farnesoid X receptor agonist Treatment of hepatobiliary and ...
Tropifexor (LJN-452) is a highly potent, novel, non-bile acid farnesoid X receptor (FXR) agonist that is currently being evaluated for hepatobiliary and ...
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#62On the Evolution of Bile Salts and the Farnesoid X Receptor in ...
In particular, it has been realized that the response of the farnesoid X receptor (FXR) to bile acids provides a signal bridge between the ...
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#63Farnesoid X Receptor Agonists | DrugBank Online
A bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance ...
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#64Impaired Intestinal Farnesoid X Receptor Signaling in Cystic ...
Background & Aims. The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the ...
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#65Farnesoid x receptor (fxr) and intestinal mucosa - Slideshare
Bile acids activated receptors regulate the integrity of gastrointestinal mucosa focus on FXR. Stefano Fiorucci, MD Department of Surgical and Biomedical ...
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#66New key publication:Intestinal Farnesoid X Receptor Controls ...
Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. PX20606 (PX) activates FXR in the intestine, ...
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#67Nuclear receptors as never seen before: LXR (LIVER X ...
Liver X receptors (LXRs) are ligand-dependent transcription factors that regulate gene expression of genes that play a crucial role in the ...
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#68Targeting Farnesoid X receptor with Obeticholic acid - DocMode
An online lecture on Targeting Farnesoid X receptor with Obeticholic acid : Hype or Hope on DocMode. An online Lecture on Hepatology.
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#69Carroceria; LOGO GILERA RUNN FX/FXR PVGRI. SHOP ...
This free Logos design of fxr Logo EPS has been published by PNGLogos. ... 'Farnesoid X receptor' is one option -- get in to view more @ The Web's largest ...
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#70Lipid Signaling and Metabolism - 第 424 頁 - Google 圖書結果
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid ... Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) ...
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#71Diabetes: Advances in Research and Treatment: 2011 Edition
“Our previous studies have shown that the farnesoid X receptor (FXR), a bile acid-activated nuclear hormone receptor, modulates renal SREBP-l expression.
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#72Signaling Pathways in Liver Diseases - 第 397 頁 - Google 圖書結果
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and ... Farnesoid X‐receptor activates transcription of the phospholipid pump MDR3.
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#73Successful Drug Discovery, Volume 3 - 第 241 頁 - Google 圖書結果
113 Mencarelli, A., Renga, B., Distrutti, E., and Fiorucci, S. (2009) Antiatherosclerotic effect of farnesoid X receptor. Am. J. Physiol. Heart Circ.
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#74Non-Alcoholic Fatty Liver Disease: A 360-degree Overview
Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today. 2012;17:988–97. 37.
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#75Nuclear Receptors: Current Concepts and Future Challenges
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. ... Natural structural variants of the nuclear receptor farnesoid X receptor affect ...
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#76Molecular signatures of long-term hepatocellular carcinoma ...
... receptor signaling, for example, the farnesoid X receptor (FXR) pathway, were down-regulated in association with high-risk PLS-NAFLD.
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#77Terns Pharmaceuticals Highlights Clinical Data from Multiple ...
Data are also being presented from the Phase 2a LIFT study of TERN-101, the Company's liver-distributed farnesoid X receptor (FXR) agonist.
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#78Gilead to Present Latest Data From Across Liver Disease ...
Safety and Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor in a Proof-of-Concept Study in Patients With Compensated Cirrhosis ...
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#79Terns Pharmaceuticals Highlights Clinical Data ... - StreetInsider
... “Multiple doses of thyroid hormone receptor-beta agonist TERN-501 ... Company's liver-distributed farnesoid X receptor (FXR) agonist.
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#802022-06-22 | NDAQ:TERN | Press Release - Stockhouse
Data are also being presented from the Phase 2a LIFT study of TERN-101, the Company's liver-distributed farnesoid X receptor (FXR) agonist.
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#81Search: authors:"Xu, H. Eric" - Paperity
Receptor binding studies show that the Omicron BA.2 spike trimer exhibits ... The bile acid (BA)-sensing nuclear receptor, farnesoid X receptor (FXR), ...
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#82PPAR-alpha agonist treatment increases trefoil factor family-3 ...
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflamma- tory response. Hepatology 2008; 48: 1632-43. 11. De Bosscher K, Haegeman G.
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#83Receptor X farnesoide FunciónyInteracciones
El receptor de ácidos biliares ( BAR ), también conocido como receptor farnesoide X ( FXR ) o NR1H4 (subfamilia 1 del receptor nuclear, grupo H, miembro 4), ...
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#84Cellular Signaling in Health and Disease - 第 97 頁 - Google 圖書結果
Receptors,. and. Farnesoid. X. Receptors. Regulate. Transcription ... operate together with the liver X receptors (LXRs) and farnesoid X receptor (FXR) to ...
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#85Virtual Drug Design - 第 197 頁 - Google 圖書結果
against FXR exhibited partially similar binding interactions to those of the ... Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and ...
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#86Cureus | Coevolution of the Human Host and Gut Microbiome
... acid membrane receptors, in particular, nuclear farnesoid-activated X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), ...
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#87Intercept Announces PBC Data Presentations at The
OCALIVA, a farnesoid X receptor (FXR) agonist, is indicated for the treatment of adult patients with primary biliary cholangitis (PBC).
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#88The Liver: Biology and Pathobiology - 第 375 頁 - Google 圖書結果
Farnesoid X receptor activation promotes hepatic amino acid catabolism and ammonium clearance in mice. Gastroenterol, 2017;152:1462–76. 13.
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#89Intercept Announces PBC Data P - GuruFocus.com
OCALIVA, a farnesoid X receptor (FXR) agonist, is indicated for the treatment of adult patients with primary biliary cholangitis (PBC).
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#90Clinical and Population Studies - CiteSeerX
tional low-density lipoprotein receptor (LDLR) alleles have ... such as the estrogen and farnesoid X receptors, transforming.
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#91無題
Although all act via insect nicotinic acetylcholine receptors, ... farnesoid X receptor (FXR AMG-410 serves as a proof-of-concept that NMR-guided drug ...
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#92Pharmacological Control Of Lipid Metabolism Copy - staging
receptor (FXR). However, farnesol's effects on human hepatic lipid metabolism are currently unknown. The objective of this study is to ...
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#93The Biliary System, Second Edition - SoftArchive – SANET
... and the farnesoid X receptor (FXR) pathways, respectively. ... by rapidly activating nuclear receptors and cell signaling pathways.
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