雖然這篇5-azacytidine鄉民發文沒有被收入到精華區：在5-azacytidine這個話題中，我們另外找到其它相關的精選爆讚文章
[爆卦]5-azacytidine是什麼？優點缺點精華區懶人包
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#1Azacitidine - Wikipedia
Azacitidine, sold under the brand name Vidaza among others, is a medication used for the treatment of myelodysplastic syndrome, myeloid leukemia, and juvenile ...
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#25-Azacytidine and 5-aza-2′-deoxycytidine as ... - Nature
5 -Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide range of anti-metabolic activities when tested ...
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#35-Azacytidine = 98 HPLC 320-67-2 - Sigma-Aldrich
5 -Azacytidine (4-Amino-1-(β -D-ribofuranosyl)-1,3,5-triazin-2(1H)-one ); ≥ 98% HPLC; 5-Azacytidine is a chemical analog of cytidine; Potent growth ...
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#45-Azacytidine | Epigenetic Modifier - STEMCELL Technologies
5 -Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity.
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#55-Azacytidine (Azacitidine) | DNMT Inhibitor - MedChemExpress
5 -Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated ...
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#65-Azacytidine/Azacitidine - PubMed
5 -Azacytidine is a pyrimidine nucleoside analog that has been discovered more than 40 years ago. Despite remarkable responses in the treatment of acute ...
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#7Azacitidine (5-Azacytidine) | 99.92%(HPLC) - Selleck Chemicals
Azacitidine(Vidaza)and its deoxy derivative, decitabine (5-aza-2′deoxycytidine), are used in the treatment of myelodysplastic syndrome.
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#85-Azacytidine - Cayman Chemical
5 -Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic ...
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#95-Azacytidine - an overview | ScienceDirect Topics
5 -Azacytidine (azacitidine) incorporates into DNA or RNA and irreversibly binds methyltransferase, and is a useful chemotherapeutic for myelodysplastic ...
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#105-Azacytidine | CAS 320-67-2 | SCBT
5 -Azacytidine is a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (Dnmt), ...
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#115-Azacytidine (CAS 320-67-2) - R&D Systems
5 -Azacytidine is a DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity.
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#12HY-10586-200mg | 5-Azacytidine [320-67-2] Quimigen
5 -Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA ...
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#135-Azacytidine #50646 - Cell Signaling Technology
5 -Azacytidine is a nucleoside analogue of cytidine and a DNA methyltransferase inhibitor. 5-Azacytidine is incorporated into DNA to covalently trap DNA ...
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#145-Azacytidine a DNA methyltransferase (DNMT) Inhibitor
Active Motif offers research kits, assays and biocomputing systems that help researchers study the function, regulation and interactions between genes, ...
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#155-Azacytidine Supplier | CAS 320-67-2 - Tocris Bioscience
5 -Azacytidine is a DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity.
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#16Definition of azacitidine - NCI Drug Dictionary
Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by ... US brand name: Onureg Vidaza. Abbreviation: 5-AC 5-AZC AZA-CR.
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#175-Azacytidine Potentiates Anti-tumor Immunity in a Model ...
In vitro treatment of mouse and human PDAC cell lines with the DNA methyltransferase inhibitor 5-azacytidine (Aza) resulted in augmented ...
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#185-Azacytidine - DNA Methyltransferase - APExBIO
5 -Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent ...
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#19探討5-Azacytidine對於皮膚移植物存活時間與抑制bleomycin ...
5 -Azacytidine（5-Aza）具有抗腫瘤與抑制DNA甲基化轉移酶的作用，作用機制與5-Aza直接嵌入DNA與RNA的結構中，分別抑制DNA甲基化與干擾mRNA形成與轉譯蛋白質有關。
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#20Treatment with 5-azacytidine induces a sustained response in ...
Treatment with 5-azacytidine induces a sustained response in patients with angioimmunoblastic T-cell lymphoma ... Blood (2018) 132 (21): 2305–2309 ...
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#21Effect of 5-azacytidine (5-aza) on UCP2 expression in human ...
In this study, the hepatocellular carcinoma Hep3B and HepG2 cells and colorectal cancer HT-29 cells were treated with 5-azacytidine (5-aza), ...
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#22Equitoxic Doses of 5-Azacytidine and 5-Aza-2 - PLOS
The hypomethylating agent 5-Azacytidine (5-Aza-CR) is the first drug to prolong overall survival in patients with myelodysplastic syndrome (MDS).
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#23A Phase I Study of 5-Azacytidine in Combination With ...
This is a phase I clinical study with expansion phase, using hypomethylating agent, 5-azacytidine (AZA), in sequential with chemotherapy to evaluate whether ...
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#24The Hedgehog pathway as targetable vulnerability with 5 ...
An RNAi silencing screen of 270 genes from the CDRs of chromosomes 5 and 7 was performed in combination with 5-Aza treatment in four AML cell ...
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#25Combination of 5-azacytidine (5-AZA) and valproic acid (VPA ...
3547 Background: 5-AZA is a DNA hypomethylating agent. VPA is a histone deacetylase inhibitor (HDACI). The combination of hypomethylating agents and HDACI ...
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#265-Azacytidine delivered by mesoporous silica nanoparticles ...
5 -Azacytidine delivered by mesoporous silica nanoparticles regulates the differentiation of P19 cells into cardiomyocytes. Check for updates.
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#275-阿扎胞苷5-Azacytidine - 中昊生物官网
5 -Azacytidine 诱导细胞自噬(autophagy)。 ◇DNA Methyltransferase inhibitor. ◇Blocks cell cycle progression at G1. ◇Induces activation of HIV-1 promoter.
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#285-Azacytidine (3842) - Bio-Techne
View and buy high purity 5-Azacytidine from Tocris Bioscience, a Bio-Techne brand. DNA methyltransferase inhibitor. Cited in 5 publications.
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#295-Azacytidine - Cell Guidance Systems
5 -Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (DNMT), forming covalent adducts with cellular DNMT1 depleting enzyme ...
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#305-Azacytidine - Arbor Assays
5 -Azacytidine · Features DNA Methyltransferase inhibitor · Blocks cell cycle progression at G1 · Induces activation of HIV-1 promoter · Description. Incorporates ...
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#31azacitidine | Ligand page
The IUPHAR/BPS Guide to Pharmacology. azacitidine ligand page. ... Synonyms: 5-AZAC | 5-azacytidine | ladakamycin | Onureg® | Onureg® (CC-486; ...
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#32Drug: 5-azacytidine - Cancerrxgene
Cell line TCGA classification Tissue Tissue sub‑type IC50 AUC P32‑ISH UNCLASSIFIED blood Burkitt_lymphoma 0.358027 0.417980 SU‑DHL‑5 DLBC blood B_cell_lymphoma 0.404273 0.435339 JiyoyeP‑2003 UNCLASSIFIED blood Burkitt_lymphoma 0.549226 0.480941
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#33320-67-2 | 5-Azacytidine - Toronto Research Chemicals
Catalogue Number, A796000. Chemical Name, 5-Azacytidine. Synonyms, Azacitidine; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5-AC; 5-AZC; 5-AZCR; ...
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#34P1.01-05 Phase I Study of Inhaled 5-Azacytidine (5-Aza) in ...
P1.01-05 Phase I Study of Inhaled 5-Azacytidine (5-Aza) in Patients (Pts) with Advanced Non-Small Cell Lung Cancer (NSCLC) · Background · Method · Result.
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#355-Azacytidine | CAS# 320-67-2 | 1854 | BioVision, Inc.
5 -Azacytidine is a potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, ...
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#365-Azacytidine, DNMT1 inhibitor (ab142744) - Abcam
Product name. 5-Azacytidine, DNMT1 inhibitor · Description. Potent DNMT1 inhibitor. Induces DNA hypomethylation. · Alternative names. 5-AzadCyD; Dacogen; NSC ...
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#37CHEBI:2038 - 5-azacytidine - EMBL-EBI
ChEBI Name, 5-azacytidine. ChEBI ID, CHEBI:2038. Definition, An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one ...
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#385-Azacytidine, 99% - Thermo Fisher Scientific
5 -Azacytidine, 320-67-2, is an antineoplastic nucleoside analog which acts as an epigenetic modifier through inhibition of DNA methyltransferase.
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#395-Aza-2'-deoxycytidine - ALX-480-096 - Enzo Life Sciences
5 -Aza-2'-deoxycytidine ... Inhibitor of DNA methyltransferase. Restores mRNA and protein expression of caspase-8 and TRAIL (tumor necrosis factor-related ...
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#405-Azacytidine - HiMedia Laboratories
Copyright @ 2023 HiMedia Laboratories. All Rights Reserved. Reproduction of any materials from the site is strictly prohibited.
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#415-Azacytidine in the Treatment of Intermediate-2 and High-risk ...
5 -Azacytidine is a chemical analog of cytidine and acts as a hypomethylating agent. DNA methylation is a process utilized in vivo to silence and regulate gene ...
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#425-Azacytidine, 98%, Thermo Scientific Chemicals
Causes DNA demethylation or hemi-demethylation; a powerful mutagen Shop 5-Azacytidine, 98%, Thermo Scientific Chemicals at Fishersci.com.
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#43US7858774B2 - Synthesis of 5-azacytidine - Google Patents
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the ...
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#445-Azacytidine | CAS:320-67-2 - BioCrick
5 -Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated ...
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#455-Azacytidine enhances efficacy of multiple chemotherapy ...
5 -Azacytidine enhances efficacy of multiple chemotherapy drugs in AML and lung cancer with modulation of CpG methylation. Authors:.
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#465-Azacitidine - Vidaza®, Onureg - Chemocare
5 -Azacitidine ... Azacitadine is the generic name for the trade name drugs Vidaza or Onureg. In some cases, health care professionals may use trade name or the ...
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#475-Azacytidine, a DNA methyltransferase inhibitor, induces ...
In this study, we investigated the cytotoxicity of 5-azacytidine, a DNA methyltransferase inhibitor, against multiple myeloma (MM) cells, and characterized ...
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#48Azacitidine: Uses, Interactions, Mechanism of Action - DrugBank
Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine may induce antineoplastic activity by ...
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#495-Azacytidine 320-67-2 - SRL Chemical
34476. 5-Azacytidine extrapure, 98%. 320-67-2. Molecular Formula : C8H12N4O5 Molecular Weight : 244.21. Part B Storage : -20 °C (Blue/Dry Ice)
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#50Effect of 5'-fluoro-2'-deoxycytidine, 5-azacytidine, and 5-aza-2 ...
The colon cancer HCT-116 cell line was treated with 5-azaC, 5-Aza-CdR, and FdCyd at 24 and 48h. To determine colon cancer HCT-116 cell viability, cell apoptosis ...
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#515-Azacytidine prevents relapse and produces long ... - PNAS
5 -Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox.
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#52Plasma and cerebrospinal fluid pharmacokinetics of the DNA ...
5 -Azacytidine (5-AZA), a potent DNA methyltransferase inhibitor and cytotoxic agent approved for myelodysplastic syndrome and acute myeloid leukemia, 1 has ...
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#53Azacitidine (5-Azacytidine) | ≥99%(HPLC) | Selleck
Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA ...
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#54The effects of 5-azacytidine on the function and number of ...
5 -azacytidine (5-azaC) not only prolongs the survival of patients with intermediate 2 and high-risk myelodysplastic syndrome (MDS),1,2 but ...
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#555-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 | 189825
5 -Aza-2ʹ-Deoxycytidine, CAS 2353-33-5, is a cytosine analog that acts as a suicide substrate and inhibits DNA methyltransferase activity. · SDS · CoA · References ...
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#56Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2
Epigenetic drugs, such as 2′-deoxy-5-azacytidine (DAC), are able to cause reactive expression of tumor suppressor genes (TSG) in human cancers ...
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#57The effect of 5-azacytidine and cytidine analogs onDrosophila ...
The compound 5-azacytidine, when added to primary cell cultures, inhibited normal differentiation at subtoxic doses while inducing the production of three ...
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#585-Azacytidine: A Promoter of Epigenetic Changes in the Quest ...
DNA methylation levels can be modified through the use of drugs such as 5-Azacytidine (5-AzaC), an inhibitor of DNA methylation, which has been used during ...
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#595-Azacytidine and 5-aza-2′-deoxycytidine ... - ResearchGate
5 -Azacytidine (5-Az), a DNA demethylation agent, is a nucleotide analog that is used as a DNA methyltransferase inhibitor. 5-Az can selectively ...
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#60A case report of a very late response to 5-azacytidine in a...
The hypomethylating agent 5-azacytidine has been approved in Europe for patients with intermediate 2 and high (i.e., higher) risk myelodysplastic syndrome ...
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#61Resistance to decitabine and 5-azacytidine emerges ... - bioRxiv
Pyrimidine metabolism is a network that senses and preserves nucleotide balances: Decitabine, a deoxycytidine analog, and 5-azacytidine, ...
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#625-Azacytidine Can Induce Lethal Mutagenesis in Human ...
Incorporation of 5-aza-2′-deoxycytidine-5′-triphosphate into DNA. ... 5-Azacytidine and 5-azadeoxycytidine inhibit human immunodeficiency virus type 1 ...
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#635-azacytidine reduces methylation, promotes differentiation ...
5 -azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.
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#645-AZACYTIDINE | CAMEO Chemicals | NOAA
5 -AZACYTIDINE. Chemical Identifiers | Hazards | Response Recommendations | Physical Properties | Regulatory Information | Alternate Chemical Names. Chemical ...
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#655-Aza-dCTP, Nucleotides for Application in Epigenetics
5 -Aza-dCTP is a inhibitor of DNA methylation and an antileukemic agent. It has been used to reactivate silent tumor suppressor genes. Specific Ligands:.
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#66Modes of action of the DNA methyltransferase inhibitors ...
Abstract The cytosine analogues 5-azacytosine (azacytidine) and 2′-deoxy-5-azacytidine (decitabine) are the currently most advanced drugs ...
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#67Azacitidine and Venetoclax in Previously Untreated Acute ...
Eastern Cooperative Oncology Group (ECOG) performance-status scores range from 0 to 5, with 0 indicating no symptoms and higher scores ...
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#685-Azacytidine Promotes an Inhibitory T-Cell Phenotype and ...
Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid malignancies. 5-Aza enhances anticancer immunity, ...
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#69A pharmacodynamic study of 5-azacytidine in the P39 cell line
5 -azacytidine (azacytidine), a DNA hypomethylating agent, was recently approved as the first therapeutic agent for the treatment of myelodysplastic ...
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#70Encyclopedia of Cancer - 第 282 頁 - Google 圖書結果
5 -Azacytidine represents an analogue of the cytosine nucleoside. It is incorporated into the DNA during replication. Inclusion of 5-azacytidine inhibits DNA ...
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#71Cancer Treatment Reports
Effect of 5 - azacytidine on differentiation and DNA methylation in ... The tumorigenicity of 5azacytidine in the male Fischer rat .
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#72Prolonging CART Cell Persistence Using Conditioning with 5 ...
Pre-treatment with the single dose of demethylating agent 5-azacytidine (AZA) delayed CART cell death in co-cultures with large numbers of target cells and ...
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#73Mechanisms of Differentiation - 第 2 卷 - 第 112 頁 - Google 圖書結果
106 We have isolated an unstable , multipotential derivative of 10T / 2 cells after 5 - aza - CR treatment which can form muscle , fat , and cartilage at a ...
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#745-azacytidine treatment reorganizes genomic histone ...
Key words: DNA methylation, 5-azacytidine, ChIP-chip, cancer cells, H3K27me3, H3K9me3, transcriptional repression.
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#75Azacitidine (Vidaza, Onureg) - Cancer Research UK
Your healthcare team can let you know your treatment plan. This is an example of having azacitidine as an injection: Day 1 to day 5. You have azacitidine as an ...
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#76deoxycytidine and deacetylase inhibitors reactivates HIV‐1
Two well-characterized nucleoside analog DNA methylation inhibitors, 5-azacytidine (5-AzaC, marketed as Vidaza) and 5-aza-2′-deoxycytidine ...
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#77Cancer Chemotherapy Reports
With 5azacytidine , it is somewhat more difficult to state unequivocally that this ... pathways involved in 5 - azacytidine metabolism is shown in figure 2.
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#785-Azacytidine, >=98% (HPLC) | A2385-100MG
5 -Azacytidine has been used:for cell inductionto study its effects on bovine fetal mesenchymal stem cells (bfMSC)to study its effects on human bone marrow ...
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#79Biology Bulletin of the Academy of Sciences of the USSR.
INCREASING THE PROTEIN CONTENT OF WHEAT GRAIN UNDER THE INFLUENCE OF 5 - AZACYTIDINE , A DNA METHYLATION INHIBITOR UDC 547.963.3 : 577.112 B. F. Vanyushin ...
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#80effects of 5-azacytidine on transformation and gene expression
Key words: 5-azacytidine; gene expression; transformation; Nicotiana tabacum; protoplast; NPT II. INTRODUCTION. Nuclear DNA is often heavily methylated; ...
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#81Acute myeloid leukaemia azacitidine - eviQ
... cancer units and alternative scheduling may be used i.e. azacitidine for 5 days, followed by 2 day weekend break, followed by azacitidine for 2 days.,.
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#82pharmacokinetic-pharmacodynamic studies of 5-azacytidine in
5 -Azacytidine and decitabine are hypomethylating agents that induce DNA demethylation, resulting in reactivation of hypermethylation-.
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#83Childhood Leukemia: A Practical Handbook
There are two DNMTi in clinical use: 5-azacytidine and 5-aza-2¢-deoxycytidine (decitabine). Both are nucleoside analogues that were originally investigated ...
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#845-azacytidine, a chemotherapeutic drug, induces ... - Agris (FAO)
5 -azacytidine (5AzC) is a cytidine analogue with two main effects on cellular conditions; DNA damage, resulting in apoptosis, and DNA hypomethylation, ...
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#856-Methyl-5-azacytidine | Cas# 105330-94-7 - GlpBio
6-Methyl-5-azacytidine is a potent DNMT inhibitor.
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#86Biological Effects of 5-Azacytidine in Eukaryotes - Abstract
Keywords: 5-AzacytidineMetabolic transformationsIncorporationEffects on DNA and RNAModulation of liver regenerationImpaired gastric ...
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#875-Azacytidine treatment determines the epigenetic ... - Labroots
5 -Aza effects upon A549 cell viability and cell cycle. References. •Global cancer statistics, 2018. https://gco.iarc.fr/ (accessed on 9 March 2021).
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#88Paper: Mechanisms of Resistance to 5-Azacytidine/Decitabine ...
678 Mechanisms of Resistance to 5-Azacytidine/Decitabine in MDS-AML and Pre-Clinical In Vivo Proof of Principle of Rational Solutions to ...
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#89Report of the Division of Cancer Treatment, NCI.
L.I. Synthesis of l - glycosyl derivative of 5 - azauracil and 5 - azacytidine . Coll . Czech . Chem . Commun . 29 : 2060-2076 , 1964 2 .
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#90Cumulated Index Medicus
Lindsey JD , et al . stimulated by 5 - azacytidine pretreatment . Cihák A , et al . pancreas . McGuinness EE , et al . Scand J Gastroenterol Brain Res 1981 ...
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#91Maintenance venetoclax and 5-azacytidine in patients with AML
Remission from AML is successful with current therapies, but relapse rates remain high among patients. Alexandre Bazinet, MD, McGill ...
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#92Molecular characterization of regenerated cardiomyocytes ...
Stromal cells were immortalized, exposed to 5-azacytidine, and repeatedly screened for spontaneously beating cells. CMG cells began to beat spontaneously ...
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#93Experimental Evaluation of Antitumor Drugs in the USA and ...
5 - Fluorouracil Bosch and associates ( 35 ) in a report on various biochemical ... Levitan and Webb ( 45 ) reported that 5 - azacytidine also caused a ...
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#94PARP Inhibitor I, 3-ABA - Merck
ethanol: 1 mg/mL water: 1 mg/mL. DMSO: 5 mg/mL. shipped in. ambient. storage temp. 10-30°C. InChI. 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10) ...
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#95Magrolimab + Azacitidine vs Venetoclax Acute Myeloid ...
And we basically showed that the combination of Azacitidine Magrolimab (Hu5F9-G4) in ... subsets that have been presented has been between 5 and 7 months.
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#96exercise | Lab Land
5 -azacytidine · atherosclerosis · blood flow · cardiology · decitabine · diet · DNA methylation · epigenetics · exercise · fluid dynamics · Georgia Tech ...
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#97Lymphoma Committee - SWOG
CC-486 (Oral Azacytidine) in Participants Age 75 Years or Older with Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIB.
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#98KAHR Reports Dose Escalation Results from Phase I ... - ABC27
DSP107 is also being tested in combination with standard of care therapies (azacytidine and azacytidine with venetoclax) for ...
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#99White fibrous tissue in urine
... with human platelet lysate and 5-azacytidine Mar 13, 2018 · Fibrous connective tissue contains fibroblast cells and is made up of fibrous fibers.