Chef Carlo’s Grissini and foie gras pate with Shao Xing wine

Chef Carlo’s Grissini
Bread flour 500 g
Salt 10 g
Sugar 5 g
Water 175g
Butter 125 g , soft , RT
Egg 1 , beat
Yeast 15 g , dry yeast is fine.

Add any herbs if like, or brush with olive oil and roll in Parmesan cheese. Sesame seeds.

1. In a Kitchen Aid bowl,add everything, mix, then beat with hook untill elastic.
2. Fold into a book size. Put on tray and baking paper, with Semolina on top n bottom. cover with wet towel, proof for 1 hour.
3. Preheat oven to 180C
4. Cut the dough into thin long sticks, stretch gently and keep the air in. Shape like a chopstick. Bake for 15 to 20 mins . Cool.
#baking #bread #Boulangerie #pate #foiegras #canapés #chefcoco #lecordonbleu #下酒菜

Chef Carlo’s Grissini and foie gras pate with Shao Xing wine

Chef Carlo’s Grissini
Bread flour 500 g
Salt 10 g
Sugar 5 g
Water 175g
Butter 125 g , soft , RT
Egg 1 , beat
Yeast 15 g , dry yeast is fine.

Add any herbs if like, or brush with olive oil and roll in Parmesan cheese. Sesame seeds.

1. In a Kitchen Aid bowl,add everything, mix, then beat with hook untill elastic.
2. Fold into a book size. Put on tray and baking paper, with Semolina on top n bottom. cover with wet towel, proof for 1 hour.
3. Preheat oven to 180C
4. Cut the dough into thin long sticks, stretch gently and keep the air in. Shape like a chopstick. Bake for 15 to 20 mins . Cool.
#baking #bread #Boulangerie #pate #foiegras #canapés #chefcoco #lecordonbleu #下酒菜

看過一些數據，一年中死於化療的數字比本身癌症還多。

【美國終於承認手術或化療後癌細胞反而加速擴散】 - 路透社報道

科學家一項最近研究發現，有些癌症患者在接受手術、化療或放療後，癌細胞反而加速擴散，造成這種現象的原因之一是人體一種名為TGF-be-ta物質。因此，控制TGF-be-ta物質在人體內的含量，才是治癒癌症的關鍵。

來自美國田納西州範德比爾特大學的研究人員在老鼠身上試驗發現，患有乳腺癌的老鼠在服用化療物質“阿黴素”或接受放療後，體內的TGF-be-ta物質含量提高，刺激癌細胞向肺部轉移。而使用某種抗體抑制它們體內的TGF-be-ta含量則能夠遏制癌細胞擴散。

參考連結：Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838926/

此前有科學家提出，動物體內的原發性腫瘤可能會抑制其他腫瘤生長，但一旦原發性腫瘤被從體內清除，其他被抑制腫瘤可能會就此瘋長。而科學此次研究顯示，TGF-be-ta就是這樣一種既能抑制腫瘤生長，也能刺激癌細胞擴散的物質。

主持研究的卡洛斯.。啊特亞加博士補充說，可能還有其他物質與TGF-be-ta一樣對癌症的治療有類此的影響。他們希望通過對TGF-be-ta的研究得出更多結論。 以上訊息在10月8日的《參考訊息》報也有報導。

看來主張手術或放化療治療癌症的人，良心終於被發現了。 人類自從3000年前發明瞭藥物以來，200年前發現了抗生素，人類的疾病就更複雜，更多，更難治。

很多慢性病，免疫系統紊亂症，都與藥物和抗生素的濫用有很大的關係。人的耐藥性越強。人就更難戰勝病魔。而癌症自然也有它的天敵。眾所周知醫學界對癌症束手無策。

醫學界奪命奪錢三招“手術、化療、放療”。目前醫學科技很發達，世界各國投入無數財力物力去研究醫學，但是卻對絕大多數的慢性疾病無能為力，這不能不說是個人類天大的笑話。

1、成年人每人每天都有3000-6000個癌細胞產生（由於基因突變而讓正常細胞變成癌細胞，基因突變原因很多，化學藥物，肉類，動物荷爾蒙、空氣汙染等等）。

２、但人每一天誕生的癌細胞幾乎都被人體自身自然殺手細胞（NK細胞）殺滅了。所以不是人人都會患上癌症.當免疫系統下降，也就是自然殺手細胞弱了，癌細胞就佔上風。久而久之5-10年以上就會得到癌症.如果我們能讓癌症病人身體裡的自然殺手細胞變強，恢復活力，對付癌症是簡單的事。

所以癌症病人只能靠自己也就是自身免疫細胞－自然殺手細胞（NK細胞）來對付癌症。
　　
３、讓自然殺手細胞（NK細胞）恢復活力的唯一途徑是營養70%、心情10%、運動10%、休息10%（世界衛生組織的健康的四大基石）。

４、只要有充足的營養,自然細胞就能恢復到以前的活力來殺滅癌細胞。（這個世界一物降一物，但一物應該是人體的細胞而不是藥物，也不是植物，更不是動物。人的免疫細胞是可以對付世界上所有的病毒和細菌，比如非典病毒，艾滋病毒，埃博拉病毒，流感病毒，關鍵是人的免疫細胞要足夠的強。例外：但人的免疫細胞沒有辦法對付毒藥。

５、醫學上常規不得已用藥物和化療、放療、電療方法，除了把癌細胞部分殺滅外，反而把正常的大量的自然殺手細胞殺滅.醫學界奪命奪錢三招“手術、化療、放療”！所以手術藥物和化療放療有時能減輕病人的痛苦同時反而加速癌症病人的死亡.

６、為什麼國內的癌症研究者都是研究藥物如何殺滅癌細胞（治標）。為什麼不能研究讓人體內的自然殺手細胞增強來殺滅癌細胞呢（治本）?只有0.5%的經過化療放療的病人能活過超過5年！！

７、世界上最好的醫生是自己的免疫系統、免疫細胞，而不是醫生和藥物！！只有本人的免疫系統（自然殺手免疫細胞）才能殺滅癌細胞。可是藥物和化放療卻會快速讓人的免疫系統下降。

８、請癌症病人去新華書店購買《營養免疫學》陳昭妃癌症研究博士著，《不要讓不懂營養學的醫生殺了你》雷.D.斯全德醫學博士著。《別讓醫生殺了你》, 《食物是最好的醫生》,《醫生對你隱瞞了什麼》...等最新學科書籍。但是闡述得最完整最好的還是《營養免疫學》這本書。
　　
９ 四大基石裡的休息和運動促使免疫力提高。晚上安靜下來睡覺的時候，是人體內免疫細胞正在大量修復身體破損的細胞的時候，所以晚上也是最需要休息和營養的時候。
　　
１０、偶然我們在報上看到有些極少數癌症病人得了癌症不治,反而過了幾年後身體的癌症症狀全無,經檢測沒有癌細胞的存在.這是因為這個癌症病人平常的飲食心情運動休息讓體內的自然殺手細胞得到增強來殺滅癌細胞.也就是自愈力了——自已治病的能力。治癌不能靠高科技，而只能靠自然的力量、自身的力量。

Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

Abstract
We investigated whether TGF-β induced by anticancer therapies accelerates tumor progression. Using the MMTV/PyVmT transgenic model of metastatic breast cancer, we show that administration of ionizing radiation or doxorubicin caused increased circulating levels of TGF-β1 as well as increased circulating tumor cells and lung metastases. These effects were abrogated by administration of a neutralizing pan–TGF-β antibody. Circulating polyomavirus middle T antigen–expressing tumor cells did not grow ex vivo in the presence of the TGF-β antibody, suggesting autocrine TGF-β is a survival signal in these cells. Radiation failed to enhance lung metastases in mice bearing tumors that lack the type II TGF-β receptor, suggesting that the increase in metastases was due, at least in part, to a direct effect of TGF-β on the cancer cells. These data implicate TGF-β induced by anticancer therapy as a prometastatic signal in tumor cells and provide a rationale for the simultaneous use of these therapies in combination with TGF-β inhibitors.

Go to:
Introduction
TGF-β is both a tumor suppressor and a tumor promoter. The TGF-β ligands bind to cognate serine/threonine kinase transmembrane receptors, which in turn phosphorylate and activate the Smad family of signal transducers. Once activated, Smad2 and Smad3 associate with Smad4 and translocate to the nucleus, where they regulate the transcription of genes involved in cell cycle arrest and apoptosis (1), essential for the tumor suppressor role of the TGF-βs. Indeed, loss or attenuation of TGF-β signaling in epithelial cells and stroma is permissive for epithelial cell transformation (2, 3). On the other hand, introduction of dominant-negative TGF-β receptors into metastatic cancer cells has been shown to inhibit epithelial-to-mesenchymal transdifferentiation, motility, invasiveness, and survival, supporting the tumor promoter role in TGF-β in fully transformed cells (reviewed in ref. 4). Most carcinomas retain TGF-β receptors but attenuate or lose the Smad-dependent antimitogenic effect while, in some cases, gaining prometastatic abilities in response to TGF-β. In addition, excess production and/or activation of TGF-β by cancer cells can contribute to tumor progression by paracrine mechanisms involving modulation of the tumor microenvironment (2, 5, 6). These data have provided a rationale in favor of blockade of autocrine/paracrine TGF-β signaling in human cancers with a therapeutic intent.

In addition to Smads, TGF-β can stimulate several transforming signaling pathways (7). TGF-β has previously been shown to protect transformed cells from apoptosis (8–10). One possible mechanism for this cellular response is TGF-β–induced activation of PI3K and its target, the serine-threonine kinase Akt (11, 12), a signaling program associated with resistance to anticancer drugs. Some tumors resistant to conventional anticancer chemotherapy overexpress TGF-βs (13, 14), and inhibitors of TGF-β have been shown to reverse this resistance (15). In addition, overexpression of TGF-β ligands have been reported in most cancers, and high levels of these in tumor tissues and/or serum are associated with early metastatic recurrences and/or poor patient outcome (16–21).

In transgenic models of breast cancer, TGF-β signaling enhances the metastatic progression of established mammary tumors induced by oncogenes such as Neu/ErbB2 or polyomavirus middle T antigen (PyVmT) (22–24). Furthermore, in transgenic mice expressing the PyVmT oncogene under the control of the MMTV/LTR mammary promoter, conditional induction of active TGF-β1 for as little as 2 weeks increases lung metastases by more than 10-fold (10). Some anticancer therapies have been shown to induce TGF-β systemically or in situ (25–28). Therefore, we speculated that in tumors resistant to anticancer therapies or in resistant subpopulations within those tumors, treatment-induced TGF-β would provide a survival signal to cancer cells potentially accelerating tumor progression immediately after therapy. Using the MMTV/PyVmT transgenic model of metastatic breast cancer, we show here that administration of ionizing radiation or doxorubicin caused increased circulating levels of TGF-β1 as well as increased circulating tumor cells and lung metastases. These effects were abrogated by administration of a neutralizing pan–TGF-β antibody. Radiation did not increase lung metastases in mice bearing tumors that lack the type II TGF-β receptor (TβRII). These data implicate TGF-β induced by anticancer therapy as a prometastatic signal in tumors and thus provide a rationale for the simultaneous use of these therapies in combination with TGF-β inhibitors.

Go to:
Results
Thoracic radiation and chemotherapy increase circulating TGF-β1.

We administered 10 Gy to the thoraxes or pelvises of 8-week-old FVB virgin female mice. Blood was collected 24 hours after irradiation. We observed an approximate 2-fold increase in plasma TGF-β1 in irradiated mice over controls regardless of the site of radiation (thorax, P = 0.03; pelvis, P = 0.02; Figure Figure1A),1A), while TGF-β2 levels did not change (data not shown). Similar results were obtained in 8-week-old MMTV/PyVmT transgenic mice and in nontransgenic mice transplanted with MMTV/PyVmT tumor cells stably transfected with a luciferase expression vector (P = 0.015 and P = 0.007, respectively, versus controls; Figure Figure1B).1B). Levels of TGF-β1 remained higher than controls 7 days after radiation (data not shown). To expand these results to other anticancer therapies, we examined the effect of the DNA-intercalating agent and topoisomerase II inhibitor doxorubicin (Adriamycin). Transgenic mice were treated 3 times with doxorubicin (5 mg/kg i.p.) at 21-day intervals starting at week 8. In plasma collected on week 15, TGF-β1 was also elevated 2-fold compared with untreated mice (P = 0.009; Figure Figure1C),1C), whereas TGF-β2 levels remained constant. To measure activated TGF-β1 in the lung tissue harvested 5 weeks after radiation, we used a TGF-β1 bioassay that uses mink lung epithelial cells stably expressing a plasminogen activator inhibitor–1/luciferase reporter (PAI-1/luciferase reporter) (29). Tissue lysates from irradiated mouse lungs induced a 2-fold increase in active TGF-β1 compared with nonirradiated lung tissue lysates (P = 0.0008; Figure Figure1D). 1D).

今回ご紹介するスイーツは、水色とピンクのクリームがカラフル！
そして、さくらんぼをのせてかわいく仕上げました♪
チョコチップマフィンの中にマーマレードジャムが入っていて、柑橘系の香りが口いっぱいに広がってとっても美味しいですよ♡
映えること間違いなし！ぜひ作ってみてくださいね。

さくらんぼのチョコチップマフィン
6個分

材料：
■チョコチップマフィン
無塩バター　80g
砂糖　70g
溶き卵　2個分
牛乳　50ml
マーマレードジャム　80g
A薄力粉　120g
Aココアパウダー　30g
Aベーキングパウダー　大さじ1/2
チョコチップ　60g

■カラフルクリーム
生クリーム　200ml
砂糖　大さじ1
かき氷シロップ（青・赤）各大さじ2

アラザン　適量
さくらんぼ　6個

作り方：
1.オーブンを170℃に温める。マフィン型に紙カップを敷く。

2.室温で柔らかくしたバター、砂糖をボウルに入れ、泡立て器で白っぽくなるまで混ぜる。溶いた卵を少しずつ加えてよく混ぜる。牛乳、マーマレードジャムも加えて混ぜる。

3.粉ふるいにAを合わせて混ぜ、(2)に一気に振るい入れる。ゴムベラで切るようにサックリと混ぜる。まだ粉っぽさが残っているうちにチョコチップを加えて混ぜる。

4.(3)を(1)の型に7分目くらいまで等分に入れ、オーブンで20分焼く。竹串を刺して生地がついてこなければ型から取り出して冷ます。

5.カラフルクリームを作る。別のボウルに生クリームを入れて泡立て器で5分立てまで泡立て砂糖を加えてさらに泡立てる。1/3の量を取り出しかき氷シロップの赤、残りに青のかき氷シロップを加えて混ぜる。

6.絞り袋に(5)のクリームを入れて(4)のカップケーキに絞り、アラザンをちらし、さくらんぼをのせて完成！

===

Chocolate Cherry Cupcakes
Servings: 6

INGREDIENTS
◆Chocolate cupcakes
80g unsalted butter (at room temperature)
70g sugar
2 beaten eggs
50ml milk
80g marmalade
A
120g flour
30g cocoa powder
1/2 tablespoon baking powder

60g chocolate chips

◆Colorful cream
200ml heavy cream
1 tablespoon sugar
2 tablespoons syrup (2 tablespoons each for red and blue syrup)

Some silver dragees
6 cherries

PREPARATION
1. Preheat the oven to 170°C (338°F). Line a cupcake pan with cupcake liners.

2. Whisk butter and sugar in a bowl until smooth. Add beaten eggs (little by little) and mix well. Add milk and marmalade, mix well.

3. Put all ingredients A in a sifter. Sift into the bowl (2). Fold the batter with a rubber spatula. Add chocolate chips.

4. Spoon the batter into the cupcake liners. Fill each liner about 2/3 full. Bake in the oven for 20 minutes. Insert a toothpick into the middle of the cupcake. When it comes out clean, remove cupcakes from the pan. Let them cool.

5. For colorful cream: Whip heavy cream in a bowl to medium peaks. Add sugar and whip to stiff peaks. Divide the whipped cream into 3 separate bowls. Add red syrup into one bowl, blue to another. Keep the other white.

6. Put all 3 different colored cream (5) into a piping bag. Squeeze the cream onto the cupcakes. Sprinkle some silver dragées. Tom them with a cherry.

7. Enjoy!

#TastyJapan

#レシピ

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鶏むね肉のレシピのご紹介です！
今回はおもてなしなどに最適なレシピを4種類ご用意しました♪
包んで焼くだけなのでとっても簡単♡
お好きな味でぜひ作ってみてくださいね！

おもてなし鶏むね肉料理4選
各2人分

〔ガーリックチーズチキン〕
材料：
鶏むね肉　300g
にんにく（みじん切り）　1片
パルメザンチーズ　大さじ1
ピザ用チーズ　30g
じゃがいも　40g
ドライパセリ　適量
塩　少々
粗びき黒コショウ　少々
オリーブオイル　大さじ1

作り方：
1.オーブンを200℃に予熱しておく。
2.天板に、半分に折り目を付けたクッキングシートを敷く。鶏むね肉にフォークで数カ所穴をあける。
3.クッキングシートの折り目の上部に、スライス切りにしたじゃがいもをのせ、塩、粗びき黒コショウをふる。
4.じゃがいもの上に鶏むね肉、にんにく、パルメザンチーズ、ピザ用チーズをのせ、塩、粗挽き黒コショウをしっかりめにふり、オリーブオイルをまわしかける。
5.クッキングシートを上に折り、端から扇型になるように折りたたんでいく。
6.200℃のオーブンで20〜30分焼いたら、完成！

〔照り焼きチキン〕
材料：
鶏むね肉 300g
Aしょうゆ 大さじ4
Aみりん 大さじ3
A酒 大さじ3
玉ねぎ（スライス切り） 40g
片栗粉 小さじ1
白ねぎ(白髪ねぎ切り) 10g
糸唐辛子 適量

作り方：
1.オーブンを200℃に予熱しておく。
2.天板に、半分に折り目を付けたクッキングシートを敷く。鶏むね肉はフォークで数カ所穴をあけ、片栗粉をまぶす。
3.保存袋にA、鶏むね肉を入れ、冷蔵庫に入れて漬け込む。
4.クッキングシートの折り目の上部に、玉ねぎ、漬け込んだ鶏むね肉をのせる。
5.クッキングシートを上に折り、端から扇型になるように折りたたんでいく。
6.200℃のオーブンで20〜30分焼く。
7.白ねぎ、糸唐辛子をのせたら、完成！

〔メキシカンスパイシーチキン〕
材料：
鶏むね肉 300g
Aチリパウダー 大さじ1
Aガーリックパウダー 小さじ1/2
Aクミンパウダー 小さじ½
塩 少々
粗挽き黒コショウ 少々
赤パプリカ（細切り） 20g
黄パプリカ （細切り）20g
オリーブオイル 大さじ1
パクチー 適量

作り方：
1.オーブンを200℃に予熱しておく。
2.天板に、半分に折り目を付けたクッキングシートを敷く。鶏むね肉にフォークで数カ所穴をあけ、Aを全体にまぶす。
3.クッキングシートの折り目の上部に、赤パプリカ、黄パプリカをのせ、塩、粗びき黒コショウをふる。
4.パプリカの上に鶏むね肉、塩、粗挽き黒コショウをしっかりとふり、オリーブオイルをまわしかける。
5.クッキングシートを上に折り、端から扇型になるように折りたたんでいく。
6.200℃のオーブンで20〜30分焼き、パクチーをのせたら、完成！

〔韓国風チキン〕
材料：
鶏むね肉 300g
Aコチュジャン 大さじ2
Aしょうゆ 大さじ1
A酒 大さじ1
A砂糖 大さじ1
A白すりごま 小さじ1
Aごま油 大さじ2
玉ねぎ（スライス切り） 40g
青ねぎ（小口切り） 適量
白いりごま 適量

作り方：
1.オーブンを200℃に予熱しておく。
2.天板に、半分に折り目を付けたクッキングシートを敷く。鶏むね肉にフォークで数カ所穴をあける。
3.保存袋にA、鶏むね肉を入れ、冷蔵庫に入れて漬け込む。
4.クッキングシートの折り目の上部に、玉ねぎ、漬け込んだ鶏むね肉をのせる。
5.クッキングシートを上に折り、端から扇型になるように折りたたんでいく。
6.200℃のオーブンで20〜30分焼く。
7.白いりごま、青ねぎをちらしたら、完成！


Parchment Paper! Easy Chicken Dishes 4 ways
Servings: 2

Garlic Cheese Chicken

INGREDIENTS
300g Chicken breast
1 clove Garlic (chopped)
1 tablespoon Parmesan cheese
30g Pizza cheese
40g Potato
Dried parsley
Salt
Pepper
1 tablespoon Olive oil


PREPARATION
1. Preheat the oven to 200 ° C.
2. Fold a parchment paper sheet in half, open and place flat on a cooking sheet. Make a few holes in the chicken breast with a fork.
3. Sliced the potato and place the slices on top of the parchment paper, sprinkle with salt and coarsely ground black pepper.
4. Place chicken breast, garlic, parmesan cheese, and pizza cheese on top of the potatoes, sprinkle with salt, pepper, and olive oil.
5. Fold the parchment paper to fully cover the chicken breast and fold the sides to make a fan shape.
6. Bake in the oven at 200 ° C for 20-30 minutes and you're done!
7. Enjoy!


Teriyaki Chicken

INGREDIENTS
300g Chicken breast
A 4 tablespoons Soy sauce
A 3 tablespoons Mirin
A 3 tablespoons Sake
40g Onion (sliced)
1 teaspoon Potato starch
10g Spring onion
Ito togarashi (to top)

PREPARATION
1. Preheat the oven to 200 ° C.
2. Fold a parchment paper sheet in half, open and place flat on a cooking sheet. Make a few holes in the chicken breast with a fork and sprinkle with potato starch.
3. Put A ingredients and chicken breast in a ziplock bag, put it in the refrigerator to marinate.
4. Place onions and marinated chicken breast on the parchment paper.
5. Fold the parchment paper to cover everything and fold the edges to form a fan.
6. Bake in the oven at 200 ° C for 20-30 minutes.
7. Top with spring onion and the ito togarashi, and you're done!
8. Enjoy!

Mexican Spicy Chicken

INGREDIENTS
300g Chicken breast
A 1 tablespoon Chili powder
A 1/2 teaspoon Garlic powder
A 1/2 teaspoon Cumin powder
Salt
Pepper
20g Red paprika (sliced)
20g Yellow paprika (sliced)
1 tablespoon Olive oil
Coriander

PREPARATION
1. Preheat the oven to 200 ° C.
2. Fold a parchment paper sheet in half, open and place flat on a cooking sheet. Make a few holes in the chicken breast with a fork and coat with all the A spices.
3. Place red and yellow paprika on top of the parchment paper and sprinkle with salt and coarse black pepper.
4. Place the chicken breast, on top of the paprika, and season with salt and coarsely ground black pepper, top with olive oil.
5. Fold the parchment paper to cover everything and fold the edges to form a fan.
6. Bake in an oven at 200 ° C for 20 to 30 minutes, finish by topping with coriander and you're done!
7. Enjoy!

Korean Chicken

INGREDIENTS
300g Chicken breast
A 2 tbsp Gochujang
A 1 tablespoon Soy sauce
A 1 tablespoon Sake
A 1 tablespoon Sugar
A 1 teaspoon White sesame seeds
A 2 tablespoons Sesame oil
40g Onion (sliced)
Green onion (cut into small pieces)
White sesame seeds (to top)

PREPARATION
1. Preheat the oven to 200 ° C.
2. Fold a parchment paper sheet in half, open and place flat on a cooking sheet. Make a few holes in the chicken breast with a fork.
3. Place A ingredients and chicken breast in a ziplock bag, place in the refrigerator to marinate.
4. Place onions and marinated chicken breast on top of the parchment paper.
5. Fold the parchment paper to cover everything and fold the edges to form a fan.
6. Bake in the oven at 200 ° C for 20-30 minutes.
7. Top with white sesame seeds and green onions, and you're done!
8. Enjoy!

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